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anti-Human TCF7L1 Antibodies:
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Human Polyclonal TCF7L1 Primary Antibody for ELISA, WB - ABIN566493
Kim, Kim, Lee, Kim, Baek, Kim, Kwon, Kim: Identification of replicative senescence-associated genes in human umbilical vein endothelial cells by an annealing control primer system. in Experimental gerontology 2008
HIPK2 up-regulates transcription by phosphorylating TCF3, a transcriptional repressor, but inhibits transcription by phosphorylating LEF1, a transcriptional activator.
Tcf3is partially responsible for the butyrate-resistant phenotype of colorectal cancer cells, as this DNA-binding protein suppresses the hyperinduction of Wnt activity by butyrate.
Our results identify TCF3 as a central regulator of tumor growth and initiation.
TCF3, a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt signaling in different microenvironments.
TCF/TLE tetramer complex promotes structural transitions of chromatin to mediate repression.
These results indicate that a dynamic interplay of TCF transcription factors governs MYC gene expression in colorectal cancers.
TCF7L1, a Wnt pathway repressor, buffers CTNNB1/TCF target gene expression to promote CRC growth
TCF7L1 plays a major role in maintaining hESC pluripotency, which has implications for human development during gastrulation
Through transcriptome profiling and combined gain- and loss-of-function studies, the authors identified LCN2 as a major downstream effector of TCF7L1 that drives tumor growth.
report the identification of two independent missense variants in human TCF7L1, p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects
Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis.
No difference in nuclear beta-catenin signal intensity was found, which may be caused by an alteration in Wnt pathway in microsatellite stable sporadic tumors by unknown mechanisms leading to lower TCF-3, 4 protein expression.
Tcf7l1 defines the border between the neural crest and the prospective forebrain via restriction of the Wnt/beta-catenin signaling gradient.
results argue that during anterior-posterior patterning of the mesoderm Tcf7l1 proteins are cell autonomously required to limit Wnt signaling
Results indicate that Tcf7l1 plays an important role in spinal cord progenitor maintenance
This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.
HMG box transcription factor 3
, transcription factor 7-like 1
, T-cell factor 3
, transcription factor 3
, transcription factor 7-like 1 (T-cell specific, HMG box)
, transcription factor 7-like 2 (T-cell specific, HMG box)
, HMG box transcription factor 3-A
, transcription factor 7-like 1-A
, transcription factor XTCF-3b
, HMG-box transcription factor
, Protein headless
, protein headless
, transcription factor 7-like 1a (T-cell specific, HMG-box)
, transcription factor tcf3