ACVRL1 antibody (N-Term)

Catalog No. ABIN392241

Cited in 4+ publications. The Rabbit Polyclonal anti-ACVRL1 antibody (Clone RB03736) (ABIN392241) specifically detects ACVRL1 in WB, FACS and IHC (p). The antibody is reactive with Human and Mouse samples.

Quick Overview for ACVRL1 antibody (N-Term) (ABIN392241)

Target: ACVRL1 (Activin A Receptor Type II-Like 1 (ACVRL1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACVRL1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB03736

Product Details anti-ACVRL1 Antibody

Binding Specificity: AA 38-68, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This ACVRL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-68 amino acids from the N-terminal region of human ACVRL1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-ACVRL1 antibody (ABIN392241)

Muñoz-Félix, Cuesta, Perretta-Tejedor, Subileau, López-Hernández, López-Novoa, Martínez-Salgado: "Identification of bone morphogenetic protein 9 (BMP9) as a novel profibrotic factor in vitro." in: Cellular signalling, Vol. 28, Issue 9, pp. 1252-61, (2017) (PubMed).

Antonov, Antonova, Fujii, ten Dijke, Handa, Catravas, Verin: "Regulation of endothelial barrier function by TGF-? type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90." in: Journal of cellular physiology, Vol. 227, Issue 2, pp. 759-71, (2011) (PubMed).

Finnson, Parker, ten Dijke, Thorikay, Philip: "ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 23, Issue 6, pp. 896-906, (2008) (PubMed).

Yu, Pisitkun, Wang, Shen, Knepper: "LC-MS/MS analysis of apical and basolateral plasma membranes of rat renal collecting duct cells." in: Molecular & cellular proteomics : MCP, Vol. 5, Issue 11, pp. 2131-45, (2006) (PubMed).

Target Details for ACVRL1

Target: ACVRL1 (Activin A Receptor Type II-Like 1 (ACVRL1))

Alternative Name: ACVRL1

Background: ACVRL1 is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. This protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.

Molecular Weight: 56124

Gene ID: 94

NCBI Accession: NP_000011, NP_001070869

UniProt: P37023