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The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Antibodies (31) and many more products for this protein.
Showing 4 out of 11 products:
Our data suggest that the C1236T and G2677A/T SNPs in the MDR1 gene are associated with Crohn's disease and the C1236T risk allele with a more severe course of disease in Algerian pediatric patients.
ATPase measurements imply that DCV and Ho are similarly handled by ABCB1, whereas ABCG2 seems to transport DVC more effectively. In addition, we have developed an image-based high content microscopy screening method for simultaneous in situ measurement of the cellular activity and expression of the ABCG2 multidrug transporter
These results show that multidrug resistant leukemia cell microparticle regulation of ABCC1 (show ABCC1 Proteins) in recipient cells is governed by the transfer of both miR (show MLXIP Proteins)-326 and ABCB1 (show ABCB1 Proteins) from donor cells
he modulatory effect of acacetin-doxorubicin combination on doxorubicin influx and efflux was mediated through downregulation of MDR1 treansporter in non-small-cell lung carcinoma (NSCLC) cells.
An additional action of osimertinib that directly inhibits the function of ABCB1 (show ABCB1 Proteins).
ABCB1 polymorphisms may contribute to the blood pressure variation in Han Chinese population and the effect may be specific in females
SMS (show SMS Proteins) regulates the expression and function of drug transporters P-gp (show ABCB4 Proteins) and MRP2 (show ABCC2 Proteins).
BZML is a novel colchicine binding site inhibitor and overcomes multi-drug resistance in A549/Taxol cells by inhibiting P-gp (show ABCB4 Proteins) function and inducing mitotic catastrophe.
We have noted that the implication of C3435T variant on the risk of breast cancer was ethnicity-dependent. However, there is no evidence that ABCB1 (show ABCB1 Proteins) C3435T polymorphism could play a role in susceptibility to breast cancer in Morocco.
no significant clinical relevance between Pgp expression and osteosarcoma survival
Loss of ABCB1 (show ABCB1 Proteins) expression is associated with neonatal hyperbilirubinemia.
the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity
Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.
Chrysosplenetin inhibited P-gp (show ABCB4 Proteins) activity and reverse the up-regulated P-gp (show ABCB4 Proteins) and MDR1 (show ABCB4 Proteins) levels induced by artemisinin.
Tamsulosin and tolterodine with P-gp (show ABCB4 Proteins) gene expression and activity in an enantiomer-specific way.
Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.
Data show that human transgenic mutant huntingtin (show HTT Proteins) (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1 (show ABCB4 Proteins)) which suggests that MDR1 (show ABCB4 Proteins) might be a potential therapeutic target for Huntington's disease.
In vitro and in vivo downregulation of the ATP binding cassette transporter (show ABCC3 Proteins) B1 by the HMG-CoA reductase (show HMGCR Proteins) inhibitor simvastatin
Efficient chemoprotection of CDD (show CDA Proteins) and MDR1 (show ABCB4 Proteins) transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara (show FOXC1 Proteins)-C and anthracycline application
These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1 (show ABCB1 Proteins)-1Delta mutant mice following exposure to various P-gp (show ABCB4 Proteins) substrates.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B
, ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1B
, ATP-binding cassette, subfamily B, member 1B
, P-glycoprotein/multidrug resistance 1