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Activin Receptor Type I Proteins (ACRV1)

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Additionally we are shipping Activin Receptor Type I Antibodies (148) and Activin Receptor Type I Kits (23) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACRV1 11477 P37172
ACRV1 90 Q04771
ACRV1 79558 P80201
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Top Activin Receptor Type I Proteins at antibodies-online.com

Showing 10 out of 29 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human His tag,Fc Tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Mouse His tag,Fc Tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Dog His tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Cynomolgus Fc Tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Human Cells Rat Fc Tag 100 μg Log in to see 16 Days
$250.80
Details
HOST_Baculovirus infected Insect Cells Human His tag 100 μg Log in to see 16 Days
$272.80
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
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HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details

ACRV1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
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Human , , , ,
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Rat (Rattus) ,
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Top referenced Activin Receptor Type I Proteins

  1. Human ACRV1 Protein expressed in Human Cells - ABIN2002388 : Attisano, Cárcamo, Ventura, Weis, Massagué, Wrana: Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors. in Cell 1993 (PubMed)
    Show all 5 references for ABIN2002388

  2. Human ACRV1 Protein expressed in Baculovirus infected Insect Cells - ABIN3218786 : ten Dijke, Yamashita, Ichijo, Franzén, Laiho, Miyazono, Heldin: Characterization of type I receptors for transforming growth factor-beta and activin. in Science (New York, N.Y.) 1994 (PubMed)
    Show all 5 references for ABIN3218786

  3. Cynomolgus ACRV1 Protein expressed in Human Cells - ABIN2009781 : Macías-Silva, Hoodless, Tang, Buchwald, Wrana: Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. in The Journal of biological chemistry 1998 (PubMed)
    Show all 5 references for ABIN2009781

  4. Rat (Rattus) ACRV1 Protein expressed in Human Cells - ABIN2009190 : Shore, Xu, Feldman, Fenstermacher, Cho, Choi, Connor, Delai, Glaser, LeMerrer, Morhart, Rogers, Smith, Triffitt, Urtizberea, Zasloff, Brown, Kaplan: A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. in Nature genetics 2006 (PubMed)
    Show all 5 references for ABIN2009190

  5. Dog (Canine) ACRV1 Protein expressed in Human Cells - ABIN2008893 : Renlund, ONeill, Zhang, Sidis, Teixeira: Activin receptor-like kinase-2 inhibits activin signaling by blocking the binding of activin to its type II receptor. in The Journal of endocrinology 2007 (PubMed)
    Show all 5 references for ABIN2008893

More Proteins for Activin Receptor Type I (ACRV1) Interaction Partners

Mouse (Murine) Activin Receptor Type I (ACRV1) interaction partners

  1. Suggest that BMP signaling upregulates the calcineurin (show PPP3CA Proteins)/nuclear factor of activated T cell (show NFATC3 Proteins) pathway via BMP type I receptor ALK2, contributing to cardiac hypertrophy and fibrosis.

  2. results suggest that ACVR1(R206H) causes FOP (show CHTOP Proteins) by gaining responsiveness to the normally antagonistic ligand activin A (show INHBA Proteins), demonstrating that this ligand is necessary and sufficient for driving HO in a genetically accurate model of FOP (show CHTOP Proteins)

  3. The findings suggest that the mutant ALK2 related to Fibrodysplasia ossificans progressiva is enhanced by bone morphogenetic protein type II receptors via the T203-regulated phosphorylation of ALK2.

  4. ACVR1 is required for chondrocyte proliferation and differentiation, particularly in craniofacial and axial elements, but exerts coordinated functions with both BMPR1A (show BMPR1A Proteins) and BMPR1B (show BMPR1B Proteins) throughout the developing endochondral skeleton

  5. expression of constitutively active ALK2 receptor results in significantly increased ASC (show STS Proteins) osteogenic differentiation.

  6. SP-10 is a useful marker for staging the cycle of the seminiferous epithelium. The anti-SP-10 antibody works well in different fixatives, on paraffin-embedded as well as cryosections

  7. Data indicate that activin A receptor type 1 (Alk2) is a direct regulator of cartilage formation and mediates chondrogenic commitment of progenitor cells.

  8. Tmem176b (show TMEM176B Proteins) mRNA levels were upregulated by stable transfection of ALK2 (R206H) in mouse myoblastic C2C12 cells.

  9. AcvR1-mediated BMP signaling in second heart field is required for arterial pole development: implications for myocardial differentiation and regional identity.

  10. Our work clarifies the conserved mechanisms through which BMPs regulate peri (show POSTN Proteins)-implantation in rodents and primates and, for the first time, uncovers a linear pathway of BMP signaling through ALK2 to regulate CEBPB (show CEBPB Proteins)

Human Activin Receptor Type I (ACRV1) interaction partners

  1. Common mutations in ALK2/ACVR1, a multi-faceted receptor, have roles in distinct pediatric musculoskeletal and neural orphan disorders.

  2. The higher PE activin A (show INHBA Proteins) concentrations resulted in abnormal endothelial functions, which may contribute to the systemic maternal vascular endothelial cell dysfunction observed in the disorder.

  3. A report of two patients has been presented with multi-system involvement in a severe variant of fibrodysplasia ossificans progressiva caused by the ACVR1 c.772G>A; R258G mutation.

  4. Fibrodysplasia ossificans progressiva-ACVR1 abnormally transduces bone morphogenetic protein signaling in response to Activin-A (show INHBA Proteins).

  5. Changes in the binding site residue(e.g. pre-hinge region in ALK2) or side chain orientation (e.g. Tyr219 in caALK2 vs. wtALK2), or ligand modification (e.g. DMH1 vs. LDN193189) causes distinct binding profiles and selectivity among BMP inhibitors.

  6. heterozygous mutation i.e., c.617(G>A)in ACVR1 was detected in patients with rare genetic disorder - Fibrodysplasia ossificans progressiva

  7. miR (show MLXIP Proteins)-148a is an important mediator of ACVR1, thus offering a new potential target for the development of therapeutic agents against Fibrodysplasia ossificans progressiva.

  8. Genetic analysis of ACVR1 identified the recurrent allelic variant c.617 G>A; p.R206H in 12 of 14 Fibrodysplasia Ossificans Progressiva (FOP)patients. One of the remaining patients had a previously reported allele c.1067G>A; p.G356D in the 9th exon and the second allele c.983G>A; p.G328E in the 8th exon of ACVR1.

  9. clinically aggressive stem cell-like subtype of hepatocellular carcinoma characterized by miR (show MLXIP Proteins)-148a-ACVR1-BMP-Wnt (show WNT2 Proteins) circuit

  10. compounds demonstrated consistent binding to a panel of mutant and wild-type ALK2 proteins

Activin Receptor Type I (ACRV1) Protein Profile

Protein Summary

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Gene names and symbols associated with ACRV1

  • activin A receptor, type 1 (Acvr1)
  • activin A receptor, type I (ACVR1)
  • activin A receptor, type I (Acvr1)
  • ActR-I protein
  • ActR-IA protein
  • ACTRI protein
  • ActRIA protein
  • Acvr protein
  • ACVR1A protein
  • ACVRLK2 protein
  • Alk-2 protein
  • ALK2 protein
  • Alk8 protein
  • D330013D15Rik protein
  • FOP protein
  • SKR1 protein
  • Tsk7L protein
  • TSRI protein

Protein level used designations for ACRV1

TGF-B superfamily receptor type I , TSK-7L , TSR-I , activin receptor type I , activin receptor type-1 , serine/threonine-protein kinase receptor R1 , activin A receptor, type II-like kinase 2 , activin receptor-like kinase 2 , hydroxyalkyl-protein kinase , ACTR-I , SKR1 , activin A receptor, type 1 , activin type I receptor , type I TGF B receptor , activin A receptor, type I , activin receptor type IA

GENE ID SPECIES
11477 Mus musculus
90 Homo sapiens
478757 Canis lupus familiaris
338068 Bos taurus
79558 Rattus norvegicus
395246 Gallus gallus
443161 Ovis aries
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