Browse our SFRP1 Proteins (SFRP1)

Human Secreted Frizzled-Related Protein 1 (SFRP1) interaction partners

1. Patients with chronic periodontitis exhibit elevated expression of SFRP1 and beta-catenin in gingival tissues, and this event is related to the degree of periodontal destruction. Abnormal expression of SFRP1 and beta-catenin may promote the development of periodontitis.

2. MiR-208a enhances cell proliferation and invasion of gastric cancer by targeting SFRP1 and negatively regulating MEG3

3. sFRP1 overexpression promotes gastric cancer cell proliferation and metastasis by activating TGFbeta signaling; however, sFRP1 limits the growth inhibitory effect of TGFbeta signaling via Rac1 and GSK3beta.

4. active involvement in placental development and important role in pathology of pregnancy

5. SFRP1 gene was epigenetically silenced in glioblastomas when compared to low astrocytoma grades, which may suggest that the lack of its protein is involved in astrocytoma progression.

6. It has been found that miR-27a-3p modulated the Wnt/beta-catenin signaling pathway to promote epithelial-mesenchymal transition in oral squamous carcinoma stem cells by down-regulating SFRP1.

7. sFRP1 overexpression in gastric cancer cells leads to increased cell proliferation and angiogenesis.

8. Study determined that SFRP1 is downregulated during tumor formation probably by DNA methylation, and associates consistently with tumor suppressive functions.

9. co-transfection of sFRP1 siRNA with miR- 191 inhibitor sequence, it was found that the Wnt/beta-catenin signaling pathway was reactivated and the colony formation ability of RBE cells was restored.

10. WNT5b rs3803164, and SFRP1 rs3242 were significantly associated with lumbar spine BMD.

11. lost SFRP1 expression-induced Wnt/beta-catenin signaling due to the hypermethylation of the SFRP1 promoter could associate with keloid development

12. miR-1301-3p promoted the expansion of prostate cancer stem cells by inhibiting GSK3beta and SFRP1, and activating the Wnt pathway.

13. Methylation level of the SFRP1 promoter region is increased in patients with RCC compared to normal controls and might be involved in the occurrence and development of RCC.

14. Methylation of SFRP1, SFRP2, SDC2, and PRIMA1 promoter sequences was observed in 85.1%, 72.3%, 89.4%, and 80.9% of plasma samples from patients with Colorectal cancer and 89.2%, 83.8%, 81.1% and 70.3% from adenoma patients, respectively.

15. preliminary data show loss of SFRP1 protein expression caused by the SFRP1 promoter hypermethylation in a subset of high-grade serous ovarian carcinomas

16. Loss of SFRP1 likely contributes to tumor progression by altering the expression of a critical transcription factor in both the epithelium and the immune system.

17. Authors found that downregulation of HP1alpha can decrease H3K9me3 enrichment and DNA methylation rate of secreted frizzled-related protein 1 (SFRP1) promoter, resulting in restoring the expression of SFRP1.

18. KL and SFRP1 methylation were more predominant in nasopharyngeal tumors.

19. Results indicate that SFRP1 rs7832767 C > T, CTNNB1 rs2293303 C > T, and WISP1 rs16893344 C > T were all strongly correlated with myocardial infarction (MI) susceptibility.

20. miR-1254 promotes lung cancer cell proliferation by targeting the expression of SFRP1.

Mouse (Murine) Secreted Frizzled-Related Protein 1 (SFRP1) interaction partners

1. Low Sfrp1 expression is associated with pulmonary fibrosis.

2. The results of this study indicated that Shh, Sfrp1, and Wnt5a collaborate to direct the pathfinding of descending 5-HT axons in the brainstem

3. Loss of SFRP1 likely contributes to tumor progression by altering the expression of a critical transcription factor in both the epithelium and the immune system.

4. OVOL1-regulated Fst and SFRP1 affect hair inductive potency of neonatal dermal cells.

5. Down stream actions of estrogen-mediated signaling, including cellular proliferation and progesterone receptor transcription, are elevated in estradiol treated explant cultures derived from Sfrp1(-/-) mice.

6. Study suggests that the induction of the WNT pathway is a potentially crucial pathway in the development of cardiomyopathy with aging with sFRP-1 being a critical factor in maintaining normal cardiovascular structure and function during this process.

7. the expression of Sfrp1 is a critical factor required for maintaining appropriate cellular signaling in response to the onset of obesity

8. findings suggest that SFRP1 expression in the adult maintains progenitor cells within their undifferentiated state and suggests that manipulation of this pathway is a potential target to augment the lung repair process during disease

9. Sfrp1 is required for inhibition of renal damage through the non-canonical Wnt/PCP pathway in a mouse model of obstructive nephropathy

10. SFRP1 deficiency in mice results in the development of diet-induced obesity aggravated by inflammation and breast cancer.

11. Sfrp1(-/-) mice have less DNA fragmentation, whilst caspase-3 expression is decreased, and that p53 expression is generally diminished.

12. secreted FRP1 either inhibits or enhances signaling in the Wnt3a/beta-catenin pathway

13. Sfrp1 and Sfrp2 appear to have a positive regulatory function because Wnt/beta-catenin signaling in lens epithelial cells was reduced in Sfrp1 and Sfrp2 DKO mice

14. Reduced expression of Sfrp1 during chondrogenesis and in articular chondrocytes correlates with osteoarthritis.

15. studies indicate that mutations neither in sFRP1 nor in sFRP4 are a common cause of craniotubular hyperostoses

16. SFRP1 gene is critical for maintaining proper mammary gland development.

17. SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells.

18. expression of Pax6 is necessary and sufficient to render postmitotic neurons competent to respond to SFRP1 to increase axonal growth

19. Secreted frizzled-related protein-1 improves postinfarction scar formation through a modulation of inflammatory response.

20. wnt spreading is impaired in the retina of Sfrp1(-/-);Sfrp2(-/-) mice, but forced expression of Sfrp1 in the wing imaginal disc of Drosophila suppresses some effects of Wg

Pig (Porcine) Secreted Frizzled-Related Protein 1 (SFRP1) interaction partners

1. Results show the expression level of SFRP1 significantly higher in the embryonic skeletal muscle and diminishes after, whereas miR-206/1 show the inverse. Also, SFRP1 gene is regulated by miR-1/206 and potentially affects skeletal muscle development.