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The protein encoded by ATG16L1 is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Additionally we are shipping ATG16L1 Proteins (8) and ATG16L1 Kits (5) and many more products for this protein.
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Human Polyclonal ATG16L1 Primary Antibody for IF, IHC (p) - ABIN388542
Baehrecke: Autophagy: dual roles in life and death? in Nature reviews. Molecular cell biology 2005
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Human Polyclonal ATG16L1 Primary Antibody for EIA, IHC (p) - ABIN1449612
Nomura, Uzawa, Yamano, Fushimi, Ishigami, Kouzu, Koike, Siiba, Bukawa, Yokoe, Kubosawa, Tanzawa: Overexpression and altered subcellular localization of autophagy-related 16-like 1 in human oral squamous-cell carcinoma: correlation with lymphovascular invasion and lymph-node metastasis. in Human pathology 2008
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Human Polyclonal ATG16L1 Primary Antibody for EIA, IHC (p) - ABIN1449636
Lum, DeBerardinis, Thompson: Autophagy in metazoans: cell survival in the land of plenty. in Nature reviews. Molecular cell biology 2005
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Human Polyclonal ATG16L1 Primary Antibody for IHC (p), WB - ABIN388543
Greenberg: Degrade or die: a dual function for autophagy in the plant immune response. in Developmental cell 2005
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Cow (Bovine) Polyclonal ATG16L1 Primary Antibody for EM, IHC - ABIN258803
Plantinga, Crisan, Oosting, van de Veerdonk, de Jong, Philpott, van der Meer, Girardin, Joosten, Netea: Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2. in Gut 2011
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Human Polyclonal ATG16L1 Primary Antibody for EIA, IF - ABIN497988
Kamada, Funakoshi, Shintani, Nagano, Ohsumi, Ohsumi: Tor-mediated induction of autophagy via an Apg1 protein kinase complex. in The Journal of cell biology 2000
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Mouse (Murine) Polyclonal ATG16L1 Primary Antibody for ELISA, WB - ABIN451668
Rioux, Xavier, Taylor, Silverberg, Goyette, Huett, Green, Kuballa, Barmada, Datta, Shugart, Griffiths, Targan, Ippoliti, Bernard, Mei, Nicolae, Regueiro, Schumm, Steinhart, Rotter, Duerr, Cho, Daly et al.: Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. ... in Nature genetics 2007
Human Polyclonal ATG16L1 Primary Antibody for DB - ABIN2839681
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003
we focus on the contributions of the plasma membrane to autophagosome biogenesis governed by ATG16L1 and ATG9A (show ATG9A Antibodies) trafficking, and summarize the physiological and pathological implications of this macroautophagy route, from development and stem cell fate to neurodegeneration and cancer.
ATG16L1 T300A Polymorphism is Correlated with Gastric Cancer Susceptibility.
Induction of Anti-TNF (show TNF Antibodies) induced macrophages is impaired in donors carrying the T300A risk allele for the ATG16L1 suggesting that an intact autophagy pathway may be important for an optimal response to anti-TNF (show TNF Antibodies) therapy in inflammatory bowel disease.
The Egr-1 (show EGR1 Antibodies) and Atg16L1 genes' polymorphisms were significant risk factors for susceptibility to chronic obstructive pulmonary disease (COPD (show ARCN1 Antibodies)) . These results demonstrate that autophagy regulator genetic mutations are associated with COPD (show ARCN1 Antibodies) in male smokers.
Subjects homozygous for the autophagy-related 16-like protein (ATG16L1) CD-associated gene variant (rs2241880), had low SHIP mRNA expression and activity.
The Thr300Ala variant in ATG16L1 is associated with improved survival in human colorectal cancer and enhanced production of type I interferon (show IFNA Antibodies).
ATG16L1 as a bona fide physiological CSNK2 and PPP1 substrate, which reveals a novel molecular link from CSNK2 to activation of the autophagy-specific ATG12 (show ATG12 Antibodies)-ATG5 (show ATG5 Antibodies)-ATG16L1 complex and autophagy induction
Knockdown of Atg16L1, a crucial autophagy gene, leads to developmental retention of early-stage cells in various tissues where the differentiation of stem cells is retarded.
Antibacterial autophagy is impaired in CLEC12A (show CLEC12A Antibodies)-deficient cells, and this effect is exacerbated in the presence of the ATG16L1( *)300A risk allele.
ATG16L1 may be used as a biomarker for selecting oral squamous cell carcinoma patients with a more aggressive phenotype.
Selective deletion of Atg16l1 in T cells in mice resulted in spontaneous intestinal inflammation that was characterized by aberrant type 2 responses to dietary and microbiota antigens, and by a loss of Foxp3 (show FOXP3 Antibodies)(+) Treg cells.
Arg-24 of Atg16L1 is crucial for its interaction with Atg5 (show ATG5 Antibodies) which has implications in the binding of the dimeric complex to Rab33B (show RAB33B Antibodies)
inhibition of IL-1beta (show IL1B Antibodies) signaling abrogates the ATG16L1-dependent protection from Urinary tract infections
A hypomorphic mutation in Atg16L1, a crucial autophagy gene, leads to developmental retention of early-stage cells in various tissues where the differentiation of stem cells is retarded.
findings suggest that the regulatory axis of HIF-1alpha (show HIF1A Antibodies)-miRNA-20a-Atg16l1 might be a critical mechanism for hypoxia-induced osteoclast differentiation
Atg16L1 deficiency leads to an exacerbated graft-versus-host disease in a mouse model of allogeneic hematopoietic stem cell transplantation.
nucleotide-binding oligomerization domain containing 2 (show NOD2 Antibodies) deficiency did not reverse the ATG16L1-deficiency-induced protection from urinary tract infections
Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.
Data indicate that human ATG16L1 and mouse autophagy components Atg7 (show ATG7 Antibodies) and Atg16L1 participate in the IFN-gamma-induced (show SAMHD1 Antibodies) recruitment of the immunity-related GTPases to the intracellular pathogen.
An Atg16L1 deficiency alters the intestinal environment to mediate an enhanced immune response that is dependent on monocytic cells.
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.
ATG16 autophagy related 16-like 1 (S. cerevisiae)
, APG16 autophagy 16-like
, autophagy-related protein 16
, APG16-like 1
, autophagy-related 16-like
, ATG16 autophagy related 16-like 1
, autophagy-related protein 16-1-like
, autophagy-related protein 16-1
, APG16L beta
, WD repeat domain 30
, Atg16L1 gamma
, autophagy-related 16-like 1 gamma
, autophagy-related 16-like 1