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The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. Additionally we are shipping Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Antibodies (69) and many more products for this protein.
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APPL1 positively mediated leptin (show LEP Proteins) signaling.
Decreased expression of APPL1 is associated with polycystic ovary syndrome.
Results indicate that persistent rab5 (show RAB5A Proteins) overactivation through beta-cleaved carboxy-terminal fragment of APP (show APP Proteins)-APPL1 interactions constitutes a novel APP (show APP Proteins)-dependent pathogenic pathway in Alzheimer's disease
Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.
Low expression of APPL1 is associated with metastasis in prostate cancer.
APPL1 endosomes represent a distinct population of Rab5 (show RAB5A Proteins)-positive sorting endosomes.
article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD
Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.
A role for APPL1 in TLR3 (show TLR3 Proteins)/4-dependent TBK1 (show TBK1 Proteins) and IKKepsilon (show IKBKE Proteins) activation in macrophages.
ATM (show ATM Proteins) is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.
Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (show HGF Proteins)-induced Akt (show AKT1 Proteins) activation, migration, and invasion.
In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (show PRKAA1 Proteins) signaling.
APPL1 sensitizes insulin (show INS Proteins) signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin (show INS Proteins) signaling and crosstalk between the insulin (show INS Proteins) and adiponectin (show ADIPOQ Proteins) pathways.
Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.
APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (show INS Proteins) sensitivity.
Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (show INS Proteins) resistance and improves adipoR1 (show ADIPOR1 Proteins)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue
APPL1 contributes to connecting synaptic NMDA receptors with the intracellular phosphoinositide 3-kinase /Akt (show AKT1 Proteins) cascade in neurons.
Reduced APPL1 expression in pancreatic islets may serve as a pathological link that couples insulin (show INS Proteins) resistance to beta-cell dysfunction in type 2 diabetes.
Endurance training was able to increase APPL1 expression.
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.
, DCC-interacting protein 13-alpha
, adapter protein containing PH domain, PTB domain and leucine zipper motif 1
, adaptor protein containing pH domain, PTB domain and leucine zipper motif 1
, signaling adaptor protein DIP13alpha
, DIP13 alpha
, adaptor protein APPL like