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anti-Mouse (Murine) TCF7L1 Antibodies:
anti-Human TCF7L1 Antibodies:
anti-Rat (Rattus) TCF7L1 Antibodies:
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Human Polyclonal TCF7L1 Primary Antibody for ELISA, WB - ABIN566493
Kim, Kim, Lee, Kim, Baek, Kim, Kwon, Kim: Identification of replicative senescence-associated genes in human umbilical vein endothelial cells by an annealing control primer system. in Experimental gerontology 2008
Tcf7l1 defines the border between the neural crest and the prospective forebrain via restriction of the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling gradient.
report the identification of two independent missense variants in human TCF7L1, p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects
The authors find that downstream of glycogen synthase kinase 3 (show GSK3a Antibodies) inhibition, elevated cMyc (show MYC Antibodies) and beta-catenin (show CTNNB1 Antibodies) act in parallel to reduce transcription and DNA binding, respectively, of the transcriptional repressor Tcf7l1.
Sox4 and Tcf7l1 form a functional axis that promotes the progression of BCR-ABL (show ABL1 Antibodies)-positive acute lymphoblastic leukemia.
The role of Tcf7l1 in mammals is to inhibit the gene regulatory network to ensure the coordination of lineage specification with the dynamic cellular events occurring during gastrulation.
results establish TCF7L1 as a transcriptional hub coordinating cell-cell contact with the transcriptional repression required for adipogenic competency
Tcf3-/- embryos proceed through gastrulation to form mesoderm, but they develop expanded and often duplicated axial mesoderm structures, including nodes and notochords.
E2A (show TCF3 Antibodies)-PBX1 (show PBX1 Antibodies) interacts directly with the KIX domain of CBP/p300 (show CREBBP Antibodies) in the induction of proliferation in primary hematopoietic cells
Tcf3-mediated control of Nanog levels allows stem cells to balance the creation of lineage-committed and undifferentiated cells
These data suggest that in the absence of Wnt (show WNT2 Antibodies) signals, Tcf3 may function in skin SCs (show TWIST1 Antibodies) to maintain an undifferentiated state and, through Wnt (show WNT2 Antibodies) signaling, directs these cells along the hair lineage.
Through transcriptome profiling and combined gain- and loss-of-function studies, the authors identified LCN2 (show LCN2 Antibodies) as a major downstream effector of TCF7L1 (show TCF3 Antibodies) that drives tumor growth.
report the identification of two independent missense variants in human TCF7L1 (show TCF3 Antibodies), p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects
Data indicate that median methylation levels of BCAN (show BCAN Antibodies), HOXD1 (show HOXD1 Antibodies), KCTD8 (show KCTD8 Antibodies), KLF11 (show KLF11 Antibodies), NXPH1 (show NXPH1 Antibodies), POU4F1 (show POU4F1 Antibodies), SIM1 (show SIM1 Antibodies), and TCF7L1 (show TCF3 Antibodies) were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis.
No difference in nuclear beta-catenin (show CTNNB1 Antibodies) signal intensity was found, which may be caused by an alteration in Wnt (show WNT2 Antibodies) pathway in microsatellite stable sporadic tumors by unknown mechanisms leading to lower TCF-3 (show TCF3 Antibodies), 4 protein expression.
This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.
HMG box transcription factor 3
, T-cell factor 3
, transcription factor 3
, transcription factor 7-like 1
, transcription factor 7-like 1 (T-cell specific, HMG box)
, transcription factor 7-like 2 (T-cell specific, HMG box)
, HMG box transcription factor 3-A
, transcription factor 7-like 1-A
, transcription factor XTCF-3b