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The protein encoded by APPL2 is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Additionally we are shipping Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 Antibodies (34) and many more products for this protein.
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Results show the suppressive effect of OCC-1 RNA on transcription level of the APPL2 (show APLP2 Proteins) gene provides a putative colorectal neoplasm progression index.
Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.
ATM (show ATM Proteins) is the central modulator of APPL (show APPL1 Proteins)-mediated effects on radiosensitivity and DNA repair.
It concludes that APPL2 (show APLP2 Proteins)(PH) binding to BAR domain and Reptin (show RUVBL2 Proteins) is mutually exclusive which regulates the nucleocytoplasmic shuttling of Reptin (show RUVBL2 Proteins).
C-APPL1/A-APPL2 allele combination is associated with non-alcoholic fatty liver disease occurrence, with a more severe hepatic steatosis grade and with a reduced adiponectin cytoprotective effect on liver.
Data indicate that a high level of APPL2 (show APLP2 Proteins) protein might enhance glioblastoma growth by maintaining low expression level of genes responsible for cell death induction.
analysis of APPL1 (show APPL1 Proteins) and APPL2 (show APLP2 Proteins) proteins and their interaction with Rab (show HRB Proteins)
Genetic variation(s) in APPL1/2 may be associated with CAD risk in T2DM in Chinese population.
Data suggest that although annexin A2 (show ANXA2 Proteins) is not an exclusive marker of APPL1 (show APPL1 Proteins)/2 endosomes, it has an important function in membrane recruitment of APPL (show APPL1 Proteins) proteins, acting in parallel to Rab5 (show RAB5A Proteins).
significant fluorescence resonance energy transfer between APPL (show APPL1 Proteins) minimal BAR domain FRET pairs
Here we establish potential roles for APPL1 (show APPL1 Proteins) and 2 signaling adaptors as regulators of LPS/TLR4 (show TLR4 Proteins)-induced signaling, transcription, and cytokine secretion.
Appl1 (show APPL1 Proteins)/2-null mouse embryonic fibroblasts exhibited defects in HGF (show HGF Proteins)-induced Akt (show AKT1 Proteins) activation, migration, and invasion.
Rab31 (show RAB31 Proteins), with APPL2 as its effector, play a role in FcgammaR-mediated phagocytosis through PI3K/Akt (show AKT1 Proteins) signaling in macrophages.
The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.
DCC-interacting protein 13-beta
, adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
, amyloid beta (A4) precursor-like protein 2
, DIP13 beta
, adapter protein containing PH domain, PTB domain and leucine zipper motif 2
, Dip3 beta