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The membrane-associated protein encoded by ABCB8 is a member of the superfamily of ATP-binding cassette (ABC) transporters. Additionally we are shipping ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 8 Proteins (5) and many more products for this protein.
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Human Polyclonal ABCB8 Primary Antibody for ELISA - ABIN449694
Hogue, Liu, Ling: Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein. in Journal of molecular biology 1999
ABCB8 confers resistance through the protection of mitochondrial DNA from doxorubicin-induced DNA damage in a melanoma cell line.
mutations in ABCB8 and ABCB10 (show ABCB10 Antibodies) is not associated with acute myeloid leukemia (show BCL11A Antibodies).
These results indicate that ABCB8 is essential for normal cardiac function, maintenance of mitochondrial iron homeostasis and maturation of cytosolic Fe/S proteins.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined\; however, it may involve the compartmentalization and transport of heme, as well as peptides, from the mitochondria to the nucleus and cytosol. This protein may also play a role in the transport of phospholipids into mitochondrial membranes.
ATP-binding cassette, sub-family B (MDR/TAP), member 8
, ATP-binding cassette sub-family B member 8, mitochondrial
, ATP-binding cassette, sub-family B, member 8
, ATP-binding cassette sub-family B member 8, mitochondrial-like
, mitochondrial ABC protein
, mitochondrial ATP-binding cassette 1
, ABC transporter 8