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Human CTNNB1 Protein expressed in Wheat germ - ABIN1350670
Bian, Bai, Chapin, Le Moellic, Dong, Caplan, Sigworth, Navaratnam: Interactions between ?-catenin and the HSlo potassium channel regulates HSlo surface expression. in PLoS ONE 2011
Human CTNNB1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004177
Hülsken, Birchmeier, Behrens: E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. in The Journal of cell biology 1995
Show all 6 Pubmed References
temporal expression of CTNNB1 mRNA during dermal wound repair in the horse
Rspo3 (show RSPO3 Proteins)-LGR4 (show LGR4 Proteins) axis protects hepatocytes from hypoxia/reoxygenation injury via activating beta-catenin.
Modulation of beta-catenin levels or disruption of its cell adhesion role is correlated with aggressive tumorigenesis in basal ErbB2 (show ERBB2 Proteins)-driven mammary tumors with preexisting beta-catenin activation. Our data also emphasize the tumor suppressor role of beta-catenin, similar to other adherens junction proteins, in maintaining junctional integrity during tumor progression.
study uncovers a role for Pdpn (show PDPN Proteins) in mammary SC function and, importantly, identifies Pdpn (show PDPN Proteins) as a new regulator of Wnt (show WNT2 Proteins)/beta-catenin signaling, a key pathway in mammary development and tumorigenesis
CEACAM1 (show CEACAM1 Proteins) controls epithelial-mesenchymal transition in vitro and in vivo by site-specific regulation of beta-catenin phosphorylation
increased mesenchymal Wnt (show WNT2 Proteins) signaling inhibits the sequential formation of teeth, and suggest that Axin2 (show AXIN2 Proteins)/Runx2 (show RUNX2 Proteins) antagonistic interactions modulate the level of mesenchymal Wnt (show WNT2 Proteins)/beta-catenin signaling, underlying the contrasting dental phenotypes caused by human AXIN2 (show AXIN2 Proteins) and RUNX2 (show RUNX2 Proteins) mutations
beta-catenin (CTNNB1) maintains lung progenitors by promoting a hierarchical lung progenitor gene signature, suppressing gastrointestinal (GI) genes, and regulating NK2 homeobox 1 (NKX2.1 (show NKX2-1 Proteins)) and SRY box 2 (SOX2 (show SOX2 Proteins)) in a developmental stage-dependent manner.
findings provide the first line of evidence that links beta-catenin function to the cell proliferation and progenitor establishment during larynx and vocal fold development.
In mice that were separated from their mothers, cdh-1 is upregulated in the prefrontal cortex in both males and females. In addition, hippocampal CDH-1 mRNA levels were positively correlated with recognition memory performance in females. Maternal-separated reared male mice exhibited higher beta -Cat mRNA levels in the hippocampus.
PTEN-beta-catenin signaling is a novel regulator involved in modulating Treg development and may lead to a potential therapeutic target in liver ischemia/reperfusion injury
These results indicate that Wnt (show WNT2 Proteins)/beta-catenin signaling may play a key role in fibrotic scar formation after traumatic spinal cord injury.
The results demonstrate that the argon plasma jet (show FBXL15 Proteins) has no adverse effects on fin regeneration and embryogenesis in zebrafish, and does not interrupt the (Wnt (show WNT2 Proteins))/beta-Catenin-signaling pathways.
The expression of c-kit and beta-catenin suggests that erythropoietin (show EPO Proteins) may exert a role in regeneration reducing the extent of tubular damage from the outset after gentamicin administration.
Net1-regulated beta-catenin activation plays a crucial role in the dorsal axis formation during zebrafish development.
Wnt (show WNT2 Proteins)/beta-catenin signaling induces expression of col12a1a/b and deposition of Collagen XII, which is necessary for axons to actively navigate the non-neural lesion site environment.
Mechanistically, Hif-3alpha2 binds to beta-catenin and destabilizes the nuclear beta-catenin complex.
Nuclear beta-catenin is an indication of an activated Wnt (show WNT2 Proteins) pathway, therefore suggesting a possible role for Wnt (show WNT2 Proteins) signalling during zebrafish tooth development and replacement.
Findings suggest that microRNA 19b (miR (show MYLIP Proteins)-19b) regulates laterality development and heart looping in embryos by targeting beta-catenin ctnnb1.
Custos binds to beta-catenin in a Wnt (show WNT2 Proteins) responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.
The role of the beta-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila.
The Wnt (show WNT2 Proteins)/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality. (Review)
We identified the amphibian leap2 (show LEAP2 Proteins) gene which is highly related to its mammalian orthologues at both structural and sequence levels. The gene is expressed in the embryo mostly in the endoderm-derived tissues. Accordingly it is induced in pluripotent animal cap cells by FGF, activin or a combination of vegT/beta-catenin.
Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A (show PPP2R2B Proteins) and thereby down-regulating the Wnt (show WNT2 Proteins)/beta-catenin signaling.
maternal Wnt (show WNT2 Proteins)/STOP signaling, but not beta-catenin signaling, has a role in cleavage after fertilization and cell cycle progression
Wnt (show WNT2 Proteins) signalling can benefit from nucleo-cytoplasmic shuttling of APC (show APC Proteins), Axin (show AXIN1 Proteins) and GSK3, although they are in general beta-catenin antagonising proteins.
Phosphoinositide 3-kinase and Rac (show AKT1 Proteins) polarization depend specifically on the N-cadherin (show CDH2 Proteins)-p120 catenin (show CTNND1 Proteins) complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin (show CDH2 Proteins)-beta-catenin complex.
HERG (show KCNH2 Proteins) channel activity is stimulated by beta-catenin
Zic3 (show ZIC3 Proteins) can suppress Wnt (show WNT2 Proteins)/beta-catenin signaling and control development of the notochord and Spemann's organizer.
Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3
The tyrosine kinase receptor (show KDR Proteins), PTK7 (show PTK7 Proteins), is implicated in beta-catenin-dependent developmental processes.
When considering endometrioid tumors of all grades and stages, CTNNB1 mutant tumors were associated with significantly higher rates of grades 1-2 disease, lower rates of deep myometrial invasion, and lower rates of lymphatic/vascular space invasion.
findings demonstrated that reduced membranous E-cadherin (show CDH1 Proteins) and aberrant beta-catenin expression were frequent events in SRCCs of various organs, and that the altered beta-catenin expression was significantly associated with advanced disease
Consistent with bioinformatics predictions, SOX7 (show SOX7 Proteins) was correlated positively with AXIN2 (show AXIN2 Proteins) and negatively with beta-catenin, suggesting that SOX7 (show SOX7 Proteins) and AXIN2 (show AXIN2 Proteins) might play important roles as co-regulators through the Wnt (show WNT2 Proteins)-beta-catenin pathway in the breast tissue to affect the carcinogenesis process.
application of dexamethasone reduced the expression of RUNX2 (show RUNX2 Proteins) and beta-catenin in human gingiva-derived mesenchymal stem cells
The lower apoptotic activity of low-grade slightly elevated adenomas can be partly attributed to upregulated beta-catenin pathway activity and downregulated c-Myc (show MYC Proteins) expression.
miR (show MLXIP Proteins)-330 inhibits IL-22 (show IL22 Proteins)-induced proliferation of HaCaT and HKC cell by targeting CTNNB1.
Overexpression of vPK led to reduced mRNA expression of cyclin D1 (show CCND1 Proteins), a well-known transcriptional product of Wnt (show WNT2 Proteins) signaling, suggesting that vPK effectively regulates the host signaling pathway through direct interactions with cellular proteins.
miR (show MLXIP Proteins)-218 promoted the apoptosis of human ovarian carcinoma cells via suppression of the WNT (show WNT2 Proteins)/beta-catenin signaling pathway.
Infection with bacterial AvrA-expressing Salmonella activates the STAT3 (show STAT3 Proteins) pathway, which induces the beta-catenin signals and enhances colonic tumorigenesis. (Review)
High CTNNB1 expression is associated with epithelial-mesenchymal transition in hepatocellular carcinoma.
Results highlight a potential role for the beta-catenin/Wnt (show WNT2 Proteins) and Notch (show NOTCH1 Proteins) signalling pathways during the infection of crypt cells by L. intracellularis.
Flutamide exposure led to decreased beta-catenin in corpus luteum of mid/late pregnancy.
beta-catenin signaling is involved in formation of contractile membranes by dedifferentiated retinal pigment epithelium cells.
Wnt3a (show WNT3A Proteins) produced a significant increase in heart valve interstitial cell number at day 4 and in the percentage of BrdU-positive nuclei at 24 h. The increase in proliferation was abolished by beta-catenin siRNA.
beta-catenin controls myocardin-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes
beta-Catenin plays a critical role in mediating TGF-beta1 (show TGFB1 Proteins)-induced myofibroblast differentiation in aortic valve interstitial cells.
scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of Glycogen synthase kinase 3beta activity which can lead to activation of the downstream signaling through beta-catenin
Data show that Wnt3a (show WNT3A Proteins) can inhibit the adipogenic differentiation of porcine AMSCs, and suggest that Wnt (show WNT2 Proteins)/beta-catenin signaling inhibits adipogenic differentiation potential and alters the cell fate from adipocytes to osteoblasts.
TNF-alpha (show TNF Proteins) inhibits adipogenesis through stabilization of beta-catenin protein in porcine preadipocytes.
Bovine herpesvirus 1 transiently increased beta-catenin protein levels in bovine kidney cells, but not in rabbit skin cells.
These results demonstrate that activation of AKT (show AKT1 Proteins) is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.
beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves.
These data demonstrate for the first time that FSH (show BRD2 Proteins) regulates CTNNB1 protein and WNT2 (show WNT2 Proteins) mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT (show WNT2 Proteins) signaling in ovarian steroidogenesis and follicular growth of cattle.
These data provide evidence that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin-targeted genes and myogenesis in the muscle-derived stem cells of cattle.
that beta-catenin is a plasma membrane-associated protein (show PDZK1IP1 Proteins) in airway smooth muscle that regulates active tension development, presumably by stabilizing cell-cell contacts and thereby supporting force transmission between neighboring cells.
This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin.
TGF-beta3 (show TGFB3 Proteins) induces the chondrogenic differentiation of pericytes by inducing Wnt (show WNT2 Proteins)/beta-catenin signaling and T-cell factor-induced gene transcription.
cAMP/PKA regulation of GSK3beta/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.
Palmatin effect on osteoarthritis is likely mediated via the Wnt (show WNT2 Proteins)/beta-catenin and Hedgehog (show SHH Proteins) signaling
These results collectively showed that 2-Deoxy-D-glucose regulates dedifferentiation via beta-catenin pathway in rabbit articular chondrocytes.
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
catenin beta 1 subunit
, catenin beta-1
, beta catenin 1
, catenin (cadherin-associated protein), beta 1, 88kDa
, catenin beta-1-like
, catenin (cadherin associated protein), beta 1, 88kDa
, catenin beta
, beta catenin