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Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. Additionally we are shipping Angiostatin Kits (43) and Angiostatin Antibodies (12) and many more products for this protein.
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Plasminogen (show PLG Proteins)-deficient mice frequently develop colon lesions and rectal prolapses.
manganese transport protein (show SLC11A2 Proteins) C (show PROC Proteins) (MntC) is an extracellular matrix- and plasminogen-binding protein (show ENO1 Proteins)
Plg (show PLG Proteins) from mouse plasma contains oxPtdPC adducts that are not affected by the action of Lp-PLA(2 (show Lp-PLA2 Proteins)), suggesting that linkage to Plg (show PLG Proteins) protects oxPtdPCs from metabolism during their transport in the plasma.
plg (show PLG Proteins)-/- and tPA (show PLAT Proteins)-/- mice exhibit brain parenchymal fibrin deposits that appear to result from reduced neurovascular integrity
plasminogen (show PLG Proteins)-dependent proteolysis has a beneficial effect during neurological recovery after stroke.
Pla-induced mononuclear cell recruitment in vivo was dependent on protease-activated receptor-1 activation of the MEK/ERK/NF-kappaB pathway, which led to the release of CCL2 and activation of CCR2.
Plg (show PLG Proteins) may play an important role in innate immunity by changing expression of genes that contribute to phagocytosis.
Plasminogen (show PLG Proteins) is a key molecular determinant of inflammatory joint disease capable of simultaneously driving or ameliorating arthritis pathogenesis in distinct anatomic locations in the same subject.
Plasmin (show PLG Proteins) suppresses brain metastasis in two ways: by converting membrane-bound astrocytic FasL (show FASL Proteins) into a paracrine death signal for cancer cells, and by inactivating the axon pathfinding molecule L1CAM (show L1CAM Proteins), which metastatic cells express for spreading along brain capillaries and for metastatic outgrowth.
Plasminogen (show PLG Proteins) stimulates autocrine cytokine production in human airway smooth muscle cells in a manner mediated by plasmin (show PLG Proteins) and annexin A2 (show ANXA2 Proteins).
Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo. Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells (By similarity).
, plasmin heavy chain A
, plasmin light chain B