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The protein encoded by ALDOA, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Additionally we are shipping ALDOA Antibodies (81) and ALDOA Proteins (27) and many more products for this protein.
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Overexpression of ALDOA is associated with colorectal cancer.
In vitro and in vivo results demonstrated that ALDOA was associated with proliferation and metastasis of pancreatic cancer cells.
Study shows that PI3K (show PIK3CA ELISA Kits) directly coordinates glycolysis with cytoskeletal dynamics in an AKT (show AKT1 ELISA Kits)-independent manner. Growth factors or insulin (show INS ELISA Kits) stimulate the PI3K (show PIK3CA ELISA Kits)-dependent activation of Rac (show AKT1 ELISA Kits), leading to disruption of the actin cytoskeleton, release of filamentous actin-bound aldolase (show ALD ELISA Kits) A, and an increase in aldolase (show ALD ELISA Kits) activity.
Our results expand the clinical spectrum of aldolase (show ALD ELISA Kits) A deficiency to isolated temperature-dependent rhabdomyolysis, and suggest that thermolability may be tissue specific. We also propose a treatment for this severe disease
Study provides evidence supporting a critical functional role of ALDOA in osteosarcoma progression, metastasis and perhaps chemoresistance.
ALDOC (show ALDOC ELISA Kits), Aldolase (show ALD ELISA Kits) A (ALDOA) and Aldolase B (show ALDOB ELISA Kits) (ALDOB (show ALDOB ELISA Kits)) activate Wnt (show WNT2 ELISA Kits) signaling.
ALDOA is highly expressed in lung squamous cell carcinoma (LSCC) and its expression level is correlated with LSCC metastasis, grades, differentiation status and poor prognosis.
The expression of ALDOA and/or SULT1A3 is significantly higher.
The results presented here point to ALDA as a factor involved in the regulation of cells proliferation.
The new prognostic biomarkers GRP78 (show HSPA5 ELISA Kits), Fructose-bisphosphate Aldolase A (ALDOA), Carbonic Anhydrase I (CA1 (show CA1 ELISA Kits)) and Peptidyl-prolyl cis-trans isomerase A (show PPIA ELISA Kits) or Cyclophilin A (PPIA (show PPIA ELISA Kits))) provided good survival prediction for TNM (show ODZ1 ELISA Kits) stage I-IV patients.
The lattice of muscle aldolase (show ALD ELISA Kits) contacts corresponded to an increased number of interactions between high-entropy side chains that mitigate the lattice strain incurred upon cryocooling and accompanying mosaic spread increases.
kinetic and structural analyses of fructose-bisphosphate aldolase (show FDA ELISA Kits)
Aldolase inhibits WASP/Arp2/3-dependent actin polymerization in vitro
The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10.
fructose-bisphosphate aldolase A
, aldolase A, fructose-bisphosphate
, aldolase C
, fructose-1,6-bisphosphate triosephosphate-lyase
, lung cancer antigen NY-LU-1
, muscle-type aldolase
, aldolase 1, A isoform