Browse our SFRP1 Proteins (SFRP1)

Full name:: Secreted Frizzled-Related Protein 1 Proteins (SFRP1)

On www.antibodies-online.com are 21 Secreted Frizzled-Related Protein 1 (SFRP1) Proteins from 9 different suppliers available. Additionally we are shipping SFRP1 Antibodies (143) and SFRP1 Kits (44) and many more products for this protein. A total of 216 SFRP1 products are currently listed.

Synonyms:: 2210415K03Rik, AW011917, AW107218, AW742929, CSFRP1, FRP, FRP-1, FRP1, FrzA, LOC100231868, SARP2, sFRP-1, sfrp1, XfrzA

list all proteins	Gene Name	GeneID	UniProt
	SFRP1	6422	Q8N474
	SFRP1	20377	Q8C4U3
	SFRP1	84402
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SFRP1 Proteins (SFRP1) by Origin

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Human Secreted Frizzled-Related Protein 1 (SFRP1) interaction partners

Methylation of SFRP1, SFRP2 (show SFRP2 Proteins), SDC2 (show SDC2 Proteins), and PRIMA1 (show PRIMA1 Proteins) promoter sequences was observed in 85.1%, 72.3%, 89.4%, and 80.9% of plasma samples from patients with Colorectal cancer and 89.2%, 83.8%, 81.1% and 70.3% from adenoma patients, respectively.
preliminary data show loss of SFRP1 protein expression caused by the SFRP1 promoter hypermethylation in a subset of high-grade serous ovarian carcinomas
Loss of SFRP1 likely contributes to tumor progression by altering the expression of a critical transcription factor in both the epithelium and the immune system.
Authors found that downregulation of HP1alpha (show CBX5 Proteins) can decrease H3K9me3 enrichment and DNA methylation (show HELLS Proteins) rate of secreted frizzled-related protein 1 (SFRP1) promoter, resulting in restoring the expression of SFRP1.
KL and SFRP1 methylation were more predominant in nasopharyngeal tumors.
Results indicate that SFRP1 rs7832767 C > T, CTNNB1 (show CTNNB1 Proteins) rs2293303 C > T, and WISP1 (show WISP1 Proteins) rs16893344 C > T were all strongly correlated with myocardial infarction (MI) susceptibility.
miR (show MLXIP Proteins)-1254 promotes lung cancer cell proliferation by targeting the expression of SFRP1.
The expression of Dicer (show DICER1 Proteins) negatively correlated with that of SFRP1 and it appeared to promote CCA (show FBN2 Proteins) cell proliferation.
H2O2-induced SFRP1 gene demethylation contributes to H2O2-induced apoptosis in human U251 glioma cells.
Data suggest that microRNA miR (show MLXIP Proteins)-27a may activate the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway by negatively regulating SFRP1 to promote the proliferation, migration and invasion of breast cancer (BC) cells.

Mouse (Murine) Secreted Frizzled-Related Protein 1 (SFRP1) interaction partners

Loss of SFRP1 likely contributes to tumor progression by altering the expression of a critical transcription factor in both the epithelium and the immune system.
OVOL1 (show OVOL1 Proteins)-regulated Fst (show FST Proteins) and SFRP1 affect hair inductive potency of neonatal dermal cells.
Down stream actions of estrogen-mediated signaling, including cellular proliferation and progesterone receptor (show PGR Proteins) transcription, are elevated in estradiol treated explant cultures derived from Sfrp1(-/-) mice.
Study suggests that the induction of the WNT (show WNT2 Proteins) pathway is a potentially crucial pathway in the development of cardiomyopathy with aging with sFRP-1 being a critical factor in maintaining normal cardiovascular structure and function during this process.
the expression of Sfrp1 is a critical factor required for maintaining appropriate cellular signaling in response to the onset of obesity
findings suggest that SFRP1 expression in the adult maintains progenitor cells within their undifferentiated state and suggests that manipulation of this pathway is a potential target to augment the lung repair process during disease
Sfrp1 is required for inhibition of renal damage through the non-canonical Wnt (show WNT2 Proteins)/PCP (show BMP1 Proteins) pathway in a mouse model of obstructive nephropathy
SFRP1 deficiency in mice results in the development of diet-induced obesity aggravated by inflammation and breast cancer.
Sfrp1(-/-) mice have less DNA fragmentation, whilst caspase-3 (show CASP3 Proteins) expression is decreased, and that p53 (show TP53 Proteins) expression is generally diminished.
secreted FRP1 either inhibits or enhances signaling in the Wnt3a (show WNT3A Proteins)/beta-catenin (show CTNNB1 Proteins) pathway

Pig (Porcine) Secreted Frizzled-Related Protein 1 (SFRP1) interaction partners

Results show the expression level of SFRP1 significantly higher in the embryonic skeletal muscle and diminishes after, whereas miR-206/1 show the inverse. Also, SFRP1 gene is regulated by miR-1/206 and potentially affects skeletal muscle development.

SFRP1 Protein Profile

Protein Summary

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling\; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.

Alternative names and synonyms associated with SFRP1

secreted frizzled related protein 1 (SFRP1)
secreted frizzled-related protein 1 (sfrp1)
secreted frizzled related protein 1 (sfrp1)
Secreted frizzled-related protein 1 (sfrp1)
secreted frizzled-related protein 1 (Sfrp1)
secreted frizzled related protein 1 (Sfrp1)

2210415K03Rik protein
AW011917 protein
AW107218 protein
AW742929 protein
CSFRP1 protein
FRP protein
FRP-1 protein
FRP1 protein
FrzA protein
LOC100231868 protein
SARP2 protein
sFRP-1 protein
sfrp1 protein
XfrzA protein

Protein level used designations for SFRP1

secreted frizzled-related protein 1 , Secreted frizzled-related protein 1 , SARP-2 , sFRP-1 , secreted apoptosis-related protein 2 , secreted frizzled related protein 1 , frizzled in aorta protein , frzA protein , secreted frizzled-related sequence protein 1

GENE ID	SPECIES
702876	Macaca mulatta
736186	Pan troglodytes
100038100	Xenopus (Silurana) tropicalis
100049476	Oryzias latipes
100195490	Salmo salar
100231868	Taeniopygia guttata
100582389	Nomascus leucogenys
6422	Homo sapiens
395237	Gallus gallus
482844	Canis lupus familiaris
282068	Bos taurus
20377	Mus musculus
84402	Rattus norvegicus
100727192	Cavia porcellus
101121066	Ovis aries
100621622	Sus scrofa

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