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ATP-Binding Cassette, Sub-Family G (WHITE), Member 5 Proteins (ABCG5)

The protein encoded by ABCG5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ABCG5 Antibodies (34) and ABCG5 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ABCG5 64240 Q9H222
ABCG5 27409 Q99PE8
Rat ABCG5 ABCG5 114628 Q99PE7
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Top ABCG5 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details

ABCG5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine) ,
,

More Proteins for ATP-Binding Cassette, Sub-Family G (WHITE), Member 5 (ABCG5) Interaction Partners

Human ATP-Binding Cassette, Sub-Family G (WHITE), Member 5 (ABCG5) interaction partners

  1. Genetic polymorphism within the ABCG5 gene is a risk factor for diabetes.

  2. crystallization in lipid bilayers to determine the X-ray structure of human G5G8 in a nucleotide-free state at 3.9 A resolution, generating the first atomic model of an ABC (show ABCB6 Proteins) sterol transporter

  3. ATP-binding cassette (ABC (show ABCB6 Proteins)) transporters G5 (ABCG5) and G8 (ABCG8 (show ABCG8 Proteins)) form an obligate heterodimer that limits intestinal absorption and facilitates biliary secretion of cholesterol and phytosterols.

  4. ABCG5/8 variants are associated with susceptibility to coronary heart disease.

  5. Sitosterolemia is caused by a genetic defect of sterolins (ABCG5/ABCG8 (show ABCG8 Proteins)) mapped to the STSL locus. Polymorphic variations in STSL have been linked to lipid levels and gallstone disease

  6. HRD1 (show SYVN1 Proteins) and RMA1 may therefore be negative regulators of disease-associated transporter ABCG5/ABCG8 (show ABCG8 Proteins).

  7. No association of T400K and Y54C polymorphism with hepatic ABCG8 (show ABCG8 Proteins)/G5 mRNA expression.

  8. MI and gallstones, 2 seemingly unrelated diseases, are intrinsically linked via the function of the ABCG5/8 cholesterol transporter.

  9. A novel mutation of ABCG5 gene in a Turkish boy with phytosterolemia presenting with macrotrombocytopenia and stomatocytosis.

  10. The evolutionary conserved region of ABCG5 were found to be responsive to the Liver-X-Receptor.

Cow (Bovine) ATP-Binding Cassette, Sub-Family G (WHITE), Member 5 (ABCG5) interaction partners

  1. high expression levels of both ATP-binding cassette sub-family G member 5 and 8 (ABCG5 and ABCG8 (show ABCG8 Proteins)) were present in bovine liver and digestive tract samples, and in the mammary gland

Mouse (Murine) ATP-Binding Cassette, Sub-Family G (WHITE), Member 5 (ABCG5) interaction partners

  1. ABCG5/G8 mediate mass biliary cholesterol secretion but not from a reverse cholesterol transport-relevant pool.

  2. AdGRP78 reduced expression of lipogenic genes and plasma triglycerides in the db/db (show LEPR Proteins) strain. Both G5 and G8 protein levels increased as did total biliary cholesterol

  3. The data demonstrate that Abcg5/Abcg8 (show ABCG8 Proteins) deficiency reduces the uptake and secretion of both dietary triacylglycerols and cholesterol by the intestine, suggesting a novel role for the sterol transporter in the formation and secretion of chylomicrons.

  4. Sitosterolemia is caused by a genetic defect of sterolins (ABCG5/ABCG8 (show ABCG8 Proteins)) mapped to the STSL (show ABCG8 Proteins) locus. Polymorphic variations in STSL (show ABCG8 Proteins) have been linked to lipid levels and gallstone disease

  5. The absence of an ABCG5/ABCG8 (show ABCG8 Proteins) expression.

  6. Mice with deficient Abcg2 have features of inflammatory DCM and that the reversibility of myocardial T cell infiltration provides a novel model for investigating the progression of myocardial fibrosis.

  7. biliary cholesterol mass secretion under maximal bile salt-stimulated conditions is fully dependent on ABCG5/G8

  8. This study is the first to report such toxic effects of phytosterol accumulation in ABCG5/G8 knockout mice.

  9. The ability of triiodothyronine to stimulate the secretion of cholesterol into bile is largely mediated by the ABCG5/G8 complex.

  10. handling of sterols by the intestine involves both G5G8 and ACAT2 but that an additional factor (possibly Niemann-Pick C1-like 1) may be key in determining absorption efficiency

ABCG5 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia.

Gene names and symbols associated with ABCG5

  • ATP-binding cassette, sub-family G (WHITE), member 5 (ABCG5)
  • ATP-binding cassette, sub-family G (WHITE), member 5 (abcg5)
  • ABC transporter G family protein (abcG5)
  • ATP-binding cassette, sub-family G (WHITE), member 5 (Abcg5)
  • ATP-binding cassette, subfamily G (WHITE), member 5 (Abcg5)
  • AW112016 protein
  • cmp protein
  • DDBDRAFT_0205617 protein
  • DDBDRAFT_0215344 protein
  • DDB_0205617 protein
  • DDB_0215344 protein
  • sterolin-1 protein
  • STSL protein
  • trac protein

Protein level used designations for ABCG5

ATP-binding cassette, sub-family G (WHITE), member 5 (sterolin 1) , ATP-binding cassette sub-family G member 5 , sterolin 1 , ATP-binding cassette transporter , ATP-binding cassette, sub-family G (WHITE), member 5 , ATP-binding cassette sub-family G member 5-like , ATP-binding cassette, subfamily G, member 5 , sterolin-1 , ATP-binding cassette sub-family G (WHITE) member 5 (sterolin 1)

GENE ID SPECIES
100069091 Equus caballus
421401 Gallus gallus
557317 Danio rerio
8623096 Dictyostelium discoideum AX4
100033373 Monodelphis domestica
100145776 Xenopus (Silurana) tropicalis
100350810 Oryctolagus cuniculus
100402892 Callithrix jacchus
100445398 Pongo abelii
100475530 Ailuropoda melanoleuca
100547157 Meleagris gallopavo
100553588 Anolis carolinensis
100601255 Nomascus leucogenys
64240 Homo sapiens
481354 Canis lupus familiaris
100049660 Sus scrofa
515536 Bos taurus
27409 Mus musculus
114628 Rattus norvegicus
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