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ADAMTS15 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Additionally we are shipping ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 15 Kits (22) and ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 15 Proteins (3) and many more products for this protein.
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spiking parvalbumin (show PVALB Antibodies) interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts15 in mice.
Results show that ADAMTS15 and ADAMTS4 (show ADAMTS4 Antibodies) not only exhibit unique cellular expression patterns in the brain but their developmental upregulation by these cell types coincides with critical aspects of neural development
these data suggest a role for ADAMTS15 in a wide range of biological processes that are potentially mediated through the processing of versican (show Vcan Antibodies).
ADAMTS15 is a candidate gene for intracranial aneurysms
ADAMTS-15 has multiple actions on tumor pathophysiology including modulation of cell-extracellular matrix interactions, which likely involve syndecan-4 (show SDC4 Antibodies).
Versican (show Vcan Antibodies) processing by ADAMTS5 (show ADAMTS5 Antibodies) and ADAMTS15 contribute to muscle fiber formation.
ADAMTS-15 but not ADAMTS-1 (show ADAMTS1 Antibodies) expression was downregulated by androgen in LNCaP prostate cancer cells, possibly through androgen response elements associated with the gene
negative effect of TGFbeta1 (show TGFB1 Antibodies) on ADAMTS-1 (show ADAMTS1 Antibodies), -5, -9, and -15 coupled with increases in their inhibitor, TIMP-3 (show TIMP3 Antibodies) may aid the accumulation of versican (show Vcan Antibodies) in the stromal compartment of the prostate in BPH (show GLI3 Antibodies) and prostate cancer
ADAMTS8 (show ADAMTS8 Antibodies) and ADAMTS15 have emerged as novel predictors of survival in patients with breast carcinoma
ADAMTS15 may be target of inactivating mutations in human cancer.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the proteins encoded by ADAMTS1 and ADAMTS8.
A disintegrin and metalloproteinase with thrombospondin motifs 15
, ADAM-TS 15
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 15, preproprotein
, metalloprotease disintegrin 15 with thrombospondin domains
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 15