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Acts as a calcium-activated chloride channel. Additionally we are shipping ANO1 Antibodies (317) and ANO1 Kits (1) and many more products for this protein.
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DOG1 positivity might be a candidate marker to support KIT and PDGFRA (show PDGFRA Proteins) mutations.
Results showed that DOG1 expression was consistently positive in breast myoepithelial cells (MEC (show CCL28 Proteins)), and is then a useful MEC (show CCL28 Proteins) marker providing more sophisticated information when diagnosing uncertain cases in the breast.
ANO1 on ICCs makes a key contribution to generation and regulation of pacemaker electrical slow-wave activity.
Data show that calcium-activated chloride channel TMEM16 overexpression correlates with decreased survival in human papilloma virus -negative tumors.
DOG1 was expressed in 66% of CD117(+) GISTs and highly associated with tumor size and the rate of wild-type tumors
DOG1 positivity in select non-GIST tumors.
Our results indicated that both the electrical property and the size of the side-chain at residue 447 have significant effects on Ca(2 (show CA2 Proteins)+) dependent gating of TMEM16A.
ANO1 expression and gene amplification showed no significant associations with clinicopathological parameters in HNSCC.
DOG1 is a sensitive marker in the diagnosis of acinic cell carcinoma
TCGA analysis showed that ANO1 and FADD, located at 11q13, were co-expressed at transcript level and significantly associated with overall and disease-free survival
Data indicate that anoctamin channel proteins ANO1 and ANO2 (show ANO2 Proteins) are expressed in the cerebellum.
Ano1 may play a role in the pathophysiological processes during ischaemia in heart, and therefore, Ano1 might be a potential therapeutic target to prevent ischaemic damage
Thegenetic ablation of TMEM16A did not seem to affect the maturation of olfactory sensory neurons and their ciliary layer.
Suggest Ca(2 (show CA2 Proteins)+)-dependent push-pull conformational change as a key electromechanical movement for gating the ANO1 channel.
These results indicate ANO1 channels are involved with TRPV1 (show TRPV1 Proteins) actions in sensory neurons and inhibition of ANO1 could be a novel means of inducing analgesia.
Basolateral Ano1 supports CCH-induced Ca2 (show CA2 Proteins)+ signaling and secretion via luminal CFTR (show CFTR Proteins).
By inhibiting TRPM7 (show TRPM7 Proteins) and ANO1 via opioid receptor signaling pathways.
TMEM16A is an essential component of Ca(2 (show CA2 Proteins)+)-activated Cl(-) currents in mouse vomeronasal sensory neurons.
conclude that ANO1 encodes Ca(2 (show CA2 Proteins)+)-activated chloride (Cl(-)) channel and plays a significant role in the phase 1 repolarization of action potentials
TMEM16A and myocardin form a positive feedback loop that is disrupted by KLF5 (show KLF5 Proteins) during Ang II (show AGT Proteins)-induced vascular remodeling.
Acts as a calcium-activated chloride channel. Required for normal tracheal development (By similarity).
anoctamin 1, calcium activated chloride channel
, Ca-activated chloride channel Tmem16A
, discovered on gastrointestinal stromal tumors protein 1
, oral cancer overexpressed 2
, transmembrane protein 16A (eight membrane-spanning domains)
, tumor-amplified and overexpressed sequence 2
, transmembrane protein 16A