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ASB2 encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. Additionally we are shipping ASB2 Kits (11) and ASB2 Proteins (4) and many more products for this protein.
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Using ASB2 conditional knockout mice.
Phosphorylation of serine 323 of ASB2 alpha by Erk (show EPHB2 Antibodies) kinases is critical for ASB2alpha-mediated degradation of FLNA (show FLNA Antibodies).
data therefore reveal ubiquitin acceptor sites in FLNa (show FLNA Antibodies) and establish that ASB2alpha-mediated effects on cell spreading are due to loss of filamins.
Data show that neither endogenous nor exogenously expressed ASB2alpha induces degradation of JAK (show JAK3 Antibodies) proteins in hematopoietic cells
A model whereby ASB2 contributes to hematopoietic differentiation, in part, through MLL (show MLL Antibodies) degradation and HOX (show MSH2 Antibodies) gene down-regulation.
By shifting monomeric E3 ligase complexes to dimeric forms through activation of Asb2 transcription, Notch (show NOTCH1 Antibodies) could effectively control the turnover of a variety of substrates and it exerts diverse effects on cell proliferation and differentiation.
ASB2 may regulate hematopoietic cell differentiation by modulating cell spreading and actin remodeling through targeting of filamins A and B for degradation.
This study identifies desmin (show DES Antibodies) as a new Asb2b target for proteasomal degradation in cardiomyocytes and suggests that accumulation of desmin (show DES Antibodies) could contribute to UPS impairment in Hypertrophic cardiomyopathy mice and patients
ASB2(-/-) immature dendritic cells exhibit reduced matrix-degrading function leading to defective migration.
ASB2beta is part of an active E3 ubiquitin ligase (show MUL1 Antibodies) complex and targets the actin-binding protein (show PFN1 Antibodies) filamin B (show FLNB Antibodies) for proteasomal degradation.
This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
ankyrin repeat and SOCS box-containing 2
, ankyrin repeat and SOCS box protein 2-like
, ankyrin repeat and SOCS box protein 2
, ankyrin repeat and SOCS box-containing protein 2a
, ankyrin repeat and SOCS box-containing protein 2
, ankyrin repeat-containing SOCS box protein 2