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Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) Proteins (ATF4)

ATF4 encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. Additionally we are shipping ATF4 Antibodies (274) and ATF4 Kits (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ATF4 468 P18848
ATF4 11911 Q06507
ATF4 79255 Q9ES19
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Top ATF4 Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human HIS-CaM 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$809.60
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,942.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,946.17
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$467.86
Details

ATF4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
, , ,
Mouse (Murine)
,
Rat (Rattus) ,
,

Top referenced ATF4 Proteins

  1. Human ATF4 Protein expressed in Escherichia coli (E. coli) - ABIN667937 : Hoeffler, Meyer, Yun, Jameson, Habener: Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. in Science (New York, N.Y.) 1989 (PubMed)
    Show all 2 references for ABIN667937

  2. Human ATF4 Protein expressed in Wheat germ - ABIN1345933 : Zhang, Khachigian et al.: Injury-induced platelet-derived growth factor receptor-alpha expression mediated by interleukin-1beta (IL-1beta) release and cooperative transactivation by NF-kappaB and ATF-4: IL-1beta facilitates ... in The Journal of biological chemistry 2009 (PubMed)

More Proteins for Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) Interaction Partners

Xenopus laevis Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) interaction partners

  1. Over-expression of atf4 in embryos interferes with neurogenesis and eye formation.

  2. Unlike other CREB2 (ATF4) proteins, the ATF4 isolated from the gonads of Xenopus embryos contains a consensus phosphorylation site for protein kinase A (PKA).

Human Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) interaction partners

  1. Inhibition or overexpression of ATF4 confirms the role of ATF4 in SESN2 (show SESN2 Proteins) gene up-regulation induced by mitochondrial dysfunction.

  2. ATF4 and ATF6beta (show ATF6B Proteins) act synergistically in the negative regulation of placental growth factor (show PGF Proteins) mRNA expression

  3. Authors observed that a slow rate of ATF4-translation and late re-initiation of general translation coincided with cells which were resistant to ER stress-induced cell death.

  4. a reduction of cell death was associated with decreased levels of ATF4 in a rhabdomyosarcoma cell line

  5. Combined administration inhibited the cells most potently and time-dependently, decreased the expression of HO-1 (show HMOX1 Proteins), and significantly increased the expression of ATF4, CHOP (show DDIT3 Proteins), and Ire-1 (show ERN1 Proteins) proteins expression levels

  6. Global profiling in human mesenchymal stem cells and a novel cell-free assay reveals that ATF4 requires C/EBPbeta (show CEBPB Proteins) for genomic binding at a motif distinct from that bound by the C/EBPbeta (show CEBPB Proteins) homodimer.

  7. This study outlines the mechanism of NIR (show NOC2L Proteins) laser phototoxicity and the utility of monitoring surface temperature and ATF4 expression as potential biomarkers to develop safe and effective clinical applications.

  8. Up-regulation of ATF4 is associated with Pancreatic Neuroendocrine Tumors.

  9. The ATF4/p75NTR (show NGFR Proteins)/IL-8 (show IL8 Proteins) signal pathway may have an important role in EndoMT induced by SFO.

  10. ATF4 is a potential biomarker for esophageal squamous cell carcinoma (ESCC) prognosis and its dysregulation may play a key role in the regulation of invasion and metastasis in ESCC.

Mouse (Murine) Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) interaction partners

  1. TFEB (show TFEB Proteins)-regulated signaling pathway for osteoblast differentiation is involved in ATF4/CHOP (show DDIT3 Proteins)-dependent signaling pathway.

  2. These findings identify C/EBPgamma (show CEBPG Proteins) as a novel antioxidant regulator and an obligatory ATF4 partner that controls redox homeostasis in normal and cancerous cells.

  3. Gcn2 (show EIF2AK4 Proteins) & Atf4 are involved in L-proline metabolism regulation in embryonic stem cells.

  4. This study outlines the mechanism of NIR (show NOC2L Proteins) laser phototoxicity and the utility of monitoring surface temperature and ATF4 expression as potential biomarkers to develop safe and effective clinical applications.

  5. ATF4 plays a pivotal role in functional expansion and repopulating efficiency of HSCs in developing FL

  6. results identify ursolic acid and tomatidine as potential agents and/or lead compounds for reducing ATF4 activity, weakness, and atrophy in aged skeletal muscle

  7. The CARE-LUC mouse model represents an innovative tool to investigate the eIF2alpha (show EIF2A Proteins)-ATF4 axis and to develop drugs targeting this important pathway in the remediation of related pathologies.

  8. exogenous overexpression of ATF4 in breast cancer cells may facilitate the recruitment of macrophages into tumor tissues and promote tumor angiogenesis and tumor growth indirectly.

  9. We conclude that ATF4 is a key regulator of the physiological state necessary for neuronal plasticity and memory.

  10. Elevation of ATF4, at least in liver, thus seems to be a shared feature of diets, drugs, genes, and developmental alterations that extend maximum lifespan in mice.

Pig (Porcine) Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) interaction partners

  1. expression levels of porcine ATF4 gene were up-regulated 60 days and 120 days after birth in both breeds and the expression level in Meishan pigs was obviously higher than that in Large White pigs

  2. Tissue transcription analysis revealed that both porcine CREB2 (show ATF2 Proteins) and CREB3 (show CREB3 Proteins) mRNA were ubiquitously detected in all examined tissues.

ATF4 Protein Profile

Protein Summary

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication.

Gene names and symbols associated with ATF4

  • activating transcription factor 4 (tax-responsive enhancer element B67) (ATF4)
  • activating transcription factor 4 (atf4-a)
  • activating transcription factor 4b1 (tax-responsive enhancer element B67) (atf4b1)
  • activating transcription factor 4 (atf4)
  • activating transcription factor 4b2 (atf4b2)
  • activating transcription factor 4 (ATF4)
  • activating transcription factor 4 (Atf4)
  • Atf-4 protein
  • ATF4 protein
  • ATF4C protein
  • C/ATF protein
  • CREB-2 protein
  • CREB2 protein
  • sb:eu681 protein
  • TAXREB67 protein
  • TXREB protein
  • wu:fb08f07 protein
  • wu:fj01c08 protein
  • wu:fk30b04 protein
  • zgc:85951 protein
  • zgc:171702 protein

Protein level used designations for ATF4

cyclic AMP-dependent transcription factor ATF-4 , activating transcription factor 4 (tax-responsive enhancer element B67) , cAMP-dependent transcription factor ATF-4 , activating transcription factor 4C , activating transcription factor 4 , DNA-binding protein TAXREB67 , cAMP response element-binding protein 2 , cAMP-responsive element-binding protein 2 , cyclic AMP-responsive element-binding protein 2 , tax-responsive enhancer element B67 , tax-responsive enhancer element-binding protein 67 , c/EBP-related ATF , tax-responsive enhancer element-binding protein 67 homolog , taxREB67 homolog , activating transcription factor ATF-4 , rATF-4

GENE ID SPECIES
395693 Gallus gallus
398804 Xenopus laevis
406514 Danio rerio
448005 Xenopus (Silurana) tropicalis
468334 Pan troglodytes
556410 Danio rerio
703965 Macaca mulatta
744513 Pan troglodytes
100216465 Ovis aries
468 Homo sapiens
11911 Mus musculus
79255 Rattus norvegicus
100732296 Cavia porcellus
474503 Canis lupus familiaris
100144302 Sus scrofa
509107 Bos taurus
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