Browse our CTNNB1 Proteins (CTNNB1)

Horse (Equine) Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. significantly increased gene expression in early osteochondrosis osteochondral junction chondrocytes compared to controls

2. temporal expression of CTNNB1 mRNA during dermal wound repair in the horse

Mouse (Murine) Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. This study show that beta-catenin in excitatory neurons of the adult neocortex is essential for the optimal processing of visual information.

2. nuclear organization of motor neurons is dependent on inside-out positioning, orchestrated by N-cadherin, catenin, and afadin activities, controlling cell body layering on the medio-lateral axis.

3. these indicate that SLIT3/ROBO2 promotes chondrocyte maturation via the inhibition of beta-catenin signaling.

4. mechanical unloading decreases MACF1 expression, and MACF1 up-regulates osteoblast proliferation through enhancing beta-catenin signaling. This study has thus provided a mechanism for mechanical unloading-induced inhibited osteoblast proliferation.

5. beta-catenin, which acts as a positive regulator of osteogenic differentiation, was negatively regulated by miR-92a1-5p.

6. we identified beta-catenin as a central player in maintaining Treg function and regulating the production of both IFN-gamma and IL-10 cytokines

7. TP53INP2 modulates adipogenesis through autophagy-dependent sequestration of GSK3beta into late endosomes and beta catenin activation, regulating adiposity.

8. The association of specific modifications of beta-catenin during normal lung development and again in response to lung injury supports the widely held concept that repair of lung injury involves the recapitulation of developmental programs.

9. beta-catenin inactivation in GLAST-expressing cells enhanced anxious/depressive-like responses.

10. Gfi1b regulates the level of Wnt3a/beta-catenin signaling in hematopoietic stem cells and megakaryocytes.

11. variations in Wnt/Beta-catenin signaling activity contribute to the severity of the osteochondroma phenotype by affecting both, osteochondroma size and number, in distinct manners.

12. This is the first demonstration of a reciprocal interaction between beta-catenin and Osx and the first report to show that a pathway downstream of Osx that signals through Tcf/Lefs is critical for cementogenesis during tooth development.

13. Intriguingly, Wnt3a, a Wnt/beta-catenin signalling ligand, significantly inhibited Mycobacterium bovis Bacillus Calmette-Guerin (BCG)-induced autophagy, with decreased autophagy rates and autophagic flux.

14. Major findings of the last decade document that Wnt/beta-catenin signaling in partnership with glial cells is critically involved in each step and at every level in the regulation of nigrostriatal dopaminergic neuronal health, protection, and regeneration in in the MPTP mouse model of Parkinson's disease. (Review)

15. It has been shown that the Wnt3a/beta-catenin/BDNF axis in the spinal neural circuit plays an important role in regulating capsaicin-induced pain.

16. mitochondria support osteoblast differentiation by promoting beta-catenin acetylation and activity

17. High CTNNB1 expression is associated with kidney fibrosis.

18. Results demonstrate that pituitary progenitors remain sensitive to both loss and gain of beta-catenin at this time point, and that either manipulation results in hypopituitarism.

19. High CTNNB1 expression is associated with breast cancer.

20. Low CTNNB1 expression promotes lung metastasis in osteosarcoma.

Zebrafish Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. Studied apoptosis and the Wnt/beta-catenin pathway in the cases of bisphenol A (BPA) and di(2-ethylhexyl) phthalate (DEHP) exposure in zebrafish embryos.

2. Wnt/beta-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling in the process of neovascularization of the central nervous system and blood-brain barrier formation.

3. The results demonstrate that the argon plasma jet has no adverse effects on fin regeneration and embryogenesis in zebrafish, and does not interrupt the (Wnt)/beta-Catenin-signaling pathways.

4. The expression of c-kit and beta-catenin suggests that erythropoietin may exert a role in regeneration reducing the extent of tubular damage from the outset after gentamicin administration.

5. Net1-regulated beta-catenin activation plays a crucial role in the dorsal axis formation during zebrafish development.

6. Wnt/beta-catenin signaling induces expression of col12a1a/b and deposition of Collagen XII, which is necessary for axons to actively navigate the non-neural lesion site environment.

7. Mechanistically, Hif-3alpha2 binds to beta-catenin and destabilizes the nuclear beta-catenin complex.

8. Nuclear beta-catenin is an indication of an activated Wnt pathway, therefore suggesting a possible role for Wnt signalling during zebrafish tooth development and replacement.

9. Findings suggest that microRNA 19b (miR-19b) regulates laterality development and heart looping in embryos by targeting beta-catenin ctnnb1.

10. Custos binds to beta-catenin in a Wnt responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.

11. The role of the beta-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila.

12. The Wnt/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality. (Review)

13. This study demonstrated that beta-catenin/Wnt signaling is initially required to activate cell-cycle re-entry in Muller glia following injury and that Wnt signaling subsequently controls the fate of the progeny of those cell divisions.

14. A novel role for Eaf1 and Eaf2 in inhibiting canonical Wnt/beta-catenin signaling, which might form the mechanistic basis for Eaf1 and Eaf2 tumor suppressor activity.

15. Ccr7 functions during axis formation as a GPCR to inhibit beta-catenin, likely by promoting Ca(2+) transients throughout the blastula.

16. ctnnb1 and ctnnb2 regulate multiple processes of laterality development in zebrafish embryos through similar and distinct mechanisms.

17. 2-OST functions within the Wnt pathway, downstream of Wnt ligand signaling and upstream of Gsk3beta and beta-catenin intracellular localization and function

18. It was shown that Wnt3a-Wnt8a/beta-catenin signaling directly regulates ciliogenic transcription factor foxj1a expression and ciliogenesis in zebrafish Kupffer's vesicle.

19. A Disc1 peptide binds to GSK3beta, and Disc1 directs early brain development and neurogenesis, by promoting beta-catenin-mediated Wnt signaling and inhibiting GSK3beta activity.

20. Foxo3b played a very important role in embryogenesis and negatively regulated maternal and zygotic Wnt/beta-catenin signaling by directly interacting with both beta-catenin1 and beta-catenin2.

Xenopus laevis Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. We identified the amphibian leap2 gene which is highly related to its mammalian orthologues at both structural and sequence levels. The gene is expressed in the embryo mostly in the endoderm-derived tissues. Accordingly it is induced in pluripotent animal cap cells by FGF, activin or a combination of vegT/beta-catenin.

2. Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A and thereby down-regulating the Wnt/beta-catenin signaling.

3. maternal Wnt/STOP signaling, but not beta-catenin signaling, has a role in cleavage after fertilization and cell cycle progression

4. Custos binds to beta-catenin in a Wnt responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.

5. Wnt signalling can benefit from nucleo-cytoplasmic shuttling of APC, Axin and GSK3, although they are in general beta-catenin antagonising proteins.

6. Phosphoinositide 3-kinase and Rac polarization depend specifically on the N-cadherin-p120 catenin complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin-beta-catenin complex.

7. HERG channel activity is stimulated by beta-catenin

8. Zic3 can suppress Wnt/beta-catenin signaling and control development of the notochord and Spemann's organizer.

9. Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3

10. The tyrosine kinase receptor, PTK7, is implicated in beta-catenin-dependent developmental processes.

11. Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity.

12. Activated Xenopus CTNNB1 regulates embryonic limb development via FGF signaling

13. data demonstrate a positive role for protein phosphatase 2A:B56epsilon in the Wnt/beta-catenin signaling pathway

14. Data support a mechanism in which maternal XSOX3 inhibits beta-catenin-mediated axis specification by repressing expression of Xnr5.

15. Chordin, Noggin, beta-Catenin, and Cerberus have roles in neural induction in Xenopus

16. Sox17 and beta-catenin interact to transcribe endodermal target genes

17. The localized activation of Wnt/beta-catenin signaling, which converts Tcf from a repressor to an activator, is required for the establishment of dorsal-ventral patterning in the prospective diencephalon.

18. Expression of Btg-x protein is regulated by both beta-Catenin and Nodal-related signals.

19. High activity of beta catenin led to efficient cell sorting from the notochord to the somites, whereas reduced activity led to sorting in the opposite direction.

20. Tcf/Lef genes encode factors of different activities, which function together in antagonistic or synergistic ways to modulate the intensity and outcome of Wnt/beta-catenin signalling and to trigger tissue-specific responses.

Human Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. Results show that Akt1-deficient endothelial cells exhibited increased phosphorylation and nuclear translocation of phosphorylated beta-catenin.

2. These findings provide new insights into a mechanism of miR-152 involved in beta-catenin and PKM2 inhibition.

3. We further confirmed absence of Sox9 expression in nuclear beta-catenin accumulating cells of adamantinomatous craniopharyngioma. Our results point to the conclusion that Sox2 and Sox9, seem to play essential roles not only in the specific formation of aCP, but also in processes involving the cerebral tumour environment, which needs to be illuminated in the future.

4. this study shows that thyroid hormone promotes beta-catenin activation and cell proliferation in colorectal cancer

5. miR-103/107-Wnt3a/beta-catenin-ATF6 pathway is critical to the progression of apoptosis in preadipocytes, which suggested that approaches to activate miR-103/107 could potentially be useful as new therapies for treating obesity and metabolic syndrome-related disorders

6. The data suggest that germline truncating mutations in CTNNB1 cause autosomal dominant syndromic familial exudative vitreoretinopathy (FEVR) or Norrie disease.

7. Circ_0001946 regulated SIRT1/Wnt/beta-catenin signaling pathway.

8. WISP3 inhibited the translocation of beta-catenin to the nucleus by activating glycogen synthase kinase-3beta (GSK3beta). Moreover, constitutively active beta-catenin blocked the suppressive effects of WISP3 on hepatocellular carcinoma.

9. SP1 and beta-catenin cooccupy the promoters of TCFL2/beta-catenin target genes.

10. expression did not differ between low-grade and high-grade serous ovarian carcinoma

11. multiomics analysis of a defined colorectal cancer cell model provides a significantly more comprehensive identification of functional molecular networks associated with oncogenic beta-catenin signaling.

12. MiR-506 inhibits tumor growth and metastasis in NPC via inhibition of Wnt/beta-catenin signaling by down-regulating LHX2.

13. Overexpressed LINC00968 contributes to reduced drug resistance in breast cancer cells by inhibiting the activation of the Wnt2/beta-catenin signaling pathway through silencing WNT2.

14. The expression of beta-catenin in placenta accreta might play an important role in the regulation of placental cell invasion; low expression of beta-catenin in placenta accreta might be responsible for excessive trophoblastic invasion.

15. The overexpression of OTUD6B-AS1 decreased the activity of the Wnt/beta-catenin pathway.

16. demonstrated the tumor suppressive lncRNA, Linc00320, is down-regulated in Glioma tissues and inhibits Glioma cell proliferation by restraining Wnt/beta-catenin signaling through segregating beta-catenin and TCF4 and revealed the novel HMGB1/Linc00320/beta-catenin axis in Glioma progression

17. High CTNNB1 expression is associated with epithelialtomesenchymal transition of glioma cells.

18. Both aberrant beta-catenin and AR positivity were associated with higher tumor grade and muscle invasion in urothelial carcinoma.

19. the present results demonstrated that upregulation of miRNA-33b may promote Ems via Wnt/beta-catenin by ZEB1 expression. Thus, restoration of miRNA-33b expression may be used as a novel strategy for the treatment of Ems, although this requires further investigation.

20. we have shown that the beta-catenin-Snail1-Twist transcription factor cluster is activated in smokers and especially in COPD in epithelial basal cells, and that their expression is remarkably closely related to both EMT activity and airway obstruction.

Pig (Porcine) Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. Results highlight a potential role for the beta-catenin/Wnt and Notch signalling pathways during the infection of crypt cells by L. intracellularis.

2. Flutamide exposure led to decreased beta-catenin in corpus luteum of mid/late pregnancy.

3. beta-catenin signaling is involved in formation of contractile membranes by dedifferentiated retinal pigment epithelium cells.

4. Wnt3a produced a significant increase in heart valve interstitial cell number at day 4 and in the percentage of BrdU-positive nuclei at 24 h. The increase in proliferation was abolished by beta-catenin siRNA.

5. This study tested whether prenatal and neonatal exposure to antiandrogen flutamide affected ovarian 17beta-estradiol synthesis and the associated gene expression in large antral follicles of adult pigs.

6. beta-catenin controls myocardin-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes

7. beta-Catenin plays a critical role in mediating TGF-beta1-induced myofibroblast differentiation in aortic valve interstitial cells.

8. scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of Glycogen synthase kinase 3beta activity which can lead to activation of the downstream signaling through beta-catenin

9. Data show that Wnt3a can inhibit the adipogenic differentiation of porcine AMSCs, and suggest that Wnt/beta-catenin signaling inhibits adipogenic differentiation potential and alters the cell fate from adipocytes to osteoblasts.

10. TNF-alpha inhibits adipogenesis through stabilization of beta-catenin protein in porcine preadipocytes.

Cow (Bovine) Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. Bovine herpesvirus 1 transiently increased beta-catenin protein levels in bovine kidney cells, but not in rabbit skin cells.

2. These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.

3. beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves.

4. These data demonstrate for the first time that FSH regulates CTNNB1 protein and WNT2 mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT signaling in ovarian steroidogenesis and follicular growth of cattle.

5. These data provide evidence that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin-targeted genes and myogenesis in the muscle-derived stem cells of cattle.

6. that beta-catenin is a plasma membrane-associated protein in airway smooth muscle that regulates active tension development, presumably by stabilizing cell-cell contacts and thereby supporting force transmission between neighboring cells.

7. This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin.

8. TGF-beta3 induces the chondrogenic differentiation of pericytes by inducing Wnt/beta-catenin signaling and T-cell factor-induced gene transcription.

9. cAMP/PKA regulation of GSK3beta/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.

Rabbit Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) interaction partners

1. Palmatin effect on osteoarthritis is likely mediated via the Wnt/beta-catenin and Hedgehog signaling

2. These results collectively showed that 2-Deoxy-D-glucose regulates dedifferentiation via beta-catenin pathway in rabbit articular chondrocytes.