CTNNB1 Protein (His tag)
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- Target See all CTNNB1 Proteins
- CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This CTNNB1 protein is labelled with His tag.
- Purpose
- Human Catenin beta-1 Protein, His Tag (MALS verified)
- Sequence
- Asn 138 - Glu 686
- Characteristics
- Human Catenin beta-1 Protein, His Tag is expressed from E. coli cells. It contains AA Asn 138 - Glu 686 (Accession # P35222-1).
- Purity
- 95 %
- Endotoxin Level
- 1.0 EU per μg
- Grade
- MALS verified
- Top Product
- Discover our top product CTNNB1 Protein
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Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 1-781) protein (GST tag)
CTNNB1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 682-781) protein (GST tag)CTNNB1 Origin: Human Host: Wheat germ Recombinant ELISA, WB, AA, AP
Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) protein (GST tag,His tag)CTNNB1 Origin: Mouse Host: Baculovirus infected Insect Cells Recombinant > 90 % as determined by SDS-PAGE
Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 2-781), (partial) protein (GST tag)CTNNB1 Origin: Human Host: Escherichia coli (E. coli) Recombinant 95 % ELISA
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- Comment
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This protein carries a polyhistidine tag at the N-terminus. (10xHis) The protein has a calculated MW of 62.1 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE).
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS
- Storage
- -80 °C
- Storage Comment
- -70°C
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- Target
- CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))
- Alternative Name
- Catenin beta-1 (CTNNB1 Products)
- Synonyms
- Jup Protein, LOC100217813 Protein, CTNNB1 Protein, CTNNB Protein, Bfc Protein, Catnb Protein, Mesc Protein, ctnnb Protein, id:ibd2058 Protein, wu:fb73e10 Protein, wu:fi81c06 Protein, wu:fk25h01 Protein, ctnnb1 Protein, CHBCAT Protein, MRD19 Protein, armadillo Protein, beta-catenin Protein, catenin beta 1 Protein, catenin (cadherin associated protein), beta 1 Protein, catenin (cadherin-associated protein), beta 1 Protein, catenin beta 1 S homeolog Protein, catenin beta 1 L homeolog Protein, CTNNB1 Protein, Ctnnb1 Protein, ctnnb1 Protein, ctnnb1.S Protein, ctnnb1.L Protein
- Background
- Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling.
- Molecular Weight
- 62.1 kDa
- Pathways
- WNT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2
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