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Aminoadipate Aminotransferase Proteins (AADAT)

AADAT encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. Additionally we are shipping AADAT Antibodies (76) and AADAT Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
AADAT 51166 Q8N5Z0
AADAT 23923 Q9WVM8
AADAT 29416 Q64602
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Top AADAT Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,094.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,094.67
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 to 8 Days
$488.25
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

AADAT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Aminoadipate Aminotransferase (AADAT) Interaction Partners

Human Aminoadipate Aminotransferase (AADAT) interaction partners

  1. association of SNP AADAT+401C/T with the host immune response to bacterial meningitis, suggesting that this SNP may affect the host ability in recruitment of leukocytes to the infection site

  2. analysis of the crystal structure of kynurenine aminotransferase II

  3. analysis of the crystal structure of human kynurenine aminotransferase II

  4. A human cDNA encodes a 425-residue protein with a mitochondrial cleavage signal and a pyridoxal-phosphate binding site, ~70% identical to the mouse and rat AADAT orthologs. Bacterial expression studies confirm that the gene encodes AADAT activity.

Mouse (Murine) Aminoadipate Aminotransferase (AADAT) interaction partners

  1. human KAT (show NEK1 Proteins) III/CCBL2 (show CCBL2 Proteins) possesses cysteine S-conjugate beta-lyase (show CCBL1 Proteins) activity, as does mouse KAT (show NEK1 Proteins) II

  2. This study showed that KAT (show NEK1 Proteins) II KO mice show the expected decrease in extracellular kynurenic acid levels, and that this reduction is accompanied by a significant increase in extracellular glutamate (show GRIN1 Proteins).

  3. The activity of mouse KAT (show NEK1 Proteins) II was not significantly inhibited by any proteinogenic amino acids at equimolar concentrations and half-life was 27.4 minutes at 65 degree C.

  4. Alpha7* nAChR (show CHRNA7 Proteins) and NMDA receptor functions were studied in kynurenine aminotransferase II null mice(mKat-2-/- mice). At 21 postnatal days, mKat-2-/- mice had lower hippocampal kynurenic acid levels and more spontaneous locomotor activity than control mice

  5. Results show that gene targeting of kynurenine aminotransferase II (KAT (show NEK1 Proteins)) in mice leads to early and transitory decreases in brain KAT (show NEK1 Proteins) activity and kynurenic acid levels with commensurate behavioral and neuropathological changes.

AADAT Protein Profile

Protein Summary

This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Two alternative transcripts encoding the same isoform have been identified, however, additional alternative transcripts and isoforms may exist.

Gene names and symbols associated with AADAT

  • aminoadipate aminotransferase (aadat)
  • aminoadipate aminotransferase (AADAT)
  • aminoadipate aminotransferase (Aadat)
  • kynurenine/alpha-aminoadipate aminotransferase, mitochondrial-like (LOC520638)
  • AADAT protein
  • Aadt protein
  • AI875679 protein
  • Kat2 protein
  • KATII protein
  • MGC80030 protein
  • mKat-2 protein

Protein level used designations for AADAT

aminoadipate aminotransferase , alpha-aminoadipate aminotransferase , kynurenine/alpha-aminoadipate aminotransferase, mitochondrial-like , 2-aminoadipate aminotransferase , 2-aminoadipate transaminase , KAT/AadAT , L kynurenine/alpha aminoadipate aminotransferase , kynurenine aminotransferase II , kynurenine--oxoglutarate aminotransferase II , kynurenine--oxoglutarate transaminase 2 , kynurenine--oxoglutarate transaminase II , kynurenine/alpha-aminoadipate aminotransferase, mitochondrial , kynurenine aminotransferase 2

GENE ID SPECIES
432067 Xenopus laevis
461601 Pan troglodytes
496662 Xenopus (Silurana) tropicalis
100435746 Pongo abelii
51166 Homo sapiens
428728 Gallus gallus
486059 Canis lupus familiaris
23923 Mus musculus
29416 Rattus norvegicus
508929 Bos taurus
520638 Bos taurus
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