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Metallocarboxypeptidase that mediates tubulin deglutamylation. Additionally we are shipping ATP/GTP Binding Protein-Like 5 Antibodies (54) and many more products for this protein.
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Ccp5 is the principal tubulin (show TUBB Proteins) deglutamylase that maintains functional levels of cilia tubulin (show TUBB Proteins) glutamylation.
These data suggest that CCP1 (show AGTPBP1 Proteins) and CCP5 play important roles in developmental processes, particularly the development and functioning of cilia.
The identification of AGBL5 and TTLL5, a previously described RP-associated gene encoding the tubulin tyrosine ligase (show TTLL1 Proteins)-like family, member 5 protein, highlights the importance of poly- and deglutamylation in retinal homeostasis.
Due to the characteristic Retinitis Pigmentosa phenotype in patients carrying the AGBL5 missense mutation we suggest this gene as a candidate for a new form of autosomal recessively inherited RP
CCP5 (show GZMD Proteins) functions as a dual-functional deglutamylase cleaving both alpha- and gamma-linked glutamate (show GRIN1 Proteins) from tubulin (show TUBB Proteins).
Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post- translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains (By similarity).
ATP/GTP-binding protein-like 5
, cytosolic carboxypeptidase-like protein 5
, ATP/GTP binding protein-like 5
, cytosolic carboxypeptidase-like protein 5-like
, carboxypeptidase 5, cytosolic
, Cytosolic carboxypeptidase-like protein 5