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The expression of Dicer (show DICER1 Proteins) negatively correlated with that of SFRP1 and it appeared to promote CCA (show FBN2 Proteins) cell proliferation.
H2O2-induced SFRP1 gene demethylation contributes to H2O2-induced apoptosis in human U251 glioma cells.
Data suggest that microRNA miR (show MLXIP Proteins)-27a may activate the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway by negatively regulating SFRP1 to promote the proliferation, migration and invasion of breast cancer (BC) cells.
Data indicate that microRNA miR (show MLXIP Proteins)-744 activated Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) pathway by targeting multiple negative regulators of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling, including SFRP1, GSK3beta, TLE3 and NKD1 (show NKD1 Proteins), and that NKD1 (show NKD1 Proteins) is a major functional target of miR (show MLXIP Proteins)-744.
Our results indicate that DKK1 (show DKK1 Proteins) and SFRP1 may be potentially useful biomarkers for evaluating the beneficial effects of long-term exercise on physical fitness and metabolism as well as the prognosis of patients with cancer.
MiR-1 (show FSD1 Proteins)-3p suppresses the proliferation, invasion and migration of bladder cancer cells by up-regulating SFRP1 expression.
SFRP1 mRNA expression was reduced by both resistant starch and polydextrose. Resistant starch and polydextrose did not affect SFRP1 methylation or alter the expression of 10 microRNAs predicted to target SFRP1.
Taken together, our results suggest that canonical Wnt signaling and its antagonist, sFRP1, regulate proliferation of human CSCs. Furthermore, excess sFRP1 in elderly patients causes CSC aging.
Genetic variants in the 3' untranslated region of sFRP1 gene is associated with risk of gastric cancer.
This study suggested mechanistic relationship between miR (show MLXIP Proteins)-940 and Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) in the development and progression of pancreatic carcinoma through regulation of GSK3beta and sFRP1.
OVOL1 (show OVOL1 Proteins)-regulated Fst (show FST Proteins) and SFRP1 affect hair inductive potency of neonatal dermal cells.
Down stream actions of estrogen-mediated signaling, including cellular proliferation and progesterone receptor (show PGR Proteins) transcription, are elevated in estradiol treated explant cultures derived from Sfrp1(-/-) mice.
Study suggests that the induction of the WNT (show WNT2 Proteins) pathway is a potentially crucial pathway in the development of cardiomyopathy with aging with sFRP-1 being a critical factor in maintaining normal cardiovascular structure and function during this process.
the expression of Sfrp1 is a critical factor required for maintaining appropriate cellular signaling in response to the onset of obesity
findings suggest that SFRP1 expression in the adult maintains progenitor cells within their undifferentiated state and suggests that manipulation of this pathway is a potential target to augment the lung repair process during disease
Sfrp1 is required for inhibition of renal damage through the non-canonical Wnt (show WNT2 Proteins)/PCP (show BMP1 Proteins) pathway in a mouse model of obstructive nephropathy
SFRP1 deficiency in mice results in the development of diet-induced obesity aggravated by inflammation and breast cancer.
Sfrp1(-/-) mice have less DNA fragmentation, whilst caspase-3 (show CASP3 Proteins) expression is decreased, and that p53 (show TP53 Proteins) expression is generally diminished.
secreted FRP1 either inhibits or enhances signaling in the Wnt3a (show WNT3A Proteins)/beta-catenin (show CTNNB1 Proteins) pathway
Sfrp1 and Sfrp2 (show SFRP2 Proteins) appear to have a positive regulatory function because Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in lens epithelial cells was reduced in Sfrp1 and Sfrp2 (show SFRP2 Proteins) DKO mice
Results show the expression level of SFRP1 significantly higher in the embryonic skeletal muscle and diminishes after, whereas miR-206/1 show the inverse. Also, SFRP1 gene is regulated by miR-1/206 and potentially affects skeletal muscle development.
This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling\; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina.
secreted frizzled-related protein 1
, Secreted frizzled-related protein 1
, secreted apoptosis-related protein 2
, secreted frizzled related protein 1
, frizzled in aorta protein
, frzA protein
, secreted frizzled-related sequence protein 1