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ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 Proteins (ABCA1)

The membrane-associated protein encoded by ABCA1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCA1 Antibodies (120) and ABCA1 Kits (42) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ABCA1 19 O95477
ABCA1 11303 P41233
Rat ABCA1 ABCA1 313210  
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Top ABCA1 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$827.20
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$756.80
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$999.22
Details

ABCA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, ,
Mouse (Murine)

More Proteins for ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) Interaction Partners

Cow (Bovine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) interaction partners

  1. our results highlight the importance of the LXR (show NR1H3 Proteins)/ABCA1 system in brain pericytes and suggest a new role for these cells in brain cholesterol homeostasis.

  2. The expression and distribution of the bovine ABCA1 transporter using quantitative PCR and the sequencing of the entire ABCA1 coding region, including the proximal promoter region, are reported.

  3. Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI (show SCARB1 Proteins) or ABCG1 (show ABCG1 Proteins) but not ABCA1.

Rabbit ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) interaction partners

  1. CSL112 elevation of ABCA1-dependent efflux may target atherosclerotic plaque for cholesterol removal.

Rhesus Monkey ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) interaction partners

  1. These results indicate that simian immunodeficiency virus infection is a significant contributor to primary dyslipidemia, likely through the ability of Nef to suppress ABCA1-dependent reverse cholesterol transport.

Human ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) interaction partners

  1. This work shows that substantial amounts of precursor sterols are transported to a certain PM domain and are removed by the ABCA1-dependent pathway.

  2. Our results suggest that ABCA1 polymorphisms influence plasma lipid variability and coronary heart disease risk

  3. this study aimed to investigate the relationship between ABCA1 polymorphism and apoA-I (show APOA1 Proteins) and HDL (show HSD11B1 Proteins)-C in an attempt to elucidate its correlation with abdominal aortic aneurysm occurrence.

  4. Quercetin increased cholesterol efflux from macrophages through upregulating the expressions of PPARgamma (show PPARG Proteins) and ABCA1.

  5. miR (show MLXIP Proteins)-28-5p participates in atherosclerosis via ERK2 (show MAPK1 Proteins)-mediated upregulation of the ABCA1 pathway.

  6. ABCA1 gene polymorphisms may be associated with low HDL (show HSD11B1 Proteins)-C disease; the low HDL (show HSD11B1 Proteins)-C disease might partly result from interactions between ABCA1 gene polymorphisms and obesity.

  7. The present meta-analysis indicated that the T allelic in rs1883025 variant was significantly associated with the risk of developing AMD (show AMD1 Proteins), particularly at the early stage.

  8. The present study shows that there is no significant difference in the genotypic and allelic frequencies of ABCA1 rs2230806, rs3890182 and rs1800976 polymorphisms between a normal weight group and an overweight/obese group.

  9. A loss-of-function mutation in ABCA1, present in 1:500 individuals, was associated with low plasma levels of apoE (show APOE Proteins) and with high risk of AD and cerebrovascular disease in the general population.

  10. PGG enhances expression of SR-BI and ABCA1 in J774 and THP-1 macrophages

Mouse (Murine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) interaction partners

  1. These studies point to an important role for hematopoietic ABCA1 in modulating a feed-forward mechanism in obesity such that inflamed tissue macrophages stimulate the production of more monocytes, leading to an exacerbation of inflammation and associated disease processes.

  2. These findings may be clinically relevant because HDL's APOE (show APOE Proteins) content associates with CVD risk and ABCA1 deficiency promotes unregulated cholesterol accumulation in human macrophages.

  3. Short-term modulation of miR (show MLXIP Proteins)-27b expression in wild-type mice regulates hepatic LDLR (show LDLR Proteins) and ABCA1 expression but does not influence plasma and hepatic lipid levels.

  4. LXR (show NR1H3 Proteins) activation reduces the growth of xenograft tumour of human oral squamous cell carcinoma cells in mice accompanied by the upregulation of ABCA1 expression and the decline of cholesterol levels in the tumour.

  5. PGG enhances expression of SR-BI and ABCA1 in J774 and THP-1 macrophages

  6. ABCA1(-/-) macrophages deposited much less extracellular cholesterol than wild-type macrophages. These findings demonstrate a novel function of ABCA1 in contributing to macrophage export of cholesterol into the extracellular matrix.

  7. Our data suggest that GLP-1 (show GCG Proteins)-based therapy modulate ABCA1/ABCG1 (show ABCG1 Proteins) expression in adipocytes potentially through an LXR-alpha (show NR1H3 Proteins) mediated process.

  8. The authors identify the putative lipid transporter Abca1 as a critical mediator of LXR's anti-inflammatory effects.

  9. SLP-2 is an ABCA1-dependent regulator of raft composition and of the innate immune response.

  10. identifies ABCA1 as a key macromolecule facilitating bidirectional sterol movement at the PM and shows that ABCA1 controls retrograde sterol transport by modulating a certain clathrin-independent endocytic process

Pig (Porcine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) interaction partners

  1. ABCA1 promoter variants affect transcription activity and plasma HDL (show HSD11B1 Proteins) level in pigs

  2. ABCA1 was up-regulated in monocytes of hypercholesterolemic pigs via oxidized-LDL and prior to development coronary atherosclerosis.

  3. Both region-specific and ubiquitous (ABCA1) phenotype changes were identified as early prelesional responses of the endothelium to hypercholesterolemia

ABCA1 Protein Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.

Gene names and symbols associated with ABCA1

  • ATP-binding cassette, sub-family A (ABC1), member 1 (ABCA1)
  • ATP-binding cassette, sub-family A (ABC1), member 1 (abca1)
  • ATP-binding cassette, sub-family A (ABC1), member 1 (Abca1)
  • ATP-binding cassette, subfamily A (ABC1), member 1 (Abca1)
  • ABC-1 protein
  • Abc1 protein
  • ABCA1 protein
  • CERP protein
  • HDLDT1 protein
  • TGD protein

Protein level used designations for ABCA1

ATP-binding cassette, sub-family A member 1 , ATP-binding cassette transporter 1 , Cholesterol efflux regulatory protein , ATP-binding cassette sub-family A member 1 , ATP-binding cassette transporter , ATP-binding cassette, sub-family A (ABC1), member 1 , ATP-binding cassette, sub-family A member 1-like , ATP-binding cassette sub-family A member 1-like , ATP-binding cassette transporter A1 , cholesterol efflux regulatory protein , membrane-bound , ATP-binding cassette 1

GENE ID SPECIES
464630 Pan troglodytes
535379 Bos taurus
100013781 Monodelphis domestica
100356765 Oryctolagus cuniculus
100441342 Pongo abelii
100483394 Ailuropoda melanoleuca
100491942 Xenopus (Silurana) tropicalis
716107 Macaca mulatta
100557081 Anolis carolinensis
373945 Gallus gallus
19 Homo sapiens
11303 Mus musculus
481651 Canis lupus familiaris
100152112 Sus scrofa
313210 Rattus norvegicus
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