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24-Dehydrocholesterol Reductase Proteins (DHCR24)

DHCR24 encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. Additionally we are shipping Seladin 1 Antibodies (52) and Seladin 1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DHCR24 1718 Q15392
DHCR24 74754 Q8VCH6
DHCR24 298298  
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Top Seladin 1 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,305.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

DHCR24 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for 24-Dehydrocholesterol Reductase (DHCR24) Interaction Partners

Human 24-Dehydrocholesterol Reductase (DHCR24) interaction partners

  1. DHCR24 auto-antibody represents a potential noninvasive biomarker for hepatitis C virus-related liver disease and may facilitate the diagnosis of PIVKA-II and AFP (show AFP Proteins)-negative hepatocellular carcinoma.

  2. physical and functional interaction between DHCR24 and DHCR7 (show DHCR7 Proteins)

  3. In vitro experiments showed that DHCR24 overexpression induced tumor proliferation.

  4. Data (including data from studies using RNA from post-mortem brain tissue) suggest that expression of DHCR24 is up-regulated in parietal cortex of patients with Huntington's disease as compared to control subjects.

  5. Data indicate a mechanism whereby 3beta-hydroxysterol Delta24-reductase (DHCR24) activity is regulated by signaling.

  6. DHCR24 expression protects neuronal cells from apoptotic cell death induced by endoplasmic reticulum stress.

  7. TR-beta (show TXNRD2 Proteins) and LXR-alpha (show NR1H3 Proteins) competitively up-regulate the human Seladin-1 promoter, sharing the same response element, site A.

  8. DHCR24 gene expression is regulation by cholesterol availability.

  9. a novel role for 24,25EC in cholesterol homeostasis, through its rapid inhibition of cholesterol synthesis at DHCR24.

  10. a gender dependent effect of DHCR24 rs600491 polymorphism on the susceptibility to Alzheimer disease.

Mouse (Murine) 24-Dehydrocholesterol Reductase (DHCR24) interaction partners

  1. When DHCR24 is genetically deleted there is a decreased association of EAAT2 (show SLC1A2 Proteins) with lipid rafts after ischemia.

  2. Data (including data from transgenic mice) suggest that expression of Dhcr24 is down-regulated in brain tissues of mice exhibiting symptoms modeling advanced Huntington's disease.

  3. RE1-silencing transcription factor acts because it is bound in close proximity to SREBP, thus amplifying its ability to upregulate 24-dehydrocholesterol reductase

  4. concluded that TH up-regulates Seladin-1 gene expression at the transcriptional level and LXR-alpha (show NR1H3 Proteins) maintains the gene expression

  5. This is the first demonstration that DHCR24 plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species.

  6. Seladin-1 is shown to be an LPS (show TLR4 Proteins)-responsive gene that negatively regulates the TNF- alpha (show TNF Proteins) production and bone resorption in response to LPS (show TLR4 Proteins).

  7. Seladin-1-dependent cholesterol synthesis is involved in lowering Abeta (show APP Proteins) levels.

  8. cellular cholesterol biosynthesis is critical for the activation and maintenance of the Akt (show AKT1 Proteins)-Bad cell survival cascade in response to growth factors such as insulin (show INS Proteins).

  9. Cholesterol homeostasis in Dhcr24 knockout mice is characterized by strong activation of liver X receptor-targeted genes and by mechanisms compensating for cholesterol depletion.

  10. ablation of DHCR24/seladin-1 prevented apoptosis of primary neurons in a p53 (show TP53 Proteins)-dependent manner

Seladin 1 (DHCR24) Protein Profile

Protein Summary

This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.

Gene names and symbols associated with DHCR24

  • 24-dehydrocholesterol reductase (DHCR24)
  • 24-dehydrocholesterol reductase (dhcr24)
  • 24-dehydrocholesterol reductase (AaeL_AAEL012138)
  • 24-dehydrocholesterol reductase (CpipJ_CPIJ000670)
  • 24-dehydrocholesterol reductase (Dhcr24)
  • 2310076D10Rik protein
  • 5830417J06Rik protein
  • DCE protein
  • MGC82737 protein
  • mKIAA0018 protein
  • Nbla03646 protein
  • seladin-1 protein
  • SELADIN1 protein
  • zgc:101638 protein

Protein level used designations for DHCR24

24-dehydrocholesterol reductase , 3 beta-hydroxysterol delta 24-reductase , 3-beta-hydroxysterol delta-24-reductase , delta(24)-sterol reductase , desmosterol-to-cholesterol enzyme , diminuto/dwarf1 homolog , seladin 1 , selective AD indicator 1 , 3-beta-hydroxysterol delta-24 reductase , seladin-1

GENE ID SPECIES
424661 Gallus gallus
447786 Xenopus laevis
456879 Pan troglodytes
489573 Canis lupus familiaris
494102 Danio rerio
549554 Xenopus (Silurana) tropicalis
5575872 Aedes aegypti
6031429 Culex quinquefasciatus
100546716 Meleagris gallopavo
100584832 Nomascus leucogenys
1718 Homo sapiens
74754 Mus musculus
298298 Rattus norvegicus
533726 Bos taurus
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