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ABI3 encodes a member of an adaptor protein family. Additionally we are shipping ABI3 Antibodies (24) and many more products for this protein.
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Result links ABI3 to the pathogenesis and progression of some cancers and suggests that ABI3 or its pathway might have interest as therapeutic target.
Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells.
NESH (Abi-3), like Abi-1 (show ABI1 Proteins) and Abi-2, is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl (show ABL1 Proteins).
The expression of NESH/Abi-3 caused degradation of endogenous Abi-1 (show ABI1 Proteins), which led to the formation of a NESH/Abi-3-based WAVE2 (show WASF2 Proteins) complex.
This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates Rac-dependent actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase.
ABI gene family member 3
, ABI gene family, member 3
, new molecule including SH3
, NESH protein