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APPBP2 encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. Additionally we are shipping Amyloid beta Precursor Protein (Cytoplasmic Tail) Binding Protein 2 Antibodies (103) and Amyloid beta Precursor Protein (Cytoplasmic Tail) Binding Protein 2 Kits (7) and many more products for this protein.
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A mechanism through which amino acids may suppress the expression of PAT1 on lysosomes by inducing protein cleavage to remove a targeting signal.
Data indicate that the glycosylation-deficient mutant of amino acid transporter PAT1 (PAT1(3)(NQ) ) is unstable and is degraded mainly via the endoplasmic reticulum-associated degradation pathway in HEK293 cells.
It facilitates the regulator of calcineurin 1 (show RCAN1 Proteins)-mediated apoptosis by downregulating proteasome subunits.
Sertraline is an apparent non-competitive inhibitor of PAT1-mediated transport.
Data suggest that PAT1 in enterocytes is responsible for intestinal absorption of some of the alkaloids from areca nut (i.e., arecaidine, guvacine, isoguvacine).
estrogen attenuates the activity of PAT1 by directly closing PAT1
In hPAT1 expressing oocytes Gly-Tyr (show TYR Proteins), Gly-Pro, and Gly-Phe inhibited currents induced by drug substances.
In human cells, SLC36A1 localized on intracellular membranes is required for amino acid-dependent mTORC1 activation and cell proliferation. SLC36A1 also has similar in vivo growth regulatory activity to fly SLC36 AAAPs when expressed in Drosophila.
PAT1 expressed exclusively in apical membrane of Caco-2 cells. hPAT1 may be responsible for H(+)-coupled amino acid transport expressed in apical membrane of Caco-2 cells.
Amino acid uptake via hPAT1 is inhibited by activators of the cAMP pathway indirectly through inhibition of NHE3 (show SLC9A3 Proteins) activity.
This gene encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1.
amyloid protein-binding protein 2
, amyloid beta precursor protein (cytoplasmic tail) binding protein 2
, amyloid beta precursor protein-binding protein 2
, amyloid beta precursor protein-binding protein 2-like
, amyloid protein-binding protein 2-like
, protein interacting with APP tail 1
, lysosomal amino acid transporter 1
, proton-coupled amino acid transporter 1
, proton/amino acid transporter 1
, solute carrier family 36 member 1