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ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. Additionally we are shipping ARL4A Kits (12) and ARL4A Proteins (9) and many more products for this protein.
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Human Polyclonal ARL4A Primary Antibody for ELISA, WB - ABIN184801
Jacobs, Schürmann, Becker, Böckers, Copeland, Jenkins, Joost: The mouse ADP-ribosylation factor-like 4 gene: two separate promoters direct specific transcription in tissues and testicular germ cell. in The Biochemical journal 1998
Show all 3 references for ABIN184801
Deletion of the ARL4A-interacting region of GCC185 (show GCC2 Antibodies) results in inability to maintain Golgi structure and modulate endosome-to-Golgi transport.
membrane targeting of ELMO via Arl4A promotes cytoskeletal reorganization including membrane ruffling and stress fiber disassembly via an ELMO-DOCK1800-Rac (show AKT1 Antibodies) signaling pathway.
Study shows that three related Arf (show CDKN2A Antibodies)-like GTPases Arl4a, Arl4c (show ARL4C Antibodies), and Arl4d (show ARL4D Antibodies), are able to recruit ARNO (show CYTH2 Antibodies) and other cytohesins to the plasma membrane by binding to their PH domains irrespective of whether they are in the diglycine or triglycine form.
The loss of PTEN (show PTEN Antibodies) was shown to lead to increased levels of ARF4L (show ARL4D Antibodies) protein but no change in transcript levels. The ARF4L (show ARL4D Antibodies) transcript preferentially localized to the polysomal compartment after PTEN (show PTEN Antibodies) loss in glioma.
Reduced sperm count and normal fertility in male mice with targeted disruption of the ADP-ribosylation factor-like 4 (Arl4) gene.
This gene was a target of WNT (show WNT2 Antibodies) signlaing in the dorsal somite.
ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene.
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