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ASB9 encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family. Additionally we are shipping ASB9 Antibodies (39) and ASB9 Kits (11) and many more products for this protein.
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Molecular docking yielded a structural model consistent with all of the data that suggested the N-terminal residues of ASB9(1-252) may lie in one CK active site. This model was corroborated by enzymatic activity assays and mutational analysis.
ASB9 is unstable alone but forms a stable ternary complex with EloBC that binds with high affinity to the Cullin 5 (show CUL5 Proteins) N-terminal domain.
His103 and Phe107 in hASB9-2 are essential for binding to CKB (show CHKB Proteins).
The results of the present study suggest that ASB9 is a useful prognostic marker for colorectal cancer
ASB9 interacts with the creatine kinase system and negatively regulates cell growth.
The purified ASB9-2 protein, the splice variant of ASB9 with only one ankyrin repeat domain, was crystallized and diffracted to 2.2A resolution.
creatine kinase B (CKB (show CKB Proteins)) interacts with Asb-9 in a specific, SOCS (show CISH Proteins) box-independent manner
This gene encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family. Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further complex with the cullin and ring box proteins to form E3 ubiquitin ligase complexes. They may function to mediate the substrate-recognition of the E3 ubiquitin ligases. A transcribed pseudogene of this gene has been identified on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene.
ankyrin repeat and SOCS box protein 9
, ankyrin repeat and SOCS box-containing 9-like
, ankyrin repeat and SOCS box-containing protein 9
, ankyrin repeat and SOCS box-containing 9
, ankyrin repeat and suppressor of cytokine signaling box protein 9