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ATR Interacting Protein Proteins (ATRIP)

ATRIP encodes an essential component of the DNA damage checkpoint. Additionally we are shipping ATRIP Antibodies (108) and ATRIP Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ATRIP 84126 Q8WXE1
ATRIP 235610 Q8BMG1
Rat ATRIP ATRIP 301014  
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Top ATRIP Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details

ATRIP Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Mouse (Murine)

More Proteins for ATR Interacting Protein (ATRIP) Interaction Partners

Xenopus laevis ATR Interacting Protein (ATRIP) interaction partners

  1. ATRIP must associate with ATR in order for ATR to carry out the phosphorylation of Chk1 (show CHEK1 Proteins) effectively

  2. Data show that recombinant TopBP1 (show TOPBP1 Proteins) induces a large increase in the kinase activity of both Xenopus and human ATR-ATRIP.

Human ATR Interacting Protein (ATRIP) interaction partners

  1. ATRIP SUMOylation promotes ATR activation by providing a unique type of protein glue that boosts multiple protein interactions along the ATR pathway

  2. Data on crystal structure of BRCA1 binding with phosphopeptides suggest that C-terminal domain of BRCA1 interacts with ATRIP and BAAT1 (show C7orf27 Proteins) with preferences for specific side chains; in ATRIP, phospho-Ser239 and Phe242 are the main interacting residues.

  3. Data indicate that ATRIP is a direct target gene of HIF-1, and the increased ATRIP then activates the ATR signaling pathway under hypoxia.

  4. our analysis exposes an overlapping clinical manifestation between the disorders but allows an expanded spectrum of clinical features for ATR (show ANTXR1 Proteins)-ATRIP Seckel Syndrome to be defined

  5. as an ATR (show ANTXR1 Proteins)-associated kinase, Nek1 (show NEK1 Proteins) enhances the stability and activity of ATR (show ANTXR1 Proteins)-ATRIP before DNA damage, priming ATR (show ANTXR1 Proteins)-ATRIP for a robust DNA damage response

  6. ATRIP may function outside the context of the canonical ATR damage signaling pathway during HSV-1 infection to participate in the viral life cycle.

  7. data suggest that RPA (show RPA1 Proteins)-coated ssDNA is the critical structure at sites of DNA damage that recruits the ATR (show ANTXR1 Proteins)-ATRIP complex and facilitates its recognition of substrates for phosphorylation and the initiation of checkpoint signaling

  8. there are at least two in vitro ATR-ATRIP DNA binding complexes, one which binds DNA with high affinity in an RPA-dependent manner and a second, which binds DNA with lower affinity in an RPA-independent manner

  9. Collectively, our results suggest that the ATR (show ANTXR1 Proteins)-mediated phosphorylation of ATRIP at Ser (show SIGLEC1 Proteins)-68 and -72 is dispensable for the initial response to DNA damage.

  10. N-terminal domain of the ATRIP protein contributes to the cell cycle checkpoint by regulating the intranuclear localization of ATR

ATRIP Protein Profile

Protein Summary

This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ATRIP

  • ATR interacting protein (ATRIP)
  • ATR interacting protein (atrip)
  • ATR interacting protein (LOC100355293)
  • mutagen-sensitive 304 (mus304)
  • RAD26 protein (rad26)
  • ATRIP (rad26)
  • ATR interacting protein (Atrip)
  • 6620401K05Rik protein
  • anon-WO0140519.82 protein
  • atrip protein
  • CG7347 protein
  • Dmel\\CG7347 protein
  • mus(3)304 protein
  • mus-304 protein
  • Mus304 protein
  • si:dkey-42i9.5 protein
  • trex1 protein
  • Xatrip protein

Protein level used designations for ATRIP

ATR-interacting protein , three prime repair exonuclease 1 , ATR interacting protein , ATR-interacting protein-like , CG7347-PA , mus304-PA , mutagen sensitive 304 , ATRIP , ATM and Rad3-related-interacting protein , ATM and Rad3 related interacting protein

GENE ID SPECIES
415949 Gallus gallus
496388 Xenopus laevis
558534 Danio rerio
742205 Pan troglodytes
100063799 Equus caballus
100101245 Xenopus (Silurana) tropicalis
100355293 Oryctolagus cuniculus
100411124 Callithrix jacchus
100453171 Pongo abelii
40003 Drosophila melanogaster
443563 Xenopus laevis
2543289 Schizosaccharomyces pombe 972h-
100023426 Monodelphis domestica
100476250 Ailuropoda melanoleuca
100590808 Nomascus leucogenys
84126 Homo sapiens
235610 Mus musculus
301014 Rattus norvegicus
608504 Canis lupus familiaris
100523399 Sus scrofa
100125287 Bos taurus
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