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ARID2 is a subunit of the PBAF chromatin-remodeling complex (see BAF180\; MIM 606083), which facilitates ligand-dependent transcriptional activation by nuclear receptors (Yan et al., 2005 [PubMed 15985610]).[supplied by OMIM, Mar 2008]..
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ARID2 knockout could contribute to disruption of DNA repair process.
study identifies mutations in the ARID2 gene as a novel and rare cause for a CSS (show CMAS Antibodies)-like phenotype and enlarges the list of CSS (show CMAS Antibodies)-like genes
Baf200 and Rad51 (show RAD51 Antibodies) are present in the same complex and that this interaction is mediated by C-terminal sequences in both proteins.
Results show that ARID2 is a direct target of miR155 in human hepatocellular carcinoma (HCC (show FAM126A Antibodies)). Alterations of ARID2 expression abrogated the effects of miR155 on HCC (show FAM126A Antibodies) cell proliferation, cell cycle and apoptosis.
This is the first report of mutations in ARID2 associated with developmental delay and intellectual disabilities .
Arid2 role in genome-wide transcriptional regulation by SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) complexes.
The subsequent validation study on 68 LCBs identified recurrent mutations in TERT promoter, chromatin regulators (BAP1, PBRM1 and ARID2), a synapse organization gene (PCLO), IDH genes and KRAS.
loss of ARID2 protein expression may be associated with recurrence of hepatocellular carcinoma
Mutations in ARID2 gene is associated with microsatellite unstable colorectal cancer.
Recurrent inactivating mutations of ARID2 is associated with non-small cell lung carcinoma.
a critical role for ARID2-containing complexes in promoting osteoblast differentiation and supports a view that the PBAF subset of SWI (show SMARCA1 Antibodies)/SNF (show SNRPA Antibodies) contributes importantly to maintaining cellular identity and activating tissue-specific gene expression.
zipzap may serve as a transcription co-activator for the regulation of cardiac gene expression
ARID2 is a subunit of the PBAF chromatin-remodeling complex (see BAF180\; MIM 606083), which facilitates ligand-dependent transcriptional activation by nuclear receptors (Yan et al., 2005
AT rich interactive domain 2 (ARID, RFX-like)
, AT-rich interactive domain-containing protein 2
, AT-rich interactive domain-containing protein 2-like
, ARID domain-containing protein 2
, BRG1-associated factor 200
, zinc finger protein with activation potential
, AT rich interactive domain 2 (Arid-rfx like)