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Involved in DNA damage response.
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Human Polyclonal ATAD5 Primary Antibody for EIA, WB - ABIN401276
Kanellis, Agyei, Durocher: Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability. in Current biology : CB 2003
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Mouse (Murine) Polyclonal ATAD5 Primary Antibody for ELISA - ABIN190859
Ishii, Inageta, Mimori, Saito, Sasaki, Isobe, Mori, Croce, Huebner, Ozawa, Furukawa: Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 2005
Authors discuss many functions of Elg1 protein as embryonic lethal when lost in mice, as a tumor suppressor in mice and humans, interacts with human Fanconi Anemia (show PALB2 Antibodies) pathway and may contribute to some of the phenotypes associated with neurofibromatosis. [Review]
Elg1 has an important role in maintaining chromosome integrity by regulating PCNA (show PCNA Antibodies) levels on chromatin, thereby acting as a PCNA (show PCNA Antibodies) unloading factor.
ATAD5 regulates the cycle of DNA replication factories, probably through its PCNA (show PCNA Antibodies)-unloading activity.
loss-of-function mutations in mammalian Atad5 are sufficient to cause genomic instability and tumorigenesis.
Studies indicate that USP1 (show USP1 Antibodies) and ELG1 as regulators of PCNA (show PCNA Antibodies) ubiquitylation.
Human ELG1 protein is stabilized and localized to form foci at sites of stalled DNA replications that are different from DNA double strand breaks foci.
The Frag1 signal pathway, by linking replication stress surveillance with apoptosis induction, plays a central role in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis.
Atad5+/m cells accumulate in the S phase, have decreased proliferation, and have reduced double-strand breaks, class switch recombination, and translocations
Involved in DNA damage response. Involved in a RAD9A- related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages- induced apoptosis.
ATPase family, AAA domain containing 5
, chromosome fragility associated gene 1
, ATPase family AAA domain-containing protein 5-like
, ATPase family AAA domain-containing protein 5
, chromosome fragility-associated gene 1 protein
, enhanced level of genomic instability 1 homolog
, enhanced level of genomic instability gene 1