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Human CTNNB1 Protein expressed in Wheat germ - ABIN1350670
Bian, Bai, Chapin, Le Moellic, Dong, Caplan, Sigworth, Navaratnam: Interactions between ?-catenin and the HSlo potassium channel regulates HSlo surface expression. in PLoS ONE 2011
Human CTNNB1 Protein expressed in Baculovirus infected Insect Cells - ABIN2004177
Hülsken, Birchmeier, Behrens: E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. in The Journal of cell biology 1995
Show all 6 Pubmed References
temporal expression of CTNNB1 mRNA during dermal wound repair in the horse
Study validates the DNAJB1 (show DNAJB1 Proteins)-PRKACA (show PRKACA Proteins) fusion kinase as an oncogenic driver and candidate drug target for fibrolamellar hepatocellular carcinoma in mouse model in which tumorigenesis was significantly enhanced by genetic activation of beta-catenin.
BCAS2 (show BCAS2 Proteins) is an upstream regulator of beta-catenin gene expression and plays a role in dendrite growth at least partly through beta-catenin in the forebrain.
LncRNA MALAT1 is dysregulated in diabetic nephropathy and involved in high glucose-induced podocyte injury via its interplay with beta-catenin and SRSF1 (show SRSF1 Proteins).
These findings suggest a suppressive function for Ctbp2 (show CTBP2 Proteins) in reducing the protein level of beta-catenin, along with priming its position on core pluripotency genes to hinder beta-catenin deposition, which is central to commitment to the appropriate lineage.
Beta-catenin deletion in cathepsin K (CtsK (show CTSK Proteins))-expressing cells causes a severe loss of bone mass.
the GSK-3beta/beta-catenin signal pathway mediates the adverse effects of Ti particles on osteoblast differentiation and bone destruction
HIV and drug abuse mediate astrocyte senescence in a beta (show SUCLA2 Proteins)-catenin-dependent manner leading to neuronal toxicity.
The absence of hepatic beta-catenin predisposes mice to hepatic injury and fibrosis following iron overload, which was reminiscent of hemochromatosis (show HFE Proteins) and associated with enhanced steatohepatitis and fibrosis.
beta-catenin and p65 (show NFkBP65 Proteins) are activated in separate cellular compartments during liver regeneration, with p65 (show NFkBP65 Proteins) activity in nonparenchymal compartment contributing to the activation of hepatocyte beta-catenin, cyclin D1 (show CCND1 Proteins) expression, and subsequent proliferation
beta-catenin mutations were not involved in early-stage hepatocarcinogenesis induced by protoporphyrinogen oxidase (show PPOX Proteins) inhibitors
The results demonstrate that the argon plasma jet (show FBXL15 Proteins) has no adverse effects on fin regeneration and embryogenesis in zebrafish, and does not interrupt the (Wnt (show WNT2 Proteins))/beta-Catenin-signaling pathways.
The expression of c-kit and beta-catenin suggests that erythropoietin (show EPO Proteins) may exert a role in regeneration reducing the extent of tubular damage from the outset after gentamicin administration.
Net1-regulated beta-catenin activation plays a crucial role in the dorsal axis formation during zebrafish development.
Wnt (show WNT2 Proteins)/beta-catenin signaling induces expression of col12a1a/b and deposition of Collagen XII, which is necessary for axons to actively navigate the non-neural lesion site environment.
Mechanistically, Hif-3alpha2 binds to beta-catenin and destabilizes the nuclear beta-catenin complex.
Nuclear beta-catenin is an indication of an activated Wnt (show WNT2 Proteins) pathway, therefore suggesting a possible role for Wnt (show WNT2 Proteins) signalling during zebrafish tooth development and replacement.
Findings suggest that microRNA 19b (miR (show MYLIP Proteins)-19b) regulates laterality development and heart looping in embryos by targeting beta-catenin ctnnb1.
Custos binds to beta-catenin in a Wnt (show WNT2 Proteins) responsive manner without affecting its stability, but rather modulates the cytoplasmic to nuclear translocation of beta-catenin.
The role of the beta-catenin mechanosensitive pathway in mesoderm identity has been conserved over the large evolutionary distance separating zebrafish and Drosophila.
The Wnt (show WNT2 Proteins)/beta-catenin signaling pathway establishes neuroanatomical asymmetries and their laterality. (Review)
We identified the amphibian leap2 (show LEAP2 Proteins) gene which is highly related to its mammalian orthologues at both structural and sequence levels. The gene is expressed in the embryo mostly in the endoderm-derived tissues. Accordingly it is induced in pluripotent animal cap cells by FGF, activin or a combination of vegT/beta-catenin.
Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A (show PPP2R2B Proteins) and thereby down-regulating the Wnt (show WNT2 Proteins)/beta-catenin signaling.
maternal Wnt (show WNT2 Proteins)/STOP signaling, but not beta-catenin signaling, has a role in cleavage after fertilization and cell cycle progression
Wnt (show WNT2 Proteins) signalling can benefit from nucleo-cytoplasmic shuttling of APC (show APC Proteins), Axin (show AXIN1 Proteins) and GSK3, although they are in general beta-catenin antagonising proteins.
Phosphoinositide 3-kinase and Rac (show AKT1 Proteins) polarization depend specifically on the N-cadherin (show CDH2 Proteins)-p120 catenin (show CTNND1 Proteins) complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin (show CDH2 Proteins)-beta-catenin complex.
HERG (show KCNH2 Proteins) channel activity is stimulated by beta-catenin
Zic3 (show ZIC3 Proteins) can suppress Wnt (show WNT2 Proteins)/beta-catenin signaling and control development of the notochord and Spemann's organizer.
Notch initially destabilises beta-catenin in a process that does not depend on its phosphorylation by GSK3
The tyrosine kinase receptor (show KDR Proteins), PTK7 (show PTK7 Proteins), is implicated in beta-catenin-dependent developmental processes.
Data show that alteration in beta-catenin expression, a core component of the CDH17/beta-catenin axis, in tumors affects serine peptidase inhibitor Kazal type 1 (SPINK1 (show SPINK1 Proteins)) serum levels in hepatocellular carcinoma (HCC (show FAM126A Proteins)) patients.
Subsequent experiments documented that activation of EGFR (show EGFR Proteins) signaling induced by PD98059 increased the amount of beta-catenin in the nucleus. Taken together, our findings may elucidate a possible mechanism explaining the ineffectiveness of MEK (show MAP2K1 Proteins) inhibitors in breast cancer treatment and improve our understanding of the role of MEK (show MAP2K1 Proteins) in cancer
Although Genome-Wide Association studies have not been carried out in the field of alcohol-related hepatocellular carcinoma (HCC (show FAM126A Proteins)), common single nucleotide polymorphisms conferring a small increase in the risk of liver cancer risk have been identified. Specific patterns of gene mutations including CTNNB1, TERT (show TERT Proteins), ARID1A and SMARCA2 (show SMARCA2 Proteins) exist in alcohol-related HCC (show FAM126A Proteins). [review]
PAK1 (show PAK1 Proteins) expression, evaluated by immunohistochemistry, was positively correlated with pERK (show EIF2AK3 Proteins) and beta-catenin expression in lung tumors. Patients with high-PAK1 (show PAK1 Proteins), high-pERK (show EIF2AK3 Proteins), and high-nuclear beta-catenin tumors more frequently showed an unfavorable response to cisplatin-based chemotherapy when compared to their counterparts.
We conclude that a combined analysis of beta-catenin and p53 (show TP53 Proteins) could have prognostic importance as markers for predicting the progression of colorectal cancer and contribute to the identification of patients with a high risk of mortality
This study demonstrated that Desmoid-type fibromatosis carrying T41A or S45F mutations and WT beta-catenin are two distinct molecular subgroups with regard to beta-catenin stability, alpha-catenin (show CTNNA1 Proteins) affinity, and gene expression profiling.
Odd-skipped related 1 (OSR1 (show OSR1 Proteins)) downregulated the activity of the Wnt (show WNT2 Proteins) signaling pathway by suppressing the expression of sex-determining region Y (show SRY Proteins)-box 9 (SOX9 (show SOX9 Proteins)) and beta-catenin.
Data show that plakoglobin (show JUP Proteins) interacted with p53R175H and decreased beta-catenin protein levels.
beta-Catenin is important in the pathogenesis of salivary gland pleomorphic adenomas and adenoid cystic carcinomas
These results suggested that increased ANXA2 (show ANXA2 Proteins) and less expressed beta-catenin were correlated to adenomyosis-associated dysmenorrhea
Results highlight a potential role for the beta-catenin/Wnt (show WNT2 Proteins) and Notch (show NOTCH1 Proteins) signalling pathways during the infection of crypt cells by L. intracellularis.
Flutamide exposure led to decreased beta-catenin in corpus luteum of mid/late pregnancy.
beta-catenin signaling is involved in formation of contractile membranes by dedifferentiated retinal pigment epithelium cells.
Wnt3a (show WNT3A Proteins) produced a significant increase in heart valve interstitial cell number at day 4 and in the percentage of BrdU-positive nuclei at 24 h. The increase in proliferation was abolished by beta-catenin siRNA.
beta-catenin controls myocardin-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes
beta-Catenin plays a critical role in mediating TGF-beta1 (show TGFB1 Proteins)-induced myofibroblast differentiation in aortic valve interstitial cells.
scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of Glycogen synthase kinase 3beta activity which can lead to activation of the downstream signaling through beta-catenin
Data show that Wnt3a (show WNT3A Proteins) can inhibit the adipogenic differentiation of porcine AMSCs, and suggest that Wnt (show WNT2 Proteins)/beta-catenin signaling inhibits adipogenic differentiation potential and alters the cell fate from adipocytes to osteoblasts.
TNF-alpha (show TNF Proteins) inhibits adipogenesis through stabilization of beta-catenin protein in porcine preadipocytes.
Bovine herpesvirus 1 transiently increased beta-catenin protein levels in bovine kidney cells, but not in rabbit skin cells.
These results demonstrate that activation of AKT (show AKT1 Proteins) is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.
beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves.
These data demonstrate for the first time that FSH (show BRD2 Proteins) regulates CTNNB1 protein and WNT2 (show WNT2 Proteins) mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT (show WNT2 Proteins) signaling in ovarian steroidogenesis and follicular growth of cattle.
These data provide evidence that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin-targeted genes and myogenesis in the muscle-derived stem cells of cattle.
that beta-catenin is a plasma membrane-associated protein (show PDZK1IP1 Proteins) in airway smooth muscle that regulates active tension development, presumably by stabilizing cell-cell contacts and thereby supporting force transmission between neighboring cells.
This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin.
TGF-beta3 (show TGFB3 Proteins) induces the chondrogenic differentiation of pericytes by inducing Wnt (show WNT2 Proteins)/beta-catenin signaling and T-cell factor-induced gene transcription.
cAMP/PKA regulation of GSK3beta/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.
Palmatin effect on osteoarthritis is likely mediated via the Wnt (show WNT2 Proteins)/beta-catenin and Hedgehog (show SHH Proteins) signaling
These results collectively showed that 2-Deoxy-D-glucose regulates dedifferentiation via beta-catenin pathway in rabbit articular chondrocytes.
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
catenin beta 1 subunit
, catenin beta-1
, beta catenin 1
, catenin (cadherin-associated protein), beta 1, 88kDa
, catenin beta-1-like
, catenin (cadherin associated protein), beta 1, 88kDa
, catenin beta
, beta catenin