You are viewing an incomplete version of our website. Please click to reload the website as full version.

ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Proteins (ADAMTS4)

ADAMTS4 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Additionally we are shipping ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Antibodies (136) and ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Kits (41) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat ADAMTS4 ADAMTS4 361332  
ADAMTS4 240913 Q8BNJ2
ADAMTS4 9507 O75173
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human His tag 5 μg Log in to see 5 to 6 Days
$271.43
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$246.96
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 11 to 13 Days
$704.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$889.07
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ADAMTS4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
,

More Proteins for ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) Interaction Partners

Rabbit ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) interaction partners

  1. a single injection of ADAMTS5 (show ADAMTS5 Proteins) siRNA induced the suppression of degradation in rabbit nucleus pulposus tissues

Horse (Equine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) interaction partners

  1. Studies suggest that miR (show MYLIP Proteins)-140 is an important regulator of cartilage development and homeostasis in cord blood-derived mesenchymal stromal cells (eCB-MSCs) that may act, in part, through the regulation of CXCL12 (show CXCL12 Proteins) and ADAMTS-5 (show ADAMTS5 Proteins).

  2. ADAMTS5 (show ADAMTS5 Proteins) is present in degenerative suspensory ligament desmitis as a high molecular weight complex

Cow (Bovine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) interaction partners

  1. ADAMTS4 participates in the regulation of muscle development in cattle.

  2. aggrecanase activity (a) is responsible for early TNFalpha (show TNF Proteins)-dependent aggrecan (show ACAN Proteins) cleavage and GAG release in the meniscus and (b) might be involved in meniscal degeneration.

  3. ADAMTS4 and ADAMTS5 (show ADAMTS5 Proteins) are inhibited by alpha2-macroglobulin (show A2M Proteins)

  4. identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 and ADAMTS-5 (show ADAMTS5 Proteins)

Mouse (Murine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) interaction partners

  1. Results show that ADAMTS15 (show ADAMTS15 Proteins) and ADAMTS4 not only exhibit unique cellular expression patterns in the brain but their developmental upregulation by these cell types coincides with critical aspects of neural development

  2. aggrecan (show ACAN Proteins) and brevican (show BCAN Proteins) proteolysis is compensated in Adamts4-/- or Adamts5 (show ADAMTS5 Proteins)-/- mice by ADAMTS (show ADAMTS1 Proteins) proteoglycanase (show MMP3 Proteins) family members but a threshold of versican (show Vcan Proteins) proteolysis is sensitive to the loss of a single ADAMTS (show ADAMTS1 Proteins) proteoglycanase (show MMP3 Proteins) during spinal cord injury

  3. The serine protease (show F2 Proteins) tissue plasminogen activator (tPA (show PLAT Proteins)) and two matrix metalloproteinases, ADAMTS-4 and ADAMTS-5 (show ADAMTS5 Proteins), were identified as Reelin (show RELN Proteins) cleaving enzymes.

  4. ADAMTS-4 cleaves Reelin (show RELN Proteins) in an isoform-specific manner. Among ADAMTS-4 isoforms, p50 (show LSP1 Proteins) cleaves the N-t site only, while p75 (show NGFR Proteins) cleaves both sites.

  5. Data demonstrate that Adamts1 (show ADAMTS1 Proteins) and Adamts4 play redundant and essential roles in perinatal kidney development.

  6. Drastic down-regulation of Adamts4 observed at both E16 and E18; RT-PCR revealed post-natal reduction in expression (Adamts4, 1/3). Results suggest down-regulation of gene is important factor in normal odontogenesis in dental papillae.

  7. proteolysis of hevin by ADAMTS4 in the mouse cerebellum is important for the normal development of this tissue

  8. ADAMTS1 (show ADAMTS1 Proteins), ADAMTS4, and ADAMTS5 (show ADAMTS5 Proteins) are expressed in patterns that relate to the expression pattern of versican (show Vcan Proteins) in granulosa cells of small follicles, expanded cumulus cell-oocyte complexes, and endothelial cells of the ovary.

  9. ADAMTS-5 (show ADAMTS5 Proteins) is entirely responsible for cleavage in the interglobular domain, but cleavage in the chondroitin sulfate-rich region may be driven by ADAMTS-4

  10. comparison of aggrecan (show ACAN Proteins) loss with aggrecan (show ACAN Proteins) processing in mice with single and double deletions of ADAMTS-4 and -5 activity (Deltacat)

Human ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) interaction partners

  1. progesterone acts via the progesterone receptor (show PGR Proteins) to modulate ADAMTS 1 (show ADAMTS1 Proteins) and 4 levels in ovarian cancer cell lines.

  2. ADAMTS4 may be responsible for the pathogenesis of atherosclerosis. ADAMTS4 serum levels were also higher in diabetic cases. There is an association between ADAMTS4 and TGFb1 (show TGFB1 Proteins) serum levels in the progression of atherosclerosis in coronary artery disease.

  3. Evaluate ADAMTS-4 and ADAMTS-5 (show ADAMTS5 Proteins) immunohistochemical expression in human TMJ discs from patients affected by internal derangement.

  4. These data demonstrate that the antibody is specific to ADAMTS4 and ADAMTS5 (show ADAMTS5 Proteins) and inhibits their aggrecanase activity at molecular and cellular levels.

  5. ADAMTS4 is largely associated with synapses, and is the main brevican (show BCAN Proteins)-processing protease.

  6. ADAMTS-4 is a potential biomarker and an early diagnostic indicator of knee osteoarthritis.

  7. A positive feedback loop involving sSema4D/IL-6 (show IL6 Proteins) and TNFalpha (show TNF Proteins)/ADAMTS-4 may contribute to the pathogenesis of rheumatoid arthritis.

  8. CCN1 (show CCNA2 Proteins) suppresses ADAMTS-4 activity and that CCN1 (show CCNA2 Proteins) overexpression is directly correlated with chondrocyte cloning in osteoarthritis cartilage. The TGFbeta (show TGFB1 Proteins)/CCN1 (show CCNA2 Proteins) axis plays a role in chondrocyte cluster formation through inhibition of ADAMTS-4.

  9. Our results indicate that miR (show MLXIP Proteins)-125b plays an important role in regulating the expression of ADAMTS-4 in human chondrocytes

  10. We conclude that the upregulation of TNF-alpha (show TNF Proteins) and ADAMTS-5 (show ADAMTS5 Proteins), but not ADAMTS-4, may play an important role in degenerative cartilage endplate-induced low back pain.

ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 (ADAMTS4) Protein Profile

Protein Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

Gene names and symbols associated with ADAMTS4

  • ADAM metallopeptidase with thrombospondin type 1 motif, 4 (ADAMTS4)
  • aggrecanase-1 (ADAMTS-4)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 19 (Adamts19)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 19 (ADAMTS19)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 13 (ADAMTS13)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2) (ADAMTS5)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 5 (ADAMTS5)
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 (Adamts4)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 4 (Adamts4)
  • ADAMTS-like 4 (ADAMTSL4)
  • 3830423K05 protein
  • ADAM-TS4 protein
  • ADAMTS-2 protein
  • ADAMTS-4 protein
  • ADAMTS-11 protein
  • ADAMTS4 protein
  • ADAMTS5 protein
  • ADAMTS13 protein
  • ADMP-1 protein
  • DKFZp469J0817 protein
  • mKIAA0688 protein

Protein level used designations for ADAMTS4

ADAM metallopeptidase with thrombospondin type 1 motif, 4 , aggrecanase-1 , A disintegrin and metalloproteinase with thrombospondin motifs 4-like , A disintegrin and metalloproteinase with thrombospondin motifs 19 , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19 , ADAM metallopeptidase with thrombospondin type 1 motif, 19 , ADAM metallopeptidase with thrombospondin type 1 motif, 13 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13 , ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2) , ADAM metallopeptidase with thrombospondin type 1 motif, 5 , ADAM metallopeptidase with thrombospondin type 1 motif, 19-like , aggrecanase-2 , A disintegrin and metalloproteinase with thrombospondin motifs 4 , ADAM-TS 4 , ADAMTS-4 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 , ADAM-TS4 , Aggrecanase , a disintegrin and metallopeptidase with thrombospondin motifs 4 , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 , ADMP-1 , disintegrin and metalloproteinase with thrombospondin motifs 2

GENE ID SPECIES
457453 Pan troglodytes
719927 Macaca mulatta
100008765 Oryctolagus cuniculus
100033914 Equus caballus
100171426 Pongo abelii
100409334 Callithrix jacchus
100482466 Ailuropoda melanoleuca
100606067 Nomascus leucogenys
361332 Rattus norvegicus
415600 Gallus gallus
417152 Gallus gallus
427971 Gallus gallus
462039 Pan troglodytes
473153 Pan troglodytes
473935 Pan troglodytes
487713 Canis lupus familiaris
537961 Bos taurus
705362 Macaca mulatta
707672 Macaca mulatta
100008799 Oryctolagus cuniculus
100066005 Equus caballus
240913 Mus musculus
9507 Homo sapiens
66015 Rattus norvegicus
286806 Bos taurus
488651 Canis lupus familiaris
100712995 Cavia porcellus
101106565 Ovis aries
100514576 Sus scrofa
Selected quality suppliers for ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 4 Proteins (ADAMTS4)
Did you look for something else?