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Angiopoietin-Like 4 Proteins (ANGPTL4)

ANGPTL4 is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. Additionally we are shipping ANGPTL4 Antibodies (152) and ANGPTL4 Kits (55) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ANGPTL4 57875 Q9Z1P8
ANGPTL4 51129 Q9BY76
ANGPTL4 362850 Q6TMA8
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Top ANGPTL4 Proteins at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 2 to 3 Days
$275.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_COS-7 Cells Mouse DYKDDDDK Tag   10 μg Log in to see 5 to 8 Days
$225.75
Details
HOST_Escherichia coli (E. coli) Human GST tag Angiopoietin-Like 4 (ANGPTL4) (AA 28-403), (partial) protein (GST tag) 50 μg Log in to see 9 to 11 Days
$242.00
Details
HOST_Human Human DYKDDDDK Tag   10 μg Log in to see 5 to 8 Days
$299.25
Details
HOST_Human Mouse DYKDDDDK Tag   10 μg Log in to see 5 to 8 Days
$299.25
Details
HOST_Human Rat DYKDDDDK Tag   10 μg Log in to see 5 to 8 Days
$299.25
Details
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
$827.20
Details

ANGPTL4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) , , ,
, ,
Human , , , , , , ,
, , , ,
Rat (Rattus) , ,
, ,

Top referenced ANGPTL4 Proteins

  1. Human ANGPTL4 Protein expressed in HEK-293 Cells - ABIN2180590 : Nam, Yoon, Park: A novel fabrication method of macroporous biodegradable polymer scaffolds using gas foaming salt as a porogen additive. in Journal of biomedical materials research 2000 (PubMed)
    Show all 4 references for ABIN2180590

  2. Human ANGPTL4 Protein expressed in Wheat germ - ABIN1345057 : Basak, Duttaroy: cis-9,trans-11 conjugated linoleic acid stimulates expression of angiopoietin like-4 in the placental extravillous trophoblast cells. in Biochimica et biophysica acta 2013 (PubMed)
    Show all 2 references for ABIN1345057

More Proteins for Angiopoietin-Like 4 (ANGPTL4) Interaction Partners

Cow (Bovine) Angiopoietin-Like 4 (ANGPTL4) interaction partners

  1. increase in angiopoietin-like protein 4 messenger RNA across multiple models of altered energy balance identifies it as an adipokine that is uniquely responsive to changes in energy balance in the lactating dairy cow

  2. These findings indicate that liver and adipose tissue are key sources of ANGPTL4 in cattle; the protein was also highly abundant in ruminal epithelium, making it possible that commensal microbes may influence ANGPTL4 synthesis and secretion.

Mouse (Murine) Angiopoietin-Like 4 (ANGPTL4) interaction partners

  1. ANGPTL4 is part of a shuttling mechanism that directs fatty acids derived from circulating triglyceride-rich lipoproteins to brown adipose tissue during cold.

  2. This model suggests a general mechanism by which TAG trafficking is coordinated by lipasin, Angptl3 (show ANGPTL3 Proteins) and Angptl4 at different nutritional statuses.

  3. These results reveal that FTO (show FTO Proteins) regulates fatty acid mobilization in adipocytes and thus body weight in part through posttranscriptional regulation of Angptl4.

  4. these results suggest that IL-1beta (show IL1B Proteins) increases Angptl4 expression through a mechanism dependent on the JNK (show MAPK8 Proteins)-MAPK (show MAPK1 Proteins) signaling pathway in MC3T3-E1 cells.

  5. glucagon receptor (show GCGR Proteins) antagonist improves glycemia in diet-induced obese angptl4 knockout mice without increasing glucagon (show GCG Proteins) levels or alpha-cell proliferation, underscoring the importance of this protein.

  6. Angptl4 may play a role in osteoblastic differentiation, and possibly angiogenesis via regulation of VEGF

  7. silencing angiopoietin-like protein 4 protects against LPS (show TLR4 Proteins)-induced acute lung injury via regulating SIRT1 (show SIRT1 Proteins)/NF-kB signaling pathway

  8. This study showed that phloridzin improved plasma lipoprotein lipase (show LPL Proteins) activity via a decrease of ANGPTL4 mRNA expression and an increase of AMP-activated protein kinase (show PRKAA2 Proteins) phosphorylation.

  9. Letter: Angiopoietin-like 4 is induced during sebocyte differentiation and regulates sebaceous lipogenesis in vitro but is dispensable for sebaceous gland function in vivo.

  10. GR and FoxO1 (show FOXO1 Proteins) are required for Angptl4 transcription activation, and that FoxO1 (show FOXO1 Proteins) negatively mediates the suppressive effect of insulin (show INS Proteins)

Human Angiopoietin-Like 4 (ANGPTL4) interaction partners

  1. ANGPTL4 mRNA expressions and serum levels were significantly higher in high grade breast carcinoma.

  2. Knockdown of ANGPTL4 inhibits proliferation and promotes apoptosis in cervical cancer.

  3. ANGPTL4 levels were higher in both obese and non-obese PCOS patients compared to healthy controls.

  4. circulating ANGPTL4 levels are up-regulated in COPD (show ARCN1 Proteins) patients, and have correlations with pulmonary function and systematic inflammation in COPD (show ARCN1 Proteins)

  5. Collectively, our findings indicate that miR (show MLXIP Proteins)-134 may regulate lipid accumulation and proinfiammatory cytokine secretion in macrophages by targeting the ANGPTL4 gene.

  6. This study is the first to show that podocyte-secreted Angptl4 is upregulated in diabetic neuropathy and can be detected in urine.

  7. Data suggest that up-regulation of plasma levels of Angptl4 (angiopoietin-like 4 protein) and LPL (lipoprotein lipase (show LPL Proteins)) can be used as biomarkers specific to detecting the stage of diabetic cardiovascular complications.

  8. Hepatocellular carcinoma (HCC (show FAM126A Proteins)) tissues expressed significantly lower levels of ANGPTL4 mRNA than non-tumor tissues; copy number of ANGPTL4 gene in tumor tissues was significantly lower than in non-tumor tissues of HCC (show FAM126A Proteins) patients. Higher frequency of methylation of CpG sites of ANGPTL4 promoter was detected in tumor tissues compared to non-tumor tissues.

  9. results demonstrate ANGPTL4 contributes to OSCC metastasis by stimulating cell invasion. ANGPTL4 is potential therapeutic target for preventing cancer metastasis.

  10. Carriers of E40K and other inactivating mutations in ANGPTL4 had lower levels of triglycerides and a lower risk of coronary artery disease than did noncarriers.

Pig (Porcine) Angiopoietin-Like 4 (ANGPTL4) interaction partners

  1. The ANGPTL4 G/A polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) showed a significant effect on intramuscular fat

Zebrafish Angiopoietin-Like 4 (ANGPTL4) interaction partners

  1. These results suggest that the microbiota might regulate host intestinal Angptl4 protein expression and peripheral fat storage by suppressing the activity of an intestine-specific transcriptional enhancer.

ANGPTL4 Protein Profile

Protein Summary

This gene is a member of the angiopoietin/angiopoietin-like gene family and encodes a glycosylated, secreted protein with a fibrinogen C-terminal domain. This gene is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. The encoded protein is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. The encoded protein may play a role in several cancers and it also has been shown to prevent the metastatic process by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. This gene was previously referred to as ANGPTL2 but has been renamed ANGPTL4.

Gene names and symbols associated with Angiopoietin-Like 4 Proteins (ANGPTL4)

  • angiopoietin-like 4 (ANGPTL4)
  • Angiopoietin-related protein 4 (angl4)
  • angiopoietin 4 (ANGPT4)
  • angiopoietin-like 4 (Angptl4)
  • angiopoietin-like 4 (angptl4)
  • ANGPTL2 protein
  • ANGPTL4 protein
  • ARP4 protein
  • Bk89 protein
  • fiaf protein
  • HFARP protein
  • im:7144703 protein
  • Ng27 protein
  • NL2 protein
  • PGAR protein
  • Pgarg protein
  • pp1158 protein
  • si:rp71-39b20.7 protein

Protein level used designations for Angiopoietin-Like 4 Proteins (ANGPTL4)

angiopoietin-like 4 , Angiopoietin-related protein 4 , angiopoietin-related protein 4-like , ANG-4 , angiopoietin-4 , angiopoietin-like protein 4 , 425O18-1 , angiopoietin-related protein 4 , fasting-induced adipose factor , fibrinogen/angiopoietin-related protein , hepatic fibrinogen/angiopoietin-related protein , major histocompatibility complex region NG27 , secreted protein Bk89 , PPARG angiopoietin related protein , hepatic angiopoietin-related protein , peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin-related protein , HFARP , PPARG angiopoietin-related protein , angiopoietin-like secreted glycoprotein 4 , angiopoietin-like 4 protein

GENE ID SPECIES
476724 Canis lupus familiaris
743667 Pan troglodytes
769087 Gallus gallus
100194912 Salmo salar
100415086 Callithrix jacchus
100438448 Pongo abelii
617915 Bos taurus
57875 Mus musculus
51129 Homo sapiens
362850 Rattus norvegicus
397628 Sus scrofa
509963 Bos taurus
100860916 Capra hircus
492647 Danio rerio
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