Browse our CTNNB1 Proteins (CTNNB1)

Horse (Equine) Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. significantly increased gene expression in early osteochondrosis osteochondral junction chondrocytes compared to controls

2. temporal expression of CTNNB1 mRNA during dermal wound repair in the horse

Mouse (Murine) Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. O-GlcNAcylation of CTNNB1 is associated with tumorigenicity of colorectal cancer.

2. this study identified activation of beta-catenin-mediated signaling in cardiac macrophages post-myocardial infarction

3. This study reports that the gain-of-function mutation of full-length basally-expressing Htt in Huntington's disease cell Q111 (STHdhQ111/HdhQ111) upregulated microRNA-214 and decreased beta catenin & its transcriptional activity in an aggregate-independent manner.

4. beta-catenin plays an essential role in differentiation and function of ameloblasts during amelogenesis

5. Janus kinase 2 protein (JAK2) and beta-catenin were found to interact with cadherin-22 (Cdh22) and involved in CDH22 signaling in female germ line stem cells (FGSCs).

6. In fibrocystin/polyductin complex-defective cholangiocytes, beta-catenin and IL-1beta are responsible for signal transducer and activator of transcription 3-dependent secretion of CXCL10

7. Data illustrates a cooperative effect of the direct oncogenic signaling of mutant beta-catenin and MET in hepatocytes with hepatic tumor-promoting stroma induced by beta-catenin deficiency

8. Data show that beta-catenin can physically interact with Polycomb Repressive Complex 2 (PRC2) components in the cranial mesenchyme (CM).

9. Study identified FXR/beta-catenin interaction whose modulation through beta-catenin suppression promotes FXR activation and decreases hepatic bile acids, which may provide unique therapeutic opportunities in cholestatic liver diseases

10. In this study, we found that the wnt co-receptor Lrp6 was a potent positive regulator of beta-catenin signaling in TDI-induced asthma models, both in vivo and in vitro. Additionally, for the first time, we demonstrated that RAGE could mediate phosphorylation of Lrp6, suggesting a functional cross talk between RAGE and the canonical wnt/beta-catenin signaling pathway involved in mediating beta-catenin activation.

11. These data indicate that SMAD3- and beta-catenin-dependent induction occurs in the taurine transporter knockout mouse

12. beta-catenin in osterix-expressing cells is required for postnatal osteoblast differentiation, osteoblast proliferation, and bone resorption, and is essential for the anabolic actions of parathyroid hormone in bone.

13. Adherens as well as tight junction marker proteins were rapidly and consistently upregulated in both the germinal as well as the functional layer of the oral mucosa. This represents a previously unknown parameter of the epithelial radiation response to clinically relevant fractionation protocols. CONCLUSION: Fractionated irradiation significantly enhanced the expression of all proteins investigated. This study revealed a

14. the beta-catenin C-terminus indirectly represses p53, and this function is essential for embryogenesis.

15. aberrant expression of AF1q may activate Wnt/beta-catenin signaling and result in podocyte injury.

16. this study suggested that stabilized beta-catenin ameliorated some Autoimmune lymphoproliferative syndrome-like symptoms of lpr/lpr mice by potentiating Fas-independent signal-mediated T cell apoptosis

17. findings indicate that beta-catenin signaling plays a critical role in postnatal bone remodeling. Our study provides new insights into the regulation of epiphyseal bone homeostasis at postnatal stage

18. Study validates the DNAJB1-PRKACA fusion kinase as an oncogenic driver and candidate drug target for fibrolamellar hepatocellular carcinoma in mouse model in which tumorigenesis was significantly enhanced by genetic activation of beta-catenin.

19. BCAS2 is an upstream regulator of beta-catenin gene expression and plays a role in dendrite growth at least partly through beta-catenin in the forebrain.

20. LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose-induced podocyte injury via its interplay with beta-catenin and SRSF1.

Zebrafish Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. Studied apoptosis and the Wnt/beta-catenin pathway in the cases of bisphenol A (BPA) and di(2-ethylhexyl) phthalate (DEHP) exposure in zebrafish embryos.

2. Wnt/beta-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling in the process of neovascularization of the central nervous system and blood-brain barrier formation.

3. The results demonstrate that the argon plasma jet has no adverse effects on fin regeneration and embryogenesis in zebrafish, and does not interrupt the (Wnt)/beta-Catenin-signaling pathways.

4. The expression of c-kit and beta-catenin suggests that erythropoietin may exert a role in regeneration reducing the extent of tubular damage from the outset after gentamicin administration.

5. Net1-regulated beta-catenin activation plays a crucial role in the dorsal axis formation during zebrafish development.

6. Wnt/beta-catenin signaling induces expression of col12a1a/b and deposition of Collagen XII, which is necessary for axons to actively navigate the non-neural lesion site environment.

7. Mechanistically, Hif-3alpha2 binds to beta-catenin and destabilizes the nuclear beta-catenin complex.

8. Nuclear beta-catenin is an indication of an activated Wnt pathway, therefore suggesting a possible role for Wnt signalling during zebrafish tooth development and replacement.

9. Findings suggest that microRNA 19b (miR-19b) regulates laterality development and heart looping in embryos by targeting beta-catenin ctnnb1.

10. Custos binds to beta-catenin in a Wnt responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.

11. The role of the beta-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila.

12. The Wnt/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality. (Review)

13. This study demonstrated that beta-catenin/Wnt signaling is initially required to activate cell-cycle re-entry in Muller glia following injury and that Wnt signaling subsequently controls the fate of the progeny of those cell divisions.

14. A novel role for Eaf1 and Eaf2 in inhibiting canonical Wnt/beta-catenin signaling, which might form the mechanistic basis for Eaf1 and Eaf2 tumor suppressor activity.

15. Ccr7 functions during axis formation as a GPCR to inhibit beta-catenin, likely by promoting Ca(2+) transients throughout the blastula.

16. ctnnb1 and ctnnb2 regulate multiple processes of laterality development in zebrafish embryos through similar and distinct mechanisms.

17. 2-OST functions within the Wnt pathway, downstream of Wnt ligand signaling and upstream of Gsk3beta and beta-catenin intracellular localization and function

18. It was shown that Wnt3a-Wnt8a/beta-catenin signaling directly regulates ciliogenic transcription factor foxj1a expression and ciliogenesis in zebrafish Kupffer's vesicle.

19. A Disc1 peptide binds to GSK3beta, and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin-mediated Wnt signaling and inhibiting GSK3beta activity.

20. Foxo3b played a very important role in embryogenesis and negatively regulated maternal and zygotic Wnt/beta-catenin signaling by directly interacting with both beta-catenin1 and beta-catenin2.

Xenopus laevis Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. We identified the amphibian leap2 gene which is highly related to its mammalian orthologues at both structural and sequence levels. The gene is expressed in the embryo mostly in the endoderm-derived tissues. Accordingly it is induced in pluripotent animal cap cells by FGF, activin or a combination of vegT/beta-catenin.

2. Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A and thereby down-regulating the Wnt/beta-catenin signaling.

3. maternal Wnt/STOP signaling, but not beta-catenin signaling, has a role in cleavage after fertilization and cell cycle progression

4. Custos binds to beta-catenin in a Wnt responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.

5. Wnt signalling can benefit from nucleo-cytoplasmic shuttling of APC, Axin and GSK3, although they are in general beta-catenin antagonising proteins.

6. Phosphoinositide 3-kinase and Rac polarization depend specifically on the N-cadherin-p120 catenin complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin-beta-catenin complex.

7. HERG channel activity is stimulated by beta-catenin

8. Zic3 can suppress Wnt/beta-catenin signaling and control development of the notochord and Spemann's organizer.

9. Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3

10. The tyrosine kinase receptor, PTK7, is implicated in beta-catenin-dependent developmental processes.

11. Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity.

12. Activated Xenopus CTNNB1 regulates embryonic limb development via FGF signaling

13. data demonstrate a positive role for protein phosphatase 2A:B56epsilon in the Wnt/beta-catenin signaling pathway

14. Data support a mechanism in which maternal XSOX3 inhibits beta-catenin-mediated axis specification by repressing expression of Xnr5.

15. Chordin, Noggin, beta-Catenin, and Cerberus have roles in neural induction in Xenopus

16. Sox17 and beta-catenin interact to transcribe endodermal target genes

17. The localized activation of Wnt/beta-catenin signaling, which converts Tcf from a repressor to an activator, is required for the establishment of dorsal-ventral patterning in the prospective diencephalon.

18. Expression of Btg-x protein is regulated by both beta-Catenin and Nodal-related signals.

19. High activity of beta catenin led to efficient cell sorting from the notochord to the somites, whereas reduced activity led to sorting in the opposite direction.

20. Tcf/Lef genes encode factors of different activities, which function together in antagonistic or synergistic ways to modulate the intensity and outcome of Wnt/beta-catenin signalling and to trigger tissue-specific responses.

Human Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. CXC chemokine ligand 9 promotes the progression of diffuse large B-cell lymphoma in a beta-catenin-dependent manner.

2. Results suggest that epigenetic regulation of CTNNB1 may serve as a novel avenue to block colon cancer cell migration and invasion.

3. The results demonstrated that 2HF could inhibit EMT, and cell migration and invasion through the Wnt/bcatenin signaling pathway by suppressing GSK3b phosphorylation, betacatenin expression and transactivation.

4. Collectively, these studies suggested the cellular transcription factor beta-catenin stimulates productive herpes simplex virus 1infection, in part because VP16 enhances beta-catenin dependent transcription.

5. CTNNB1 mutations may be more related to tumorigenesis ( aldosterone-producing adenoma) rather than excessive aldosterone production

6. CTNNB1 mutations were found in 60% of Basal cell adenoma but not in basal cell adenocarcinoma. None of the tested cases had PIK3CA mutations. CTNNB1 mutation trended to be more common in those cases having a predominant tubular or tubulotrabecular patterns.

7. Data reveal that post-translational modifications of beta-catenin in the ubiquitin-proteasome pathway yield a truncated beta-catenin molecule containing a serine 552-phosphorylated core region without N and C termini. This proteolytic processing of beta-catenin is required for binding with TCF4 and subsequent transcriptional activation.

8. Results identify CTNNB1 as a Girdin-interacting protein. Girdin-depleted skin cancer cells displayed scattering and impaired E-cadherin-specific cell-cell adhesion.

9. the dysregulation of TET2/E-cadherin/beta-catenin regulatory loop is a critical oncogenic event in HCC progression

10. High CTNNB1 expression is associated with bladder cancer progression.

11. It has been found that miR-27a-3p modulated the Wnt/beta-catenin signaling pathway to promote epithelial-mesenchymal transition in oral squamous carcinoma stem cells by down-regulating SFRP1.

12. Beta-catenin pathway is activated by CBX8 in in hepatocellular carcinoma.

13. our data provide a novel evidence for the biological and clinical significance of SPAG5 as a potential biomarker, and we demonstrate that SPAG5-b-catenin-SCARA5 might be a novel pathway involved in hepatocellular carcinoma progression.

14. Results show that hypoxia enhanced nuclear accumulation and transcriptional activity of beta-catenin which promotes expression of EMT-related genes and eventually contributes to the metastatic process in lung cancer cells.

15. This study demonstrates that FOXC1 induces cancer stem cells (CSCs)-like properties in non-small cell lung cancer (NSCLC) by promoting beta-catenin expression. The findings indicate that FOXC1 is a potential molecular target for anti-CSC-based therapies in NSCLC

16. High TBL1XR1 expression indicates poor disease-free survival of stage I-III colorectal cancer patients; beta-catenin signaling is critical for TBL1XR1-mediated colorectal cancer cells oncogenicity.

17. Taking together, these results suggest that Wnt/beta-catenin signal pathway activation-dependent up-regulation of syncytin-1 contributes to the pro-inflammatory factor TNF-alpha-enhanced fusion between oral squamous cell carcinoma cells and endothelial cells.

18. The disassociation of the beta-catenin/E-cadherin complex in the osteoblast membrane under stretch loading and the subsequent translocation of beta-catenin into the nucleus may be an intrinsic mechanical signal transduction mechanism.

19. Aberrant CTNNB1 expression was seen in a substantial proportion of our hepatocellular carcinoma (HCC) cases. CTNNB1-positive HCC was associated with normal AFP levels, unicentric tumors, well-differentiated histology, and an unfavorable outcome.

20. Long noncoding RNA AFAP1-AS1 enhances cell proliferation and invasion in osteosarcoma through regulating miR-4695-5p/TCF4-beta-catenin signaling.

Pig (Porcine) Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. Results highlight a potential role for the beta-catenin/Wnt and Notch signalling pathways during the infection of crypt cells by L. intracellularis.

2. Flutamide exposure led to decreased beta-catenin in corpus luteum of mid/late pregnancy.

3. beta-catenin signaling is involved in formation of contractile membranes by dedifferentiated retinal pigment epithelium cells.

4. Wnt3a produced a significant increase in heart valve interstitial cell number at day 4 and in the percentage of BrdU-positive nuclei at 24 h. The increase in proliferation was abolished by beta-catenin siRNA.

5. This study tested whether prenatal and neonatal exposure to antiandrogen flutamide affected ovarian 17beta-estradiol synthesis and the associated gene expression in large antral follicles of adult pigs.

6. beta-catenin controls myocardin-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes

7. beta-Catenin plays a critical role in mediating TGF-beta1-induced myofibroblast differentiation in aortic valve interstitial cells.

8. scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of Glycogen synthase kinase 3beta activity which can lead to activation of the downstream signaling through beta-catenin

9. Data show that Wnt3a can inhibit the adipogenic differentiation of porcine AMSCs, and suggest that Wnt/beta-catenin signaling inhibits adipogenic differentiation potential and alters the cell fate from adipocytes to osteoblasts.

10. TNF-alpha inhibits adipogenesis through stabilization of beta-catenin protein in porcine preadipocytes.

Cow (Bovine) Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. Bovine herpesvirus 1 transiently increased beta-catenin protein levels in bovine kidney cells, but not in rabbit skin cells.

2. These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.

3. beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves.

4. These data demonstrate for the first time that FSH regulates CTNNB1 protein and WNT2 mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT signaling in ovarian steroidogenesis and follicular growth of cattle.

5. These data provide evidence that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin-targeted genes and myogenesis in the muscle-derived stem cells of cattle.

6. that beta-catenin is a plasma membrane-associated protein in airway smooth muscle that regulates active tension development, presumably by stabilizing cell-cell contacts and thereby supporting force transmission between neighboring cells.

7. This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin.

8. TGF-beta3 induces the chondrogenic differentiation of pericytes by inducing Wnt/beta-catenin signaling and T-cell factor-induced gene transcription.

9. cAMP/PKA regulation of GSK3beta/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.

Rabbit Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. Palmatin effect on osteoarthritis is likely mediated via the Wnt/beta-catenin and Hedgehog signaling

2. These results collectively showed that 2-Deoxy-D-glucose regulates dedifferentiation via beta-catenin pathway in rabbit articular chondrocytes.