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The protein encoded by ADAMTS7 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Additionally we are shipping ADAMTS7 Kits (26) and ADAMTS7 Proteins (9) and many more products for this protein.
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Therefore, these data provided the in vivo evidence, suggesting that ADAMTS-7 may play an important role in the pathogenesis of inflammatory arthritis.
Mice lacking Adamts7, Ldlr, Apoe had less lesion formation in aortas and aortic roots vs controls and less neointimal formation after femoral wire injury. Adamts7 expression was induced by injury and hyperlipidemia.
Adamts-7 deficiency substantially ameliorated neointima formation in mice at days 14 and 28 after injury. ADAMTS-7 inhibited both endothelial cell proliferation and migration.
ADAMTS-7 and TNF-alpha (show TNF Antibodies) form a positive feedback loop in the regulation of cartilage degradation and osteoarthritis progression.
ADAMTS7B has a domain organization with a total of eight thrombospondin type 1 repeats in its ancillary domain. Of these, seven are arranged in two distinct clusters that are separated by a mucin (show SLC13A2 Antibodies) domain
Findings demonstrate that ADAMTS-7, a direct target of PTHrP (show PTHLH Antibodies) signaling, negatively regulates endochondral bone formation by associating with and inactivating GEP (show GRN Antibodies) chondrogenic growth factor.
During inflammatory conditions, AP-1 (show FOSB Antibodies) and Sp1 (show PSG1 Antibodies) sustained the expression of ADAMTS7, and ADAMTS7 sustained the expression of catabolic genes in nucleus pulposus cells
ADAMTS7 and LPA single nucleotide polymorphisms are related to a 24-h ambulatory systolic-diastolic pressure regression index.
Expression of miR (show MLXIP Antibodies)-26a and miR (show MLXIP Antibodies)-29a was significantly down regulated in leukoplakia and cancer tissues but up regulated in lichen planus tissues. Expression of target genes such as, ADAMTS7, ATP1B1 (show ATP1B1 Antibodies), COL4A2 (show COL4a2 Antibodies), CPEB3 (show CPEB3 Antibodies), CDK6 (show CDK6 Antibodies), DNMT3a (show DNMT3A Antibodies) and PI3KR1 was significantly down regulated in at least two of three disease types with respect to normal tissues.
Our results indicate the presence of ADAMTS-7 in human NP cells and imply its potential role in disc degeneration.
The main contribution of this study is the proposal of a pharmacophore for ADAMTS7.
The significant associations observed between this coding variant in ADAMTS7 and the risk of CAD (show CAD Antibodies) development.
Logistic regression analysis indicated that the association between ADAMTS-7 and heart failure after AMI (show CFD Antibodies) was independent from traditional cardiovascular risk factors and other biomarkers
Data conclude that ADAMTS-7 level appears to be positively associated with expression of TNF-alpha (show TNF Antibodies) and Phospho-NF-kappaB (show NFKB1 Antibodies) P65 (show GORASP1 Antibodies) in cartilage, which may imply its association with cartilage destruction of ONFH.
ADAMTS7 localized to cells having smooth muscle cell markers in human coronary artery disease lesions. Cultured vascular smooth muscle cells had ADAMTS7 at the cytoplasm and cell membrane, where it colocalized with markers of podosomes.
There was a reduction in the amount of cleaved ADAMTS7 prodomain in media conditioned by VSMCs of the G/G genotype.
The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two C-terminal TS motifs.
ADAM metallopeptidase with thrombospondin type 1 motif, 7
, A disintegrin and metalloproteinase with thrombospondin motifs 7
, ADAM-TS 7
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7
, a disintegrin and metalloprotease with thrombospondin motifs-7 preproprotein
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 7