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AGTRAP encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. Additionally we are shipping Angiotensin II Receptor-Associated Protein Antibodies (48) and Angiotensin II Receptor-Associated Protein Kits (3) and many more products for this protein.
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A role for AT1 receptor-associated proteins in blood pressure regulation
ATRAP, a directly interacting and functionally inhibiting molecule of AT1R (show AGTR1 Proteins), plays a protective role against the development of systemic insulin (show INS Proteins) resistance via regulatory effects on adipose tissue function.
The phosphatidylinositol transfer protein (show PITPNA Proteins) RdgBbeta (show PITPNC1 Proteins) binds 14-3-3 (show YWHAQ Proteins) via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein).
the GG genotype of the AGTRAP rs11121816 T/G single nucleotide polymorphism was associated with increased mortality in two cohorts of patients who had septic shock.
CSF (show CSF2 Proteins) angiotensin II, ACE (show ACE Proteins), and ACE2 (show ACE2 Proteins) levels are decreased in neuromyelitis optica/NMO spectrum disorder patients with anti-AQP4 (show AQP4 Proteins) antibody, reflecting severe destruction of perivascular astrocytes
Small interfering RNA significantly attenuates angiotensin II type 1 receptor (show AGTR1 Proteins)-stimulated inositol phosphate formation.
cloned a new human gene cDNA that codes for a homolog of the murine Agtrap protein
isolation of a novel protein, ARAP1 (show ARAP1 Proteins), which promotes recycling of angiotensin(1A) to the plasma membrane in HEK (show EPHA3 Proteins)-293 cells
CAML (show CAMLG Proteins) is an important signal transducer for the actions of Ang II (show AGT Proteins) in regulating the calcineurin (show PPP3CA Proteins)-NFAT (show NFATC1 Proteins) pathway and the interaction of CAML (show CAMLG Proteins) with ATRAP may mediate the Ang II (show AGT Proteins) actions in vascular physiology
These results suggest that increased formation of AT1R-P2Y6R (show P2RY6 Proteins) heterodimers with age may increase the likelihood of hypertension induced by Ang II (show AGT Proteins).
although erythropoiesis and blood pressure are negatively controlled through the AT1 receptor inhibition in vivo, the pathways involved are complex and distinct
Distal tubule-dominant enhancement of ATRAP inhibits pathological renal sodium reabsorption and blood pressure elevation in response to high salt loading.
AT1R knockout mice were less vulnerable to controlled cortical impact-induced injury.
The inhibition of degradation of angiotensin II type 1 receptor (show AGTR1 Proteins)-associated protein (show BCAP31 Proteins) (ATRAP) and inactivation of AT1R-mediated p38 MAPK (show MAPK14 Proteins) and STAT3 (show STAT3 Proteins) signaling pathways, are involved cardiac hypertrophy.
Activation of aortic vascular ATRAP partially inhibits the Nox4 (show NOX4 Proteins)/p22(phox (show CYBA Proteins))-ROS (show ROS1 Proteins)-p38MAPK (show MAPK14 Proteins)/JNK (show MAPK8 Proteins) pathway and pathological aortic hypertrophy provoked by Ang II (show AGT Proteins)-mediated hypertension.
ATRAP, a directly interacting and functionally inhibiting molecule of AT1R, plays a protective role against the development of systemic insulin (show INS Proteins) resistance via regulatory effects on adipose tissue function.
AGTRAP expression is regulated by USF1 (show USF1 Proteins) and USF2 (show USF2 Proteins)
renal tubule-dominant ATRAP activation provokes no evident effects on blood pressure at baseline but exerts an inhibitory effect on the pathological elevation of blood pressure in response to angiotensin II stimulation
These data imply an involvement of AT1R in fetal development and of AT2R (show AGTR2 Proteins) in adult function.
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.
angiotensin II receptor-associated protein
, type-1 angiotensin II receptor-associated protein
, Type-1 angiotensin II receptor-associated protein
, AT1 receptor-associated protein
, ATI receptor-associated protein
, angiotensin II, type I receptor-associated protein
, AT1 receptor
, angiotensin II receptor, type I