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Synthesis and degradation of fructose 2,6-bisphosphate.. Additionally we are shipping PFKFB4 Antibodies (34) and many more products for this protein.
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These findings highlight novel and essential roles of PFKFB4 activity in later stages of neural crest (NC) development that are wired into the NC gene regulatory network.
High PFKFB4 expression is associated with colon and lung cancer.
This work has uncovered a novel function of the enzymes PFKFB3 (show PFKFB3 Proteins) and PFKFB4 in ovarian cancer cells during mitotic arrest
HIF-1alpha (show HIF1A Proteins) transactivates hypoxia-responsive elements (HRE)-D of the promoter region of PFKFB4 in hypoxia condition.
The expression of PFKFB3 (show PFKFB3 Proteins), PFKFB4, NAMPT (show NAMPT Proteins), and TSPAN13 (show TSPAN13 Proteins) is strongly up-regulated in pediatric glioma.
Inhibition of PFKFB4 suppresses glycolysis and proliferation of multiple human cancer cell lines.
PFKFB4 suppresses oxidative stress and p62 (show GTF2H1 Proteins) accumulation, without which autophagy is stimulated likely as a ROS (show ROS1 Proteins) detoxification response.
Data indicate that the PFKFB4 expressed in multiple transformed cells and tumors functions to synthesize F2,6BP.
we found that the glycolytic enzyme PFKFB4 is essential for prostate cancer cell survival by maintaining the balance between the use of glucose for energy generation and the synthesis of antioxidants.
PFKFB4 has an important role in the progression of non-muscle-invasive bladder cancer (
PFKFB4 and HO-2 (show HMOX2 Proteins) are expressed in a coordinated manner to maintain glucose homeostasis.
Synthesis and degradation of fructose 2,6-bisphosphate.
, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4-like
, 6PF-2-K/Fru-2,6-P2ase 4
, 6PF-2-K/Fru-2,6-P2ase testis-type isozyme
, PFK/FBPase 4
, bifunctional enzyme with kinase and biphosphatase activities
, 6PF-2-K/Fru-2,6-P2ASE testis-type isozyme