Activin Receptor Type I Proteins (ACRV1)

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Additionally we are shipping Activin Receptor Type I Antibodies (168) and Activin Receptor Type I Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACRV1 11477 P37172
ACRV1 90 Q04771
ACRV1 79558 P80201
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Top Activin Receptor Type I Proteins at antibodies-online.com

Showing 10 out of 35 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Human Cells Human Fc Tag,His tag 100 μg Log in to see 20 to 21 Days
$250.80
Details
HOST_Human Cells Mouse Fc Tag,His tag 100 μg Log in to see 20 to 21 Days
$250.80
Details
HOST_Baculovirus infected Insect Cells Human His tag 100 μg Log in to see 20 to 21 Days
$272.80
Details
HOST_Human Cells Rat Fc Tag 100 μg Log in to see 20 to 21 Days
$250.80
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HOST_Human Cells Dog His tag 100 μg Log in to see 20 to 21 Days
$250.80
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HOST_Human Cells Cynomolgus Fc Tag 100 μg Log in to see 20 to 21 Days
$250.80
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$4,244.78
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
$608.00
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details

ACRV1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , ,
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Rat (Rattus) ,
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Top referenced Activin Receptor Type I Proteins

  1. Human ACRV1 Protein expressed in Human Cells - ABIN2002388 : Attisano, Cárcamo, Ventura, Weis, Massagué, Wrana: Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors. in Cell 1993 (PubMed)
    Show all 5 references for 2002388

  2. Cynomolgus ACRV1 Protein expressed in Human Cells - ABIN2009781 : ten Dijke, Yamashita, Ichijo, Franzén, Laiho, Miyazono, Heldin: Characterization of type I receptors for transforming growth factor-beta and activin. in Science (New York, N.Y.) 1994 (PubMed)
    Show all 5 references for 2009781

  3. Rat (Rattus) ACRV1 Protein expressed in Human Cells - ABIN2009190 : Macías-Silva, Hoodless, Tang, Buchwald, Wrana: Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. in The Journal of biological chemistry 1998 (PubMed)
    Show all 5 references for 2009190

  4. Dog (Canine) ACRV1 Protein expressed in Human Cells - ABIN2008893 : Shore, Xu, Feldman, Fenstermacher, Cho, Choi, Connor, Delai, Glaser, LeMerrer, Morhart, Rogers, Smith, Triffitt, Urtizberea, Zasloff, Brown, Kaplan: A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. in Nature genetics 2006 (PubMed)
    Show all 5 references for 2008893

  5. Human ACRV1 Protein expressed in Baculovirus infected Insect Cells - ABIN3218786 : Renlund, ONeill, Zhang, Sidis, Teixeira: Activin receptor-like kinase-2 inhibits activin signaling by blocking the binding of activin to its type II receptor. in The Journal of endocrinology 2007 (PubMed)
    Show all 5 references for 3218786

More Proteins for Activin Receptor Type I (ACRV1) Interaction Partners

Mouse (Murine) Activin Receptor Type I (ACRV1) interaction partners

  1. The authors demonstrated that ubiquitin-specific protease (USP) 4 (show USP4 Proteins) strongly induces activin/BMP signaling by removing the inhibitory monoubiquitination from SMAD4 (show SMAD4 Proteins).

  2. Enhanced SMAD (show SMAD1 Proteins)-dependent BMP signaling through constitutively active ACVR1 in palatal epithelium causes submucous cleft palate in mice, via medial-edge-epithelium persistence presumably due to the up regulation of DeltaNp63 andresultingreductionofcaspase-3 activation. 2.

  3. BMP signaling mediated by coordination of ALK2/ACVR1, ALK3/BMPR1A (show BMPR1A Proteins), and BMPR2 (show BMPR2 Proteins) is an essential proangiogenic cue for retinal vessels.

  4. This study showed that Gja1 (show GJA1 Proteins) may act downstream of cAMP-PKA signal to mediate the effects of Acvr1 on the differentiation of uterine stromal cells through targeting Hand2 (show HAND2 Proteins).

  5. Results showed activin-C and follistatin are differentially expressed during prostate development and suggested that the antagonistic property of follistatin is secondary to the action of activin-C. Study provides evidence to support a role of activin-C in prostate development and provides new insights in the spatiotemporal localization of activins and their antagonists during mouse prostate development.

  6. BMPR1B plays distinct roles from BMPR1A and ACVR1 in maintaining bone mass and transducing BMP signaling

  7. Suggest that BMP signaling upregulates the calcineurin (show PPP3CA Proteins)/nuclear factor of activated T cell (show NFATC3 Proteins) pathway via BMP type I receptor ALK2, contributing to cardiac hypertrophy and fibrosis.

  8. results suggest that ACVR1(R206H) causes FOP (show CHTOP Proteins) by gaining responsiveness to the normally antagonistic ligand activin A (show INHBA Proteins), demonstrating that this ligand is necessary and sufficient for driving HO in a genetically accurate model of FOP (show CHTOP Proteins)

  9. The findings suggest that the mutant ALK2 related to Fibrodysplasia ossificans progressiva is enhanced by bone morphogenetic protein type II receptors via the T203-regulated phosphorylation of ALK2.

  10. ACVR1 is required for chondrocyte proliferation and differentiation, particularly in craniofacial and axial elements, but exerts coordinated functions with both BMPR1A (show BMPR1A Proteins) and BMPR1B (show BMPR1B Proteins) throughout the developing endochondral skeleton

Human Activin Receptor Type I (ACRV1) interaction partners

  1. Data suggest BMP9/GDF2 (show GDF2 Proteins) and BMP10 (show BMP10 Proteins) synergize with TNFA (show TNF Proteins) to increase monocyte recruitment to vascular endothelial cells; process appears to be mediated mainly via ALK2/ACVR1 (which exhibits protein kinase (show CDK7 Proteins) activity). These studies used in vitro flow monocyte adhesion assay. (BMP9 (show GDF2 Proteins) = growth differentiation factor 2 (show GDF2 Proteins); BMP10 (show BMP10 Proteins) = bone morphogenetic protein 10 (show BMP10 Proteins); TNFA (show TNF Proteins) = tumor necrosis factor alpha (show TNF Proteins); ALK2/ACVR1 = activin A receptor type 1)

  2. The effects of ACVR1/ALK2 mutations causing fibrodysplasia ossificans progressiva are extended to the central nervous system. Brainstem hamartomatous lesions and dysmorphisms, variably associated with dentate nucleus and basal ganglia signal abnormalities and/or calcifications, may represent useful disease hallmarks.

  3. Low ALK2 expression is associated with invasiveness of breast cancer.

  4. Further investigation on clinical ESCC samples and non-tumorous adjacent tissue found that tumors with triple-positive BMP6 (show BMP6 Proteins), ALK2 and BMPRII (show BMPR2 Proteins) had deeper growth than tumors with only BMP6 (show BMP6 Proteins) expression

  5. The clinical manifestations, the disease course, and the molecular findings of involvement of ACVR1 gene in this family are suggestive of "FOP variant" or an unusual ACVR1-related skeletal dysplasia

  6. Activin-A (show INHBA Proteins) is increased in the airway of asthmatics and peaks during asthma exacerbations.Activin-A signalling pathways are dysregulated in severe asthma.

  7. Common mutations in ALK2/ACVR1, a multi-faceted receptor, have roles in distinct pediatric musculoskeletal and neural orphan disorders.

  8. The higher PE activin A (show INHBA Proteins) concentrations resulted in abnormal endothelial functions, which may contribute to the systemic maternal vascular endothelial cell dysfunction observed in the disorder.

  9. A report of two patients has been presented with multi-system involvement in a severe variant of fibrodysplasia ossificans progressiva caused by the ACVR1 c.772G>A; R258G mutation.

  10. Fibrodysplasia ossificans progressiva-ACVR1 abnormally transduces bone morphogenetic protein signaling in response to Activin-A (show INHBA Proteins).

Activin Receptor Type I (ACRV1) Protein Profile

Protein Summary

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Gene names and symbols associated with ACRV1

  • activin A receptor, type 1 (Acvr1)
  • activin A receptor, type I (ACVR1)
  • activin A receptor, type I (Acvr1)
  • ActR-I protein
  • ActR-IA protein
  • ACTRI protein
  • ActRIA protein
  • Acvr protein
  • ACVR1A protein
  • ACVRLK2 protein
  • Alk-2 protein
  • ALK2 protein
  • Alk8 protein
  • D330013D15Rik protein
  • FOP protein
  • SKR1 protein
  • Tsk7L protein
  • TSRI protein

Protein level used designations for ACRV1

TGF-B superfamily receptor type I , TSK-7L , TSR-I , activin receptor type I , activin receptor type-1 , serine/threonine-protein kinase receptor R1 , activin A receptor, type II-like kinase 2 , activin receptor-like kinase 2 , hydroxyalkyl-protein kinase , ACTR-I , SKR1 , activin A receptor, type 1 , activin type I receptor , type I TGF B receptor , activin A receptor, type I , activin receptor type IA

GENE ID SPECIES
11477 Mus musculus
90 Homo sapiens
478757 Canis lupus familiaris
338068 Bos taurus
79558 Rattus norvegicus
395246 Gallus gallus
443161 Ovis aries
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