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Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Proteins (APPL2)

The protein encoded by APPL2 is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Additionally we are shipping Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Antibodies (32) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat APPL2 APPL2 362860  
APPL2 55198 Q8NEU8
APPL2 216190 Q8K3G9
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Top Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
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APPL2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) Interaction Partners

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) interaction partners

  1. ATM (show ATM Proteins) is the central modulator of APPL (show APPL1 Proteins)-mediated effects on radiosensitivity and DNA repair.

  2. It concludes that APPL2 (show APLP2 Proteins)(PH) binding to BAR domain and Reptin (show RUVBL2 Proteins) is mutually exclusive which regulates the nucleocytoplasmic shuttling of Reptin (show RUVBL2 Proteins).

  3. C-APPL1 (show APPL1 Proteins)/A-APPL2 (show APLP2 Proteins) allele combination is associated with non-alcoholic fatty liver disease occurrence, with a more severe hepatic steatosis grade and with a reduced adiponectin (show ADIPOQ Proteins) cytoprotective effect on liver.

  4. Data indicate that a high level of APPL2 (show APLP2 Proteins) protein might enhance glioblastoma growth by maintaining low expression level of genes responsible for cell death induction.

  5. analysis of APPL1 (show APPL1 Proteins) and APPL2 (show APLP2 Proteins) proteins and their interaction with Rab (show HRB Proteins)

  6. Genetic variation(s) in APPL1/2 may be associated with CAD risk in T2DM in Chinese population.

  7. Data suggest that although annexin A2 (show ANXA2 Proteins) is not an exclusive marker of APPL1 (show APPL1 Proteins)/2 endosomes, it has an important function in membrane recruitment of APPL (show APPL1 Proteins) proteins, acting in parallel to Rab5 (show RAB5A Proteins).

  8. significant fluorescence resonance energy transfer between APPL (show APPL1 Proteins) minimal BAR domain FRET pairs

  9. identification of a pathway directly linking the small GTPase (show RACGAP1 Proteins) Rab5 (show RAB5A Proteins), a key regulator of endocytosis, to signal transduction and mitogenesis via APPL1 (show APPL1 Proteins) and APPL2 (show APLP2 Proteins), two Rab5 (show RAB5A Proteins) effectors

  10. The findings suggest a role for APPL1 (show APPL1 Proteins) and APPL2 (show APLP2 Proteins) protein as dynamic scaffolds that modulate RAB5 (show RAB5A Proteins)-associated signaling endosomal membranes by their ability to undergo domain-mediated oligomerization, membrane targeting and phosphoinositide binding.

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) interaction partners

  1. Appl1 (show APPL1 Proteins)/2-null mouse embryonic fibroblasts exhibited defects in HGF (show HGF Proteins)-induced Akt (show AKT1 Proteins) activation, migration, and invasion.

  2. Rab31 (show RAB31 Proteins), with APPL2 as its effector, play a role in FcgammaR-mediated phagocytosis through PI3K/Akt (show AKT1 Proteins) signaling in macrophages.

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2) Protein Profile

Protein Summary

The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.

Gene names and symbols associated with APPL2

  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (Appl2)
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (APPL2)
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (appl2)
  • amyloid beta (A4) precursor-like protein 2 (APLP2)
  • APPL2 protein
  • Dip3b protein
  • DIP13B protein
  • MGC84621 protein
  • RGD1563028 protein

Protein level used designations for APPL2

DCC-interacting protein 13-beta , adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 , amyloid beta (A4) precursor-like protein 2 , DIP13 beta , adapter protein containing PH domain, PTB domain and leucine zipper motif 2 , Dip3 beta , dip13-beta

GENE ID SPECIES
362860 Rattus norvegicus
418075 Gallus gallus
447596 Xenopus laevis
515605 Bos taurus
100000135 Danio rerio
100127202 Xenopus (Silurana) tropicalis
100545199 Meleagris gallopavo
100563730 Anolis carolinensis
100604575 Nomascus leucogenys
55198 Homo sapiens
216190 Mus musculus
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