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Arachidonate 12-Lipoxygenase, 12R Type Proteins (ALOX12B)

ALOX12B encodes an enzyme involved in the converstion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Additionally we are shipping ALOX12B Antibodies (24) and ALOX12B Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALOX12B 242 O75342
ALOX12B 11686 O70582
ALOX12B 287425 Q2KMM4
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Top ALOX12B Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$246.96
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,042.50
Details

ALOX12B Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Arachidonate 12-Lipoxygenase, 12R Type (ALOX12B) Interaction Partners

Human Arachidonate 12-Lipoxygenase, 12R Type (ALOX12B) interaction partners

  1. We found that the contribution of the ALOX12B gene to the pathogenesis of Autosomal Recessive Congenital Ichthyosis (show LBR Proteins) to be as important as that of TGM1 (show TGM1 Proteins) in families of Arab Muslim origin

  2. Loss-of-function mutations in the LOX (show LOX Proteins) genes ALOX12B and ALOXE3 (show ALOXE3 Proteins) have been found to represent the second most common cause of autosomal recessive congenital ichthyosis (show LBR Proteins). [review]

  3. This review covers the background to discovery of the two key lipoxygenases (LOX (show LOX Proteins)) involved in epidermal barrier function, 12R-LOX and eLOX3 (show ALOXE3 Proteins). [review]

  4. Autosomal recessive congenital ichthyosis (show LBR Proteins) patients with NIPAL4 (show NIPAL4 Proteins) mutations and abnormal ichthyin (show NIPAL4 Proteins) expression showed increased 12R-LOX and eLOX-3 (show ALOXE3 Proteins) staining and a colocalization signal of these LOXs that was three times the normal intensity.

  5. It was shown that 12R-lipoxygenase is involved in MUC5AC expression via ERK (show EPHB2 Proteins)- and Sp1 (show PSG1 Proteins)-signalling pathways.

  6. co-overproduction of the two chaperones with 12R-LOX resulted in increased solubility of 12R-LOX and allowed the purification of milligram amounts of active enzyme for structural studies by X-ray diffraction

  7. ALOX12B mutations are the leading cause of self-improving collodion ichthyosis (show LBR Proteins) in Scandinavia, followed by ALOXE3 (show ALOXE3 Proteins) mutations, and TGM1 (show TGM1 Proteins) mutations

  8. 12-R-LOX (show LOX Proteins) and COX-2 play critical roles in the regulation of growth in epidermoid carcinoma

  9. Lipoxygenase-3 (ALOXE3 (show ALOXE3 Proteins)) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.

  10. 12R-LOX hydrolase functions in the normal process of skin differentiation, and that the loss of function mutations are the basis of the LOX (show LOX Proteins)-dependent form of Non-bullous congenital ichthyosiform erythroderma.

Mouse (Murine) Arachidonate 12-Lipoxygenase, 12R Type (ALOX12B) interaction partners

  1. Loss-of-function mutations in the LOX (show LOX Proteins) genes ALOX12B and ALOXE3 (show ALOXE3 Proteins) have been found to represent the second most common cause of autosomal recessive congenital ichthyosis (show LBR Proteins). [review]

  2. The 12R-LOX-eLOX-3 (show ALOXE3 Proteins) pathway plays a key role in the process of epidermal barrier acquisition by affecting lipid metabolism, as well as protein processing.

  3. Alox12b-deficient mouse skin transplants have an ichthyosiform phenotype

ALOX12B Protein Profile

Protein Summary

This gene encodes an enzyme involved in the converstion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma.

Gene names and symbols associated with ALOX12B

  • arachidonate 12-lipoxygenase, 12R type (ALOX12B)
  • arachidonate 12-lipoxygenase, 12R type (alox12b)
  • arachidonate 12-lipoxygenase, 12R type (Alox12b)
  • 12R-LOX protein
  • ALOX12B protein
  • Aloxe2 protein
  • ARCI2 protein
  • e-LOX2 protein
  • MGC85124 protein
  • MGC107915 protein

Protein level used designations for ALOX12B

arachidonate 12-lipoxygenase, 12R type , arachidonate 12-lipoxygenase, 12R-type , arachidonate 12-lipoxygenase, 12R type-like , arachidonate 12-lipoxygenase, 12R-type-like , 12R-lipoxygenase , epidermis-type lipoxygenase 12 , 12R-LOX , e-LOX 2 , epidermis-type lipoxygenase 2

GENE ID SPECIES
455103 Pan troglodytes
489486 Canis lupus familiaris
504803 Bos taurus
548458 Xenopus (Silurana) tropicalis
721936 Macaca mulatta
734312 Xenopus laevis
100062323 Equus caballus
100390364 Callithrix jacchus
100474976 Ailuropoda melanoleuca
100526246 Sus scrofa
242 Homo sapiens
11686 Mus musculus
287425 Rattus norvegicus
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