Browse our TLE1 Proteins (TLE1)

Full name:: Transducin-Like Enhancer of Split 1 (E(sp1) Homolog, Drosophila) Proteins (TLE1)

On www.antibodies-online.com are 4 Transducin-Like Enhancer of Split 1 (E(sp1) Homolog, Drosophila) (TLE1) Proteins from 3 different suppliers available. Additionally we are shipping TLE1 Antibodies (110) and and many more products for this protein. A total of 120 TLE1 products are currently listed.

Synonyms:: C230057C06Rik, esg, esg1, esg2, esg3, Estm14, Grg1, grg2, grg3, tle3, tle3a, Tle4l, Xesg1, xgrg3

list all proteins	Gene Name	GeneID	UniProt
Rat TLE1	TLE1	362533
	TLE1	7088	Q04724
	TLE1	21885	Q62440
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TLE1 Proteins (TLE1) by Origin

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Relevant Pathways for TLE1 Proteins

WNT Signaling

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More Proteins for TLE1 Interaction Partners

Human Transducin-Like Enhancer of Split 1 (E(sp1) Homolog, Drosophila) (TLE1) interaction partners

TLE1 is a potential immunohistochemical marker for glomus tumors
studies indicate Bit1 (show PTRH2 Proteins) is an inhibitor of EMT (show ITK Proteins) and metastasis in lung cancer and hence can serve as a molecular target in curbing lung cancer aggressiveness
Authors present data indicating that TLE1 is rapidly excluded from the nucleus following epidermal growth factor receptor (show EGFR Proteins) pathway activation, an effect that likely accounts for its inability to mediate effective repression under such conditions.
TLE1 is not a stand-alone diagnostic immunohistochemical marker for synovial sarcoma
Data suggest TLE1 is highly expressed in macrophages cultured in vitro, in macrophages of atherosclerotic plaques, and in macrophages of visceral adipose tissue from obese women; expression of TLE1 is up-regulated upon macrophage activat (show IL4 Proteins)ion.
TLE1 has a role in regulating epithelial-to-mesenchymal transition in A549 cells through its repressive effect on E-cadherin (show CDH1 Proteins)
There was no difference in TLE-1 staining between different subtypes of synovial sarcoma
GrG1 is involved in pancreatic cell differentiation, establishing a monohormonal beta cell identity. Grg1 is the predominant Groucho expressed in human beta-cells but acts functionally similarly to Grg3.
TCF (show HNF4A Proteins)/TLE tetramer complex promotes structural transitions of chromatin to mediate repression.
signaling and increases the expression (show NOTCH1 Proteins)of recombinant recognition sequence binding protein at the Jkappa site (RBP-J) and transducin-like enhancer of Split (show RBPJ Proteins)(TLE).

Mouse (Murine) Transducin-Like Enhancer of Split 1 (E(sp1) Homolog, Drosophila) (TLE1) interaction partners

Demethylation of TLE1 promoter region activates the self-expression in diabetic mice intestinal epithelium cells (IECs). Subsequently, TLE1, through the transcriptional suppression on expression of Hes1 (show HES1 Proteins), contributes to the aberrant differentiation of IECs in DM mice.

Data suggest that Tle1 is highly expressed in activated macrophages cultured in vitro; expression of Tle1 is low in resting macrophages and is up-regulated upon macrophage activation (here, stimulated with recombinant human interleukin-4 (show IL4 Proteins)).

Loss of Tle1 not only results in increased phosphorylation and activation of proinflammatory NF-kappaB but also results in decreased Hes1 (hairy and enhancer of split-1), a negative regulator of inflammation in macrophages

TLE1/TLE3-NuRD corepressor complex facilitates Tbx20 (show TBX20 Proteins)-dependent transcriptional repression.

Data indicate that cAMP activates Notch (show NOTCH1 Proteins) signaling and increases the expression of recombinant recognition sequence binding protein at the Jkappa site (RBP-J (show RBPJ Proteins)) and transducin (show GNAT1 Proteins)-like enhancer of Split (TLE).

Studies suggest that TLE1 and TLE3 might also play roles independent of HESX1 (show HESX1 Proteins) by interacting with other transcription factors like PROP1 (show PROP1 Proteins).

Grg1-S may operate in conjunction with beta-catenin (show CTNNB1 Proteins) and Tcf (show HNF4A Proteins) factors to regulate vertebrate gut (show GUSB Proteins) epithelial cell differentiation

Grg6 (show TLE6 Proteins) interferes with the binding of Gro (show CXCL1 Proteins)/TLE1 to BF-1 (show FOXG1 Proteins) and does not repress transcription when targeted to DNA.

Inhibition of cortical neuron differentiation by Groucho/TLE1 requires interaction with WRPW, but not Eh1 (show EPHX1 Proteins), repressor peptides

TLE1 Protein Profile

Protein Summary

Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

Alternative names and synonyms associated with TLE1

transducin like enhancer of split 1 (Tle1)

transducin-like enhancer protein 1 (Smp_150080)

transducin like enhancer of split 1 (TLE1)

transducin like enhancer of split 2b (tle2b)

transducin-like enhancer of split 1 (Tle1)

transducin like enhancer of split 2 L homeolog (tle2.L)

C230057C06Rik protein

esg protein

esg1 protein

esg2 protein

esg3 protein

Estm14 protein

Grg1 protein

grg2 protein

grg3 protein

tle3 protein

tle3a protein

Tle4l protein

Xesg1 protein

xgrg3 protein

Protein level used designations for TLE1

transducin-like enhancer of split 1 , transducin-like enhancer protein 1 , novel protein similar to vertebrate transducin-like enhancer family (E(sp1) homolog Drosophila) , e(Sp1) homolog , enhancer of split groucho 1 , enhancer of split groucho-like protein 1 , transducin-like enhancer of split 1, homolog of Drosophila E(sp1) , grg-1 , groucho-related protein 1 , transducin-like enhancer of split 4 (homolog of Drosophila E(spl)) - like , enhancer of split groucho , transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila) , transducin-like enhancer of split 3 (E(sp1) homolog) a

GENE ID SPECIES

362533 Rattus norvegicus

8346165 Schistosoma mansoni

427450 Gallus gallus

564019 Danio rerio

7088 Homo sapiens

21885 Mus musculus

398072 Xenopus laevis

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GENE ID	SPECIES
362533	Rattus norvegicus
8346165	Schistosoma mansoni
427450	Gallus gallus
564019	Danio rerio
7088	Homo sapiens
21885	Mus musculus
398072	Xenopus laevis