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anti-Mouse (Murine) TCF7L1 Antibodies:
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Human Polyclonal TCF7L1 Primary Antibody for ELISA, WB - ABIN566493
Kim, Kim, Lee, Kim, Baek, Kim, Kwon, Kim: Identification of replicative senescence-associated genes in human umbilical vein endothelial cells by an annealing control primer system. in Experimental gerontology 2008
Tcf7l1 defines the border between the neural crest and the prospective forebrain via restriction of the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling gradient.
report the identification of two independent missense variants in human TCF7L1, p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects
The authors find that downstream of glycogen synthase kinase 3 (show GSK3a Antibodies) inhibition, elevated cMyc (show MYC Antibodies) and beta-catenin (show CTNNB1 Antibodies) act in parallel to reduce transcription and DNA binding, respectively, of the transcriptional repressor Tcf7l1.
Sox4 and Tcf7l1 form a functional axis that promotes the progression of BCR-ABL (show ABL1 Antibodies)-positive acute lymphoblastic leukemia.
The role of Tcf7l1 in mammals is to inhibit the gene regulatory network to ensure the coordination of lineage specification with the dynamic cellular events occurring during gastrulation.
results establish TCF7L1 as a transcriptional hub coordinating cell-cell contact with the transcriptional repression required for adipogenic competency
Tcf3-/- embryos proceed through gastrulation to form mesoderm, but they develop expanded and often duplicated axial mesoderm structures, including nodes and notochords.
E2A (show TCF3 Antibodies)-PBX1 (show PBX1 Antibodies) interacts directly with the KIX domain of CBP/p300 (show CREBBP Antibodies) in the induction of proliferation in primary hematopoietic cells
Tcf3-mediated control of Nanog levels allows stem cells to balance the creation of lineage-committed and undifferentiated cells
These data suggest that in the absence of Wnt (show WNT2 Antibodies) signals, Tcf3 may function in skin SCs (show TWIST1 Antibodies) to maintain an undifferentiated state and, through Wnt (show WNT2 Antibodies) signaling, directs these cells along the hair lineage.
HIPK2 (show HIPK2 Antibodies) up-regulates transcription by phosphorylating TCF3 (show TCF3 Antibodies), a transcriptional repressor, but inhibits transcription by phosphorylating LEF1 (show LEF1 Antibodies), a transcriptional activator.
Tcf3is partially responsible for the butyrate-resistant phenotype of colorectal cancer cells, as this DNA-binding protein (show UBE2V1 Antibodies) suppresses the hyperinduction of Wnt (show WNT2 Antibodies) activity by butyrate.
Our results identify TCF3 (show TCF3 Antibodies) as a central regulator of tumor growth and initiation.
TCF3 (show TCF3 Antibodies), a novel positive regulator of osteogenesis, plays a crucial role in miR-17 modulating the diverse effect of canonical Wnt (show WNT2 Antibodies) signaling in different microenvironments.
TCF (show HNF4A Antibodies)/TLE tetramer complex promotes structural transitions of chromatin to mediate repression.
These results indicate that a dynamic interplay of TCF (show HNF4A Antibodies) transcription factors governs MYC (show MYC Antibodies) gene expression in colorectal cancers.
TCF7L1 (show TCF3 Antibodies), a Wnt (show WNT2 Antibodies) pathway repressor, buffers CTNNB1 (show CTNNB1 Antibodies)/TCF (show HNF4A Antibodies) target gene expression to promote CRC (show CALR Antibodies) growth
TCF7L1 (show TCF3 Antibodies) plays a major role in maintaining hESC pluripotency, which has implications for human development during gastrulation
Through transcriptome profiling and combined gain- and loss-of-function studies, the authors identified LCN2 (show LCN2 Antibodies) as a major downstream effector of TCF7L1 (show TCF3 Antibodies) that drives tumor growth.
report the identification of two independent missense variants in human TCF7L1 (show TCF3 Antibodies), p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects
This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.
HMG box transcription factor 3
, T-cell factor 3
, transcription factor 3
, transcription factor 7-like 1
, transcription factor 7-like 1 (T-cell specific, HMG box)
, transcription factor 7-like 2 (T-cell specific, HMG box)
, HMG box transcription factor 3-A
, transcription factor 7-like 1-A
, transcription factor XTCF-3b