ALX Homeobox 4 Proteins (ALX4)

ALX4 encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Additionally we are shipping ALX4 Antibodies (58) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALX4 60529 Q9H161
Rat ALX4 ALX4 296511  
ALX4 11695 O35137
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Top ALX4 Proteins at

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days

ALX4 Proteins by Origin and Source

Origin Expressed in Conjugate

Mouse (Murine)

More Proteins for ALX Homeobox 4 (ALX4) Interaction Partners

Human ALX Homeobox 4 (ALX4) interaction partners

  1. overexpression of ALX4 inhibited the proliferation, invasion, and epithelial-mesenchymal transition (EMT (show ITK Proteins)) in HCC (show FAM126A Proteins) cells. ALX4 had an inhibitory effect on the sonic hedgehog (Shh (show SHH Proteins)) signaling pathway.

  2. mother of Case 2 also had a mutation in the ALX4 gene, but no enlarged parietal foramina

  3. Our results show that HOXB13 (show HOXB13 Proteins)/SLUG (show SNAI2 Proteins) and ALX4/SLUG (show SNAI2 Proteins) axes are novel pathways that promote EMT (show ITK Proteins) and invasion of ovarian cancer cells.

  4. High-quality solution NMR structures of three homeodomains from human proteins ALX4, ZHX1 and CASP8AP2 were solved.

  5. We suggest that all ALX4 heterozygote carriers be examined in detail for possible changes in nasal configuration, to establish a detailed genotype-phenotype correlation, leading the way to more comprehensive genetic counseling.

  6. Epigenetic silencing of Aristaless-like homeobox-4 is associated with lung cancer.

  7. study describes 2 related individuals with a heterozygous mutation in ALX4 presenting a distinct phenotype of frontonasal dysplasia; suggest that the loss of the ALX4 OAR domain with the maintenance of the homeodomain impairs the function of the normal allele in a dominant-negative effect

  8. ALX4 variants may have an impact on the genetic etiology of nonsyndromic craniosynostosis.

  9. Exclusion of mutations in ALX4 gene in patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies

  10. Downregulation of HoxB2 (show HOXB2 Proteins), HoxB4 (show HOXB4 Proteins) and Alx4 expression during the narrow window of early embryogenesis may cause omphalocele in the Cd chick model by interfering with molecular signaling required for proper VBW formation.

Cow (Bovine) ALX Homeobox 4 (ALX4) interaction partners

Mouse (Murine) ALX Homeobox 4 (ALX4) interaction partners

  1. novel allele of Alx4 results in reduced Fgf10 (show FGF10 Proteins) expression and failure of eyelid fusion in mice

  2. Alx4 genetically interacts with and Shh (show SHH Proteins) and Gli3 (show GLI3 Proteins) during genital tubercle formation.

  3. A mutagenesis study characterizes a polydactylous phenotype that is caused by a nonsense mutation in the Alx4 gene.

  4. Progression of calvarial bone development requires Foxc1 (show FOXC1 Proteins) regulation of Msx2 and Alx4.

  5. the loss of the severe preaxial polydactyly characteristic of Gli3 (show GLI3 Proteins)-/- limbs in double mutant embryos establishes that this type of polydactyly requires Alx4 function.

  6. Function and regulation of Alx4 in limb development entail complex genetic interactions with Gli3 (show GLI3 Proteins) and Shh (show SHH Proteins).

  7. Alx4, is required for normal branching morphogenesis of the ductal epithelia during pubescent mammary gland development.

ALX4 Protein Profile

Protein Summary

This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2)\; an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism\; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS)\; a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart.

Gene names and symbols associated with ALX Homeobox 4 Proteins (ALX4)

  • aristaless-like homeobox 4b (alx4b)
  • aristaless-like homeobox 4a (alx4a)
  • ALX homeobox 4 (ALX4)
  • ALX homeobox 4 (Alx4)
  • aristaless-like homeobox 4 (Alx4)
  • alx4 protein
  • FND2 protein
  • im:7142878 protein
  • lst protein
  • zgc:162606 protein

Protein level used designations for ALX Homeobox 4 Proteins (ALX4)

aristaless-like homeobox 4 , homeobox protein aristaless-like 4 , homeodomain transcription factor ALX4 , aristaless 4 , ALX-4 , Aristaless-like 4 , Strong's luxoid

497424 Danio rerio
100006399 Danio rerio
60529 Homo sapiens
609979 Canis lupus familiaris
296511 Rattus norvegicus
594846 Bos taurus
373976 Gallus gallus
11695 Mus musculus
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