Aldolase B, Fructose-Bisphosphate Proteins (ALDOB)

Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Additionally we are shipping Aldolase B, Fructose-Bisphosphate Antibodies (93) and Aldolase B, Fructose-Bisphosphate Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALDOB 229 P05062
ALDOB 230163 Q91Y97
ALDOB 24190  
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Top Aldolase B, Fructose-Bisphosphate Proteins at antibodies-online.com

Showing 10 out of 22 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Escherichia coli (E. coli) Human GST tag 100 μg Log in to see 20 to 21 Days
$272.80
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
$229.85
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 20 Days
$785.40
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Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$319.00
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Yeast Rabbit His tag SDS-PAGE of protein expressed in E. coli. 500 μg Log in to see 60 to 71 Days
$962.50
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Escherichia coli (E. coli) Rabbit His-SUMO Tag   50 μg Log in to see 11 Days
$341.00
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Yeast Rabbit His tag   50 μg Log in to see 8 to 11 Days
$341.00
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details

ALDOB Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Aldolase B, Fructose-Bisphosphate (ALDOB) Interaction Partners

Human Aldolase B, Fructose-Bisphosphate (ALDOB) interaction partners

  1. Silencing Aldolase B activated epithelial markers and repressed mesenchymal markers, indicating inactivation of Aldolase B may lead to inhibition of epithelial-mesenchymal transition

  2. The downregulation of ALDOB could indicate a poor prognosis for HCC (show FAM126A Proteins) patients, and therefore, ALDOB might be considered a prognostic biomarker for HCC (show FAM126A Proteins), especially at the early stage.

  3. ALDOC (show ALDOC Proteins), Aldolase A (ALDOA (show ALDOA Proteins)) and Aldolase B (ALDOB) activate Wnt (show WNT2 Proteins) signaling.

  4. Single nucleotide polymorphisms in ALDOB, MAP3K1 (show MAP3K1 Proteins), and MEF2C (show MEF2C Proteins) are associated with cataract.

  5. both of exogenous and endogenous ALDOB proteins bind to hepatitis B surface antigen and colocalize in the cytoplasm in vitro and inhibit apoptosis of cisplatin-induced HepG2 cells.

  6. Efficient inhibition of aldolase B can prevent high glucose-induced overproduction of methylglyoxal and related cellular dysfunction in endothelial cells.

  7. Aldolase B with the A149P substitution has activity that is <100-fold that of the wild type.

  8. These novel mutations in ALDOB represent 2% of alleles in American HFI (hereditary fructose intolerance) patients, with IVS1+1G>C representing a significantly higher allele frequency (6%) among HFI patients of Hispanic and African-American ethnicity.

  9. This is the first report of six unrelated patients sharing the same ALDOB deletion, thus indicating a founder effect for this allele.

  10. Biochemical study of defective aldolase B enzymes is key to revealing the molecular basis of the disease and providing a stronger basis for improved treatment and diagnosis

Mouse (Murine) Aldolase B, Fructose-Bisphosphate (ALDOB) interaction partners

  1. characterization of the aldolase B gene enhancer

  2. NKCC2 (show SLC12A1 Proteins) surface expression in mammalian cells is shown to be downregulated by a novel interaction with aldolase B

Aldolase B, Fructose-Bisphosphate (ALDOB) Protein Profile

Protein Summary

Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.

Gene names and symbols associated with ALDOB

  • aldolase B (xaldb)
  • aldolase, fructose-bisphosphate B (aldob)
  • aldolase, fructose-bisphosphate B S homeolog (aldob.S)
  • aldolase, fructose-bisphosphate B (ALDOB)
  • aldolase b, fructose-bisphosphate (aldob)
  • aldolase B, fructose-bisphosphate (Aldob)
  • aldolase, fructose-bisphosphate B (Aldob)
  • ALDB protein
  • Aldo-2 protein
  • Aldo2 protein
  • aldob protein
  • BC016435 protein
  • fb25f09 protein
  • LIV10 protein
  • wu:fb25f09 protein
  • xaldb protein

Protein level used designations for ALDOB

aldolase B, fructose-bisphosphate , Fructose-bisphosphate aldolase B , fructose-bisphosphate aldolase B-like , aldolase 2 , aldolase B, fructose-bisphosphatase , fructose-bisphosphate aldolase B , liver-type aldolase , fructose 1,6, bisphosphate aldolase , aldolase 2, B isoform , Aldolase B fructose-biphosphate , Aldolase B, fructose-biphosphate

GENE ID SPECIES
379254 Xenopus laevis
394736 Xenopus (Silurana) tropicalis
398623 Xenopus laevis
464623 Pan troglodytes
474787 Canis lupus familiaris
100136522 Salmo salar
100390438 Callithrix jacchus
713818 Macaca mulatta
100054480 Equus caballus
100599436 Nomascus leucogenys
229 Homo sapiens
515263 Bos taurus
100328925 Oryctolagus cuniculus
230163 Mus musculus
24190 Rattus norvegicus
321664 Danio rerio
427308 Gallus gallus
443440 Ovis aries
100174217 Pongo abelii
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