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Apoptosis-Inducing, TAF9-Like Domain 1 Proteins (APITD1)

APITD1 was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. Additionally we are shipping Apoptosis-Inducing, TAF9-Like Domain 1 Antibodies (25) and Apoptosis-Inducing, TAF9-Like Domain 1 Kits (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
APITD1 378708 Q8N2Z9
APITD1 69928 Q9D084
APITD1 613732 Q2TBR7
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Top Apoptosis-Inducing, TAF9-Like Domain 1 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,284.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,293.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

APITD1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Cow (Bovine)

More Proteins for Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1) Interaction Partners

Human Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1) interaction partners

  1. The MHF complex, which is a heterotetramer that comprises two MHF1-MHF2 heterodimers, is remodeled by FANCM to favor recognition of branched DNA over dsDNA.

  2. CENP-S is not found in a soluble complex with its binding partner CENP-T (show CENPT Proteins) but it interacts strongly and specifically with immobilized CENP-T (show CENPT Proteins) in an in vivo binding assay.

  3. It discusses current knowledge of the biological roles of CENP-S and CENP-X (show BHLHE40 Proteins) and how their dual existence may be a common feature of CCAN (constitutive centromere-associated network) proteins.

  4. A long, positively charged patch exposed on the surface of the (MHF1-MHF2) complex plays a critical role in double-stranded DNA binding to chromatin.

  5. MHF1 and MHF2 form a compact tetramer to which FANCM-F binds through a 'dual-V' shaped structure.

  6. provide biochemical evidence that MHF1 and MHF2 assemble into a heterodimer that binds DNA and enhances the DNA branch migration activity of FANCM.

  7. Mutations in APITD1 is not a common abnormality of neuroblastoma (show ARHGEF16 Proteins) tumours.

  8. These results indicate that APITD1 is not the tumor suppressor gene on 1p36 responsible for the negative prognostic effect in uveal melanoma with concurrent loss of chromosome arm 1p, region 36, and chromosome 3.

  9. Results identified a centromere protein S (CENP-S)-containing subcomplex that includes the new constitutive kinetochore protein CENP-X (show BHLHE40 Proteins).

Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1) Protein Profile

Protein Summary

This gene was identified in the neuroblastoma tumor suppressor candidate region on chromosome 1p36. It contains a TFIID-31 domain, similar to that found in TATA box-binding protein-associated factor, TAF(II)31, which is required for p53-mediated transcription activation. This gene was expressed at very low levels in neuroblastoma tumors, and was shown to reduce cell growth in neuroblastoma cells, suggesting that it may have a role in a cell death pathway. The protein is a component of multiple complexes, including the Fanconi anemia (FA) core complex, the APITD1/CENPS complex, and the CENPA-CAD (nucleosome distal) complex. Known functions include an involvement with chromatin associations of the FA core complex, and a role in the stable assembly of the outer kinetochore. Alternative splicing of this gene results in multiple transcript variants. Naturally occurring read-through transcripts also exist between this gene and the downstream cortistatin (CORT) gene, as represented in GeneID:100526739. An APITD1-related pseudogene has been identified on chromosome 7.

Gene names and symbols associated with APITD1

  • apoptosis-inducing, TAF9-like domain 1 (APITD1)
  • apoptosis-inducing, TAF9-like domain 1 (Apitd1)
  • apoptosis-inducing, TAF9-like domain 1 (apitd1)
  • 2610040C18Rik protein
  • 2810407L01Rik protein
  • CENP-S protein
  • cenps protein
  • FAAP16 protein
  • mhf1 protein

Protein level used designations for APITD1

FANCM-interacting histone fold protein 1 , Fanconi anemia-associated polypeptide of 16 kDa , apoptosis-inducing TAF9-like domain-containing protein 1 , centromere protein S , apoptosis-inducing TAF9-like domain-containing protein 1 homolog , ortholog of human apoptosis-inducing, TAF9-like domain 1 APITD1 , CENP-S

GENE ID SPECIES
378708 Homo sapiens
69928 Mus musculus
613732 Bos taurus
431958 Xenopus laevis
101114968 Ovis aries
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