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Human CTNNB1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004177
Hülsken, Birchmeier, Behrens: E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. in The Journal of cell biology 1995
Show all 6 Pubmed References
Human CTNNB1 Protein expressed in Wheat germ - ABIN1350670
Bian, Bai, Chapin, Le Moellic, Dong, Caplan, Sigworth, Navaratnam: Interactions between ?-catenin and the HSlo potassium channel regulates HSlo surface expression. in PLoS ONE 2011
temporal expression of CTNNB1 mRNA during dermal wound repair in the horse
These data suggested that Wnt (show WNT2 Proteins)/beta-catenin pathway might be a potential target to treat the LPS (show TLR4 Proteins)-induced inflammation in ALI.
Data show that Wnt (show WNT2 Proteins) beta-Catenin signaling pathway activation followed by Notch (show NOTCH1 Proteins) inhibition strongly promotes the mitotic regeneration of new hair cell (HC) in both normal and neomycin-damaged cochleae.
KY1022, a small molecule that destabilizes both beta-catenin and Ras by targeting the Wnt (show WNT2 Proteins)/beta-catenin pathway, inhibitits cellular events, including epithelial mesenchymal transformation, an initial process of metastasis, and apoptosis in colorectal cancer cells.
Cardiomyocyte hypertrophy is blunted with cardiac fibroblast-specific loss of beta-catenin after trans-aortic constriction in vivo.
These results collectively suggest that sustained activation of Wnt (show WNT2 Proteins)/beta-catenin signaling in endothelial cells might be a cause of heart failure through suppressing neuregulin-ErbB (show EGFR Proteins) signaling.
Our findings indicate that H2O2 inhibits NaV1.5 (show SCN5A Proteins) expression by activating the Wnt/b-catenin signaling and beta-catenin interacts with TCF4 (show TCF4 Proteins) to transcriptionally suppress cardiac NaV1.5 (show SCN5A Proteins) expression.
TGF-beta (show TGFB1 Proteins) and beta-catenin crosstalk in proximal tubules may have a role in tubular injury in two models of chronic kidney disease
Results indicate that ablation of epithelial Wnt (show WNT2 Proteins)/beta-catenin signaling affected epididymal epithelial cell proliferation but did not inhibit cell differentiation.
Interactions between the Wnt (show WNT2 Proteins)/beta-catenin and the Kras/ERK (show EPHB2 Proteins)/Foxm1 (show FOXM1 Proteins) pathways are essential to restrict SOX9 (show SOX9 Proteins) expression in basal cells during pulmonary branching morphogenesis
The collective results indicate that the osteoanabolic response to loading can occur on the periosteal surface when beta-cat levels are significantly reduced in Dmp1 (show DMP1 Proteins)-expressing cells.
Net1-regulated beta-catenin activation plays a crucial role in the dorsal axis formation during zebrafish development.
Wnt (show WNT2 Proteins)/beta-catenin signaling induces expression of col12a1a/b and deposition of Collagen XII, which is necessary for axons to actively navigate the non-neural lesion site environment.
Mechanistically, Hif-3alpha2 binds to beta-catenin and destabilizes the nuclear beta-catenin complex.
Nuclear beta-catenin is an indication of an activated Wnt (show WNT2 Proteins) pathway, therefore suggesting a possible role for Wnt (show WNT2 Proteins) signalling during zebrafish tooth development and replacement.
Findings suggest that microRNA 19b (miR (show MYLIP Proteins)-19b) regulates laterality development and heart looping in embryos by targeting beta-catenin ctnnb1.
Custos binds to beta-catenin in a Wnt (show WNT2 Proteins) responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.
The role of the beta-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila.
The Wnt (show WNT2 Proteins)/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality. (Review)
This study demonstrated that beta-catenin/Wnt (show WNT2 Proteins) signaling is initially required to activate cell-cycle re-entry in Muller glia following injury and that Wnt (show WNT2 Proteins) signaling subsequently controls the fate of the progeny of those cell divisions.
A novel role for Eaf1 (show EAF1 Proteins) and Eaf2 (show EAF2 Proteins) in inhibiting canonical Wnt (show WNT2 Proteins)/beta-catenin signaling, which might form the mechanistic basis for Eaf1 (show EAF1 Proteins) and Eaf2 (show EAF2 Proteins) tumor suppressor activity.
We identified the amphibian leap2 (show LEAP2 Proteins) gene which is highly related to its mammalian orthologues at both structural and sequence levels. The gene is expressed in the embryo mostly in the endoderm-derived tissues. Accordingly it is induced in pluripotent animal cap cells by FGF, activin or a combination of vegT/beta-catenin.
Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A (show PPP2R2B Proteins) and thereby down-regulating the Wnt (show WNT2 Proteins)/beta-catenin signaling.
maternal Wnt (show WNT2 Proteins)/STOP signaling, but not beta-catenin signaling, has a role in cleavage after fertilization and cell cycle progression
Wnt (show WNT2 Proteins) signalling can benefit from nucleo-cytoplasmic shuttling of APC (show APC Proteins), Axin (show AXIN1 Proteins) and GSK3, although they are in general beta-catenin antagonising proteins.
Phosphoinositide 3-kinase and Rac (show AKT1 Proteins) polarization depend specifically on the N-cadherin (show CDH2 Proteins)-p120 catenin (show CTNND1 Proteins) complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin (show CDH2 Proteins)-beta-catenin complex.
HERG (show KCNH2 Proteins) channel activity is stimulated by beta-catenin
Zic3 (show ZIC3 Proteins) can suppress Wnt (show WNT2 Proteins)/beta-catenin signaling and control development of the notochord and Spemann's organizer.
Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3
The tyrosine kinase receptor (show KDR Proteins), PTK7 (show PTK7 Proteins), is implicated in beta-catenin-dependent developmental processes.
In conclusion, oxLDL induced MALAT1 transcription and MALAT1 recruits beta-catenin to binding sites on the CD36 (show CD36 Proteins) promoter to induce CD36 (show CD36 Proteins) expression, which enhances lipid uptake in macrophages.
Results provide evidence that stabilization and activation of beta-catenin may be a mechanism which underlies the efficacy of GSK- 3beta inhibition in osteosarcoma.
stage-specific regulation of the WNT (show WNT2 Proteins)/beta-catenin pathway results in improved differentiation of human embryonic stem cells (hESCs) to functional hepatocytes.
Study show that phospho-beta-catenin in centrosomes was reduced by FILIP1L following WNT (show WNT2 Proteins) signaling activation. The degradation of beta-catenin by FILIP1L promotes EMT (show ITK Proteins) suppression, thereby inhibiting metastases and chemoresistance of ovarian tumors.
the loss of c-Cbl (show CBL Proteins) activity significantly enhanced nuclear beta-catenin and colorectal cancer tumor growth in cell culture and a mouse xenograft model.
beta-catenin was predominantly associated with Na+/H+ exchanger regulating factor 1 (NHERF1 (show SLC9A3R1 Proteins)) in a dynamic context and an increase of its oncogenic function through RAS-association domain family 1 (show RASSF1 Proteins), isoform A (RASSF1A (show RASSF1 Proteins)) inactivation in liver metastases.
Data indicate cross-talks between MYCN (show MYCN Proteins) and beta-catenin signalling, which repress normal beta-catenin mediated transcriptional regulation.
mutations in TERT (show TERT Proteins) promoter and in CTNNB1 gene represent specific cancer signatures in the pathogenesis of viral related HCC (show FAM126A Proteins).
Multiple myeloma that is driven by deregulated iron homeostasis and/or Pyk2 (show PTK2B Proteins)/beta-cateninn signaling is susceptible to deferasirox-induced apoptosis.
Results highlight a potential role for the beta-catenin/Wnt (show WNT2 Proteins) and Notch (show NOTCH1 Proteins) signalling pathways during the infection of crypt cells by L. intracellularis.
Flutamide exposure led to decreased beta-catenin in corpus luteum of mid/late pregnancy.
beta-catenin signaling is involved in formation of contractile membranes by dedifferentiated retinal pigment epithelium cells.
Wnt3a (show WNT3A Proteins) produced a significant increase in heart valve interstitial cell number at day 4 and in the percentage of BrdU-positive nuclei at 24 h. The increase in proliferation was abolished by beta-catenin siRNA.
beta-catenin controls myocardin-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes
beta-Catenin plays a critical role in mediating TGF-beta1 (show TGFB1 Proteins)-induced myofibroblast differentiation in aortic valve interstitial cells.
scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of Glycogen synthase kinase 3beta activity which can lead to activation of the downstream signaling through beta-catenin
Data show that Wnt3a (show WNT3A Proteins) can inhibit the adipogenic differentiation of porcine AMSCs, and suggest that Wnt (show WNT2 Proteins)/beta-catenin signaling inhibits adipogenic differentiation potential and alters the cell fate from adipocytes to osteoblasts.
TNF-alpha (show TNF Proteins) inhibits adipogenesis through stabilization of beta-catenin protein in porcine preadipocytes.
Bovine herpesvirus 1 transiently increased beta-catenin protein levels in bovine kidney cells, but not in rabbit skin cells.
These results demonstrate that activation of AKT (show AKT1 Proteins) is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.
beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves.
These data demonstrate for the first time that FSH (show BRD2 Proteins) regulates CTNNB1 protein and WNT2 (show WNT2 Proteins) mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT (show WNT2 Proteins) signaling in ovarian steroidogenesis and follicular growth of cattle.
These data provide evidence that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin-targeted genes and myogenesis in the muscle-derived stem cells of cattle.
that beta-catenin is a plasma membrane-associated protein (show PDZK1IP1 Proteins) in airway smooth muscle that regulates active tension development, presumably by stabilizing cell-cell contacts and thereby supporting force transmission between neighboring cells.
This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin.
TGF-beta3 (show TGFB3 Proteins) induces the chondrogenic differentiation of pericytes by inducing Wnt (show WNT2 Proteins)/beta-catenin signaling and T-cell factor-induced gene transcription.
cAMP/PKA regulation of GSK3beta/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.
Palmatin effect on osteoarthritis is likely mediated via the Wnt (show WNT2 Proteins)/beta-catenin and Hedgehog (show SHH Proteins) signaling
These results collectively showed that 2-Deoxy-D-glucose regulates dedifferentiation via beta-catenin pathway in rabbit articular chondrocytes.
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
catenin beta 1 subunit
, catenin beta-1
, beta catenin 1
, catenin (cadherin-associated protein), beta 1, 88kDa
, catenin beta-1-like
, catenin (cadherin associated protein), beta 1, 88kDa
, catenin beta
, beta catenin