ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Proteins (ABCB1B)

The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Antibodies (31) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ABCB1B 5243 P08183
ABCB1B 18669 P06795
Rat ABCB1B ABCB1B 24646  
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Top ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Proteins at antibodies-online.com

Showing 4 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 70 to 75 Days
$9,050.32
Details
Yeast REACT_Entamoeba histolytica His tag   50 μg Log in to see 8 to 11 Days
$341.00
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HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 11 Days
$341.00
Details

ABCB1B Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine) ,
,

More Proteins for ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) Interaction Partners

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) interaction partners

  1. A subset of virus-specific CD161 (show KLRB1 Proteins)(+) T cells selectively express the multidrug transporter MDR1 and are resistant to chemotherapy in acute myeloid leukemia (show BCL11A Proteins).

  2. Primary CD4 (show CD4 Proteins)+P-gphigh T cells eliminate intracellular raltegravir more readily than P-gplow cells and HIV-1 viraemia correlates with P-gp (show ABCB4 Proteins) overall activity; specific CD4 (show CD4 Proteins)+P-gphigh T cell subsets could facilitate the persistence of viral replication in vivo and ultimately promote the appearance of drug resistance

  3. We observed an association between ABCB1 (show ABCB1 Proteins) 3435 T/T and lower grade of toxicities (p=0.05) in patients receiving taxanes for breast cancer. No other associations were found for CYP (show PPIG Proteins) 3A4 *1B, 3A5*3 and ABCB1 (show ABCB1 Proteins) C1236T.

  4. that residual SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) complexes lacking SMARCB1 (show SMARCB1 Proteins) are vital determinants of drug sensitivity, not just to TOP2A (show TOP2A Proteins)-targeted agents, but to the much broader range of cancer drugs effluxed by ABCB1 (show ABCB1 Proteins).

  5. Patients with active rheumatoid arthritis have an increased function of ABCB1 and ABCG2, and disease activity is the main determinant of this phenomena.

  6. the induction of P-gp (show ABCB4 Proteins) expression is causally associated with the expression of nestin (show NES Proteins) in leukemia cells

  7. High MDR1 expression is associated with Cisplatin Resistance in Gastric Cancer.

  8. overexpression is a key Initiator of resistance to tyrosine kinase (show TXK Proteins) inhibitors in chronic myeloid leukemia (show BCL11A Proteins) cell lines

  9. The results indicate that human BCRP and not human P-gp (show ABCB4 Proteins) is involved in benzylpenicillin transport.

  10. Study suggests thatSNPs of 1236C > T contributed to an individual variation in anesthetic effects that follow the pediatric tonsillectomy, and also it was figured out that the patients with the MDR1 1236C > T CC genotype displayed superior anesthetic effects compared to those patients who possessed the CT + TT genotype

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) interaction partners

  1. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity

  2. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

  3. Chrysosplenetin inhibited P-gp (show ABCB4 Proteins) activity and reverse the up-regulated P-gp (show ABCB4 Proteins) and MDR1 (show ABCB4 Proteins) levels induced by artemisinin.

  4. Tamsulosin and tolterodine with P-gp (show ABCB4 Proteins) gene expression and activity in an enantiomer-specific way.

  5. Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.

  6. Data show that human transgenic mutant huntingtin (show HTT Proteins) (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1 (show ABCB4 Proteins)) which suggests that MDR1 (show ABCB4 Proteins) might be a potential therapeutic target for Huntington's disease.

  7. In vitro and in vivo downregulation of the ATP binding cassette transporter (show ABCC3 Proteins) B1 by the HMG-CoA reductase (show HMGCR Proteins) inhibitor simvastatin

  8. Efficient chemoprotection of CDD (show CDA Proteins) and MDR1 (show ABCB4 Proteins) transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara (show FOXC1 Proteins)-C and anthracycline application

  9. These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1 (show ABCB1 Proteins)-1Delta mutant mice following exposure to various P-gp (show ABCB4 Proteins) substrates.

  10. Data indicate that the brain penetration of ABT-888 in both Abcb1a/1b-/- and Abcb1a/1b-/-;Abcg2-/- mice was significantly higher than in wild-type mice.

ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) Protein Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

Gene names and symbols associated with ABCB1B

  • ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1)
  • ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b)
  • ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b)
  • ABC20 protein
  • Abcb1 protein
  • CD243 protein
  • CLCS protein
  • GP170 protein
  • mdr protein
  • Mdr1 protein
  • Mdr1b protein
  • P-GP protein
  • Pgy-1 protein
  • Pgy1 protein

Protein level used designations for ABCB1B

P-glycoprotein 1 , colchicin sensitivity , doxorubicin resistance , multidrug resistance protein 1 , ATP-binding cassette sub-family B member 1 , P glycoprotein 1 , multidrug resistance protein 1B , ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1) , ATP-binding cassette, sub-family B (MDR/TAP), member 1B , ATP-binding cassette, subfamily B, member 1B , P-glycoprotein/multidrug resistance 1

GENE ID SPECIES
5243 Homo sapiens
18669 Mus musculus
24646 Rattus norvegicus
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