anti-Activin A Receptor Type II-Like 1 (ACVRL1) Antibodies

ACVRL1 encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. Additionally we are shipping ACVRL1 Kits (26) and ACVRL1 Proteins (23) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ACVRL1 94 P37023
ACVRL1 25237 P80203
ACVRL1 11482 Q61288
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Top anti-ACVRL1 Antibodies at

Showing 10 out of 159 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB <b>WB Suggested Anti-ACVRL1 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
Cow Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of ALK1 staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of ALK1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of hACVRL1-L489 (ABIN392242) in Jurkat, HepG2 cell line lysates (35 µg/lane). ACVRL1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot of ACVRL1 Pab (ABIN392241). TOP LEFT: Mouse heart tissue lysate. Western blot analysis of ACVRL1 (arrow) using rabbit polyclonal ACVRL1 Antibody (N-term) (ABIN392241). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the ACVRL1 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated WB 400 μL Log in to see 10 to 11 Days
Human Rabbit Un-conjugated ELISA, IHC (p), WB Immunohistochemistry (IHC) analysis of paraffin-embedded Mouse Brain, antibody was diluted at 1:100. 100 μL Log in to see 16 Days
Human Rabbit Un-conjugated ELISA, IF, IHC, WB 100 μL Log in to see 16 Days
Human Goat Un-conjugated ELISA, WB Western Blot: ALK-1 Antibody [ABIN250173] - (2ug/ml) staining of MCF7 lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days

ACVRL1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-ACVRL1 Antibodies

  1. Human Polyclonal ACVRL1 Primary Antibody for FACS, IHC (p) - ABIN392241 : Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal ACVRL1 Primary Antibody for ELISA, WB - ABIN250173 : Johnson, Berg, Baldwin, Gallione, Marondel, Yoon, Stenzel, Speer, Pericak-Vance, Diamond, Guttmacher, Jackson, Attisano, Kucherlapati, Porteous, Marchuk: Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2. in Nature genetics 1996 (PubMed)

  3. Human Polyclonal ACVRL1 Primary Antibody for IHC, IHC (p) - ABIN4279393 : Cunha, Pardali, Thorikay, Anderberg, Hawinkels, Goumans, Seehra, Heldin, ten Dijke, Pietras: Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis. in The Journal of experimental medicine 2010 (PubMed)

  4. Human Polyclonal ACVRL1 Primary Antibody for WB - ABIN1944774 : Berg, Gallione, Stenzel, Johnson, Allen, Schwartz, Jackson, Porteous, Marchuk: The activin receptor-like kinase 1 gene: genomic structure and mutations in hereditary hemorrhagic telangiectasia type 2. in American journal of human genetics 1997 (PubMed)
    Show all 3 Pubmed References

More Antibodies against ACVRL1 Interaction Partners

Cow (Bovine) Activin A Receptor Type II-Like 1 (ACVRL1) interaction partners

  1. Results show that ALK5 (show TGFBR1 Antibodies) and ALK1 play antagonistic roles in TGF-beta (show TGFB1 Antibodies)-induced podosome formation in aortic endothelial cells.

  2. ALK1 and ALK5 are both essential for correct regulation of VEGF, and that disruption of either pathway leads to disease.

Zebrafish Activin A Receptor Type II-Like 1 (ACVRL1) interaction partners

  1. alk1 loss has no effect on arterial endothelial cell proliferation but alters arterial endothelial cell migration within lumenized vessels.

  2. Control of Notch (show NOTCH1 Antibodies) targets in arterial endothelium is context-dependent, with gene-specific and region-specific requirements for Notch (show NOTCH1 Antibodies) and Alk1

  3. Blood flow is required not only for alk1 expression but also for Alk1 activity.

  4. Study demonstrate that alk1 expression requires blood flow, and despite normal levels of shear stress, some flow-responsive genes are dysregulated in alk1 mutant arterial endothelial cells.

  5. vbg encodes activin receptor-like kinase 1 (acvrl1), a TGFbeta (show TGFB1 Antibodies) type I receptor that is expressed predominantly in the endothelium of the vessels that become dilated in vbg mutants.

Human Activin A Receptor Type II-Like 1 (ACVRL1) interaction partners

  1. Study showed that rs706819, rs2293094, and rs11169953 polymorphisms in the ACVRL1 gene are associated with higher susceptibility to brain arteriovenous malformations.

  2. c.1027C > T(p.Gln343) mutation within the ACVRL1 gene in family with hereditary hemorrhagic telangiectasia

  3. Bone morphogenetic protein (BMP)9 (show GDF2 Antibodies) and BMP10 (show BMP10 Antibodies) are high affinity ligands for activin receptor-like kinase 1 (ALK1).

  4. Activin receptor-like kinase (ALK)1 is a transforming growth factor beta (TGF-beta) type I receptor (show TGFBR1 Antibodies) predominantly expressed in actively proliferating endothelial cells (ECs).

  5. Two novel missense mutations and two recurrent mutations in the ACVRL1 gene are associated with pulmonary arterial hypertension in in Chinese families.

  6. ALK1 expression and microvessel density are increased in oral lichen planus , particularly in atrophic/erosive OLP type.

  7. The genetic-interactions among BMPR-2 (show BMPR2 Antibodies), ALK-1, and 5-HTT (show SLC6A4 Antibodies) polymorphisms, elevated BMP-2 (show BMP2 Antibodies) and 5-HT (show DDC Antibodies) levels and differential gene expression substantiated the strong genetic contribution in high altitude pulmonary edema pathophysiology.

  8. Study of four patients with pulmonary arterial hypertension associated with human immunodeficiency virus infection found predisposing mutations in the BMPR2 (show BMPR2 Antibodies), ACVRL1 and ENG (show ENG Antibodies) genes.

  9. The preponderance of ACVRL1 mutations was due to founder mutations, specifically, c.830C>A (p.Thr277Lys), which was found in 24 families from the same geographical area of Norway.

  10. Report interaction between ALK1 signaling and connexin40 in the development of arteriovenous malformations.

Mouse (Murine) Activin A Receptor Type II-Like 1 (ACVRL1) interaction partners

  1. These data indicate that both Itgb8 and Alk1 are important in maintaining normal cerebral angiogenesis in response to VEGF (show VEGFA Antibodies). Itgb8 deficiency enhances the formation of dysplastic vessels and hemorrhage in Alk1 (+/-) mice.

  2. these studies characterize an accessory TGF-beta (show TGFB1 Antibodies)-stimulated BMP R-Smad (show SMAD1 Antibodies) signaling mechanism in interstitial cells of the developing lung.

  3. this study demonstrates that ACVRL1 signaling plays a pivotal role whereby it suppresses plasmacytoid dendritic cell development while enhancing that of CD8alpha(+) dendritic cells, thus contributing to DC diversity development.

  4. CD109 (show CD109 Antibodies) differentially regulates TGF-beta (show TGFB1 Antibodies)-induced ALK1-Smad1 (show SMAD1 Antibodies)/5 versus ALK5 (show TGFBR1 Antibodies)-Smad2 (show SMAD2 Antibodies)/3 pathways, leading to decreased extracellular matrix production in the skin; epidermal CD109 (show CD109 Antibodies) expression regulates dermal function through a paracrine mechanism

  5. he results of the present study demonstrated that BMP9 (show GDF2 Antibodies) promoted the osteoclast differentiation of osteoclast precursors via binding to the ALK1 receptor on the cell surface, and inhibiting the ERK1/2 (show MAPK1/3 Antibodies) signaling pathways in the cell

  6. Conclude that the ALK-1 receptor is involved in the control of arterial pressure. High AP of Alk1(+/-) mice is explained mainly by the sympathetic overactivation, which is probably related to the decreased number of cholinergic neurons.

  7. Report interaction between ALK1 signaling and connexin40 in the development of arteriovenous malformations.

  8. In vascular sprouting, neuropilin-1 (show NRP1 Antibodies) suppresses the stalk-cell phenotype by limiting Smad2 (show SMAD2 Antibodies)/3 activation through Alk1 and Alk5 (show TGFBR1 Antibodies). Notch (show NOTCH1 Antibodies) downregulates Nrp1 (show NRP1 Antibodies), thus relieving the inhibition of Alk1 and Alk5 (show TGFBR1 Antibodies), thereby driving stalk-cell behaviour.

  9. BMP9 (show GDF2 Antibodies)/ALK1 augmented vasculogenesis and angiogenesis, and thereby enhanced neovascularization. Thus, we suggest that BMP9 (show GDF2 Antibodies)/ALK1 may improve the efficacy of EPC (show TCF21 Antibodies)-based therapies for treating ischemic diseases.

  10. BMP-9 (show GDF2 Antibodies) induces vascular smooth muscle cell osteogenic differentiation and calcification via ALK1, Smad (show SMAD1 Antibodies) and ALP (show CCL21A Antibodies) dependent mechanisms.

ACVRL1 Antigen Profile

Protein Summary

This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.

Gene names and symbols associated with ACVRL1

  • activin A receptor like type 1 (ACVRL1) antibody
  • activin A receptor type II-like 1 (ACVRL1) antibody
  • activin A receptor like type 1 (acvrl1) antibody
  • activin A receptor like type 1 (Acvrl1) antibody
  • activin A receptor, type II-like 1 (Acvrl1) antibody
  • ACVRL1 antibody
  • Acvrlk1 antibody
  • AI115505 antibody
  • AI427544 antibody
  • ALK-1 antibody
  • Alk1 antibody
  • HHT antibody
  • HHT2 antibody
  • hm:zehn1109 antibody
  • ORW2 antibody
  • R-3 antibody
  • R3 antibody
  • SETHKIR antibody
  • SKR3 antibody
  • TSR-I antibody
  • vgb antibody
  • zehn1109 antibody

Protein level used designations for ACVRL1

activin A receptor type II-like 1 , serine/threonine-protein kinase receptor R3 , serine/threonine-protein kinase receptor R3-like , activin receptor-like kinase 1 , vbg , violet beauregarde , TGF-B superfamily receptor type I , activin A receptor, type II-like kinase 1 , Activin receptor like kinase 1 , SKR3 , TSR-I , ALK-1 , activin receptor-like kinase-1

451910 Pan troglodytes
534536 Bos taurus
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100135773 Felis catus
100482358 Ailuropoda melanoleuca
266753 Danio rerio
94 Homo sapiens
25237 Rattus norvegicus
477603 Canis lupus familiaris
100153279 Sus scrofa
100172614 Pongo abelii
11482 Mus musculus
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