Adenosine Deaminase, RNA-Specific, B1 (ADARB1) ELISA Kits

ADARB1 encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Additionally we are shipping RED1 Antibodies (35) and RED1 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ADARB1 104 P78563
ADARB1 110532 Q91ZS8
ADARB1 25367 P51400
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Human Adenosine Deaminase, RNA-Specific, B1 (ADARB1) interaction partners

  1. 2-way interaction between TPH2 (show TDO2 ELISA Kits) rs4290270 and general traumas revealed that TT homozygotes with history of general traumas had an increased risk for suicide attempt. 3-way interaction of general traumas, TPH2 (show TDO2 ELISA Kits) rs4290270 and ADARB1 rs4819035 indicated that highest predisposition to suicide attempt was observed in individuals who experienced general traumas and were TT homozygote for rs4290270 and TT homozygote for rs4819035.

  2. The range of human disease associated with ADAR1 (show ADAR ELISA Kits) mutations may extend further to include other inflammatory conditions while ADAR2 mutations may affect psychiatric conditions.

  3. Four crystal structures of the human ADAR2 deaminase domain bound to RNA duplexes bearing a mimic of the deamination reaction intermediate.

  4. we determined the importance of specific amino acids at 19 different positions in the ADAR2 5' binding loop and revealed six residues that provide essential structural elements supporting the fold of the loop and key RNA-binding functional groups. This work provided new insight into RNA recognition by ADAR2 and established a new tool for defining structure-function relationships in ADAR (show ADAR ELISA Kits) reactions.

  5. Data indicate that ADAR2 suppresses tumor growth and induces apoptosis by editing and stabilizing IGFBP7 (show IGFBP7 ELISA Kits) in esophageal squamous cell carcinoma.

  6. These findings suggest that adenosine deaminase acting on RNA (show ADAR ELISA Kits) 2 is subject to different regulations by DNA methyltransferase (show DNMT1 ELISA Kits) and histone deacetylase (show HDAC1 ELISA Kits) enzymes in neuronal SH-SY5Y cells.

  7. These data suggest that, like ADAR2, underlying sequences in dsRNA may influence how NF90 (show MMP4 ELISA Kits) recognizes its target RNAs

  8. Detailed structural analysis indicates that the minor groove width of dsRNA and global shape of RNA may play an important role in the specific reading mechanism of ADAR2.

  9. A-to-I RNA editing levels catalyzed by ADAR1 (show ADAR ELISA Kits) and ADARB1 decreased in Alzheimer's disease patients' brain tissues, mainly in the hippocampus and to a lesser degree in the temporal and frontal lobes.

  10. we conclude that this aberrant alternative splicing pattern of ADAR2 downregulates A-to-I editing in glioma

Mouse (Murine) Adenosine Deaminase, RNA-Specific, B1 (ADARB1) interaction partners

  1. ADARB1 mediates adenosine to inosine RNA editing in the testis, and these editing events are dispensable for male fertility in an inbred mouse strain in the lab.

  2. that ADAR2 is a mediator of injury-induced tactile allodynia and thus a potential therapeutic target for the treatment of neuropathic pain

  3. Results show that ADAR2 is important in site-specific changes of protein coding sequences but has relatively modest effects on gene expression and splicing in the adult mouse frontal cortex.

  4. Thus, Adarb1 and Adarb2 (show ADARB2 ELISA Kits) have nearly exclusive expression within brain tissue, while Adar (show ADAR ELISA Kits) has more appreciable expression across multiple tissues.

  5. After fear conditioning protocol, mRNA expression of ADAR2 increased in amygdala and hippocampus, and those mice had a learning-dependent increase in the alternatively spliced inactive form of ADAR2 in the amygdala.

  6. ADAR2 is a key factor for maintaining edited-miRNA population and balancing the expression of several essential miRNAs involved in cancer.

  7. This study clearly demonstrates that ADAR2 influences miRNA abundance and targeting at several levels in the mouse brain.

  8. chronically elevated intraocular pressure in adult mice reduces expression of the ADAR2 enzyme.

  9. Analysis of editing in the filamin A (show FLNA ELISA Kits) encoding mRNA shows very high editing levels outside the nervous system; further shows FLNA (show FLNA ELISA Kits) editing is mainly achieved by ADAR2 but that in some cases ADAR1 (show ADAR ELISA Kits) can efficiently compensate for ADAR2.

  10. Results suggest that ADAR2-reduction is associated with progressive deterioration of nuclear architecture, resulting in vacuolated nuclei due to a Ca2 (show CA2 ELISA Kits)+-permeable AMPA (show GRIA3 ELISA Kits) receptor-mediated mechanism

Zebrafish Adenosine Deaminase, RNA-Specific, B1 (ADARB1) interaction partners

  1. Adar2 Edits the Q/R site of AMPA (show GRIA3 ELISA Kits) receptor Subunit gria2alpha transcript to ensure normal development of nervous system and cranial neural crest cells

RED1 (ADARB1) Antigen Profile

Antigen Summary

This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region.

Gene names and symbols associated with ADARB1

  • adenosine deaminase, RNA specific B1 (ADARB1) antibody
  • adenosine deaminase, RNA-specific, B1 (adarb1) antibody
  • adenosine deaminase, RNA-specific, B1 L homeolog (adarb1.L) antibody
  • adenosine deaminase, RNA-specific, B1 (Adarb1) antibody
  • adenosine deaminase, RNA-specific, B1a (adarb1a) antibody
  • 1700057H01Rik antibody
  • adar2 antibody
  • adarb1 antibody
  • AW124433 antibody
  • AW558573 antibody
  • BB220382 antibody
  • D10Bwg0447e antibody
  • DRABA2 antibody
  • DRADA2 antibody
  • red1 antibody

Protein level used designations for ADARB1

adenosine deaminase, RNA-specific, B1 (RED1 homolog rat) , adenosine deaminase, RNA-specific, B1 (RED1 homolog) , adenosine deaminase, RNA-specific, B1 , RNA-specific adenosine deaminase B1 , double-stranded RNA-specific editase 1-like , RED1 homolog , RNA editase , RNA editing deaminase 1 , RNA-editing deaminase 1 , RNA-editing enzyme 1 , adenosine deaminase, RNA-specific, B1 (homolog of rat RED1) , double-stranded RNA-specific editase 1 , dsRNA adenosine deaminase DRADA2 , dsRNA adenosine deaminase , RNA editing deaminase of glutamate receptors , double-stranded RNA-specific editase

521761 Bos taurus
100124739 Xenopus (Silurana) tropicalis
100339367 Oryctolagus cuniculus
100483845 Ailuropoda melanoleuca
100589130 Nomascus leucogenys
495438 Xenopus laevis
374087 Gallus gallus
104 Homo sapiens
487809 Canis lupus familiaris
110532 Mus musculus
25367 Rattus norvegicus
58134 Danio rerio
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