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ADAMTS18 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Additionally we are shipping ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 Antibodies (40) and ADAM Metallopeptidase with thrombospondin Type 1 Motif, 18 Proteins (3) and many more products for this protein.
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Adamts18 deficiency enhances tumorigenesis and intestinal inflammation through elevated Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) and p38MAPK (show MAPK14 ELISA Kits)/ERK1/2 (show MAPK1/3 ELISA Kits) signaling and promotes colon cancer in a mouse model.
these data demonstrate a thrombin (show F2 ELISA Kits) cleavage site and confirm a short form of ADAMTS-18 presents in vivo.
Adamts18 is expressed in the lens and retina in the developing murine eye.
Studies suggest that ADAM metallopeptidase (show ECEL1 ELISA Kits) with thrombospondin type 1 motif, 18 protein (ADAMTS-18) as a promising diagnostic and therapeutic target.
Novel homozygous mutations in ADAMTS18 were identified, consisting of c.1067T>A [p.L356*] in the first proband, c.2159G>C [p.C720S] in the 2 affected brothers
Results suggest that ADAMTS18 plays an essential role in early eye development and that mutations therein cause a distinct eye phenotype that is mainly characterized by microcornea and myopia.
study reveals that mutations in the ADAMTS18 gene can cause a broad phenotypic spectrum of eye disorders and contribute to shed further light on the complexity of retinal diseases
the study identified ADAMTS18 as the only gene carrying a homozygous protein altering mutation.
ADAMTS18 mutations promote growth, migration, and metastasis in melanoma
ADAMTS18 gene methylation in 3 types of cancers was significantly higher than normal tissues. No significant association was found between methylation status & TNM (show ODZ1 ELISA Kits) staging. Epigenetic regulation of ADAMTS18 was associated with carcinogenesis.
comparison of the effects of C-terminal truncation on the GAG-binding properties and aggrecanase (show ADAMTS4 ELISA Kits) activity of ADAMTS-5 (show ADAMTS5 ELISA Kits) relative to three other ADAMTS (show ADAMTS13 ELISA Kits) family members, ADAMTS-9 (show ADAMTS9 ELISA Kits), ADAMTS-16 (show ADAMTS16 ELISA Kits) and ADAMTS-18
Functional epigenetics show ADAMTS18 to be a novel functional tumor suppressor, being frequently inactivated epigenetically in multiple carcinomas.
ADAMTS18 and TGFBR3 (show TGFBR3 ELISA Kits) might underlie BMD (show BEST1 ELISA Kits) determination in the major human ethnic groups.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.
A disintegrin and metalloproteinase with thrombospondin motifs 18
, ADAM-TS 18
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 21
, disintegrin and metalloprotease-like protein
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18