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Inhibits activity of protein phosphatase 2A (PP2A). Additionally we are shipping ANP32E Antibodies (34) and ANP32E Proteins (8) and many more products for this protein.
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Dynamic modulation of H2A.Z (show H2AFZ ELISA Kits) exchange and removal by Anp32e reveals the importance of the nucleosome surface and nucleosome dynamics in processing the damaged chromatin template during DSB repair.
Anp32e may help to resolve the non-nucleosomal H2A.Z aggregates and also facilitate the removal of H2A.Z at the +1 nucleosomes, and the latter may help RNA polymerase II to pass the first nucleosomal barrier.
1.48 A resolution crystal structure of the complex formed between the ANP32E-ZID (show ZBTB6 ELISA Kits) and the H2A.Z (show H2AFZ ELISA Kits)/H2B dimer and biochemical data support an underlying molecular mechanism for H2A.Z (show H2AFZ ELISA Kits)/H2B eviction from the nucleosome and its stabilization by ANP32E
ANP32E gene mutations do not result in obvious motor activity defects.
combined deletion of Anp32a (show ANP32A ELISA Kits) and Anp32e also resulted in a viable and apparently healthy mouse. SIGNIFICANCE: These results provide evidence that significant functional redundancy exists among Anp32 (show ANP32A ELISA Kits) family members
Cpd-1 null mice are viable and fertile, but display a subtle neurological clasping phenotype and mild motor deficits.
This study propose that Anp32e/Cpd1 mediates synaptogenesis process by modulating Protein Phosphatase 2A activity.
Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis process by modulating PP2A activity.
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
, leucine-rich acidic nuclear phosphoprotein 32 family, member E
, similar to acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
, LANP-like protein
, acidic leucine-rich nuclear phosphoprotein 32 family member E
, leucine-rich acidic nuclear protein like
, cerebellar postnatal development protein 1