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Arachidonate 15-Lipoxygenase B Proteins (ALOX15B)

ALOX15B encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. Additionally we are shipping Arachidonate 15-Lipoxygenase B Antibodies (65) and Arachidonate 15-Lipoxygenase B Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALOX15B 247 O15296
ALOX15B 266604 Q8K4F2
Mouse ALOX15B ALOX15B 11688 O35936
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Top Arachidonate 15-Lipoxygenase B Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$753.50
Details
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,967.33
Details

ALOX15B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Rat (Rattus)

More Proteins for Arachidonate 15-Lipoxygenase B (ALOX15B) Interaction Partners

Human Arachidonate 15-Lipoxygenase B (ALOX15B) interaction partners

  1. The ALOX15B gene may be associated with coronary artery disease.

  2. ALOX15 (show ALOX15 Proteins) rs11568070 polymorphisms did not discriminate for the disease or its severity.

  3. 15-LOX2 expression inhibits Myc (show MYC Proteins)-induced prostate cancer development, such that in the 3-month- and 6-month-old double transgenic mice, there is a significant reduction in prostate intraneoplasia.

  4. activated ALOX15B in macrophages may play a role in the induction of atherothrombotic events by increasing platelet aggregation and thrombin (show F2 Proteins) generation

  5. Positive feedback-loop of TERT (show TERT Proteins) and 15-lipoxygenase-2 promotes pulmonary hypertension.

  6. Presented is the crystal structure of 15-LOX-2 in complex with an inhibitor that appears to bind as a substrate mimic. 15-LOX-2 contains a long loop, composed of hydrophobic amino acids, which projects from the amino-terminal membrane-binding domain.

  7. ALOX15B is the mainly expressed 12/15-lipoxygenase in human macrophages and that its expression is induced by IL-4 (show IL4 Proteins), LPS (show IRF6 Proteins) and hypoxia.

  8. Data indicate that expressions of 15-LO-1 and 15-LO-2 in placentas and umbilical artery (HUA) rings in preeclampsia (PE) increased more than that in normal groups.

  9. Tumor-associated macrophages isolated from RCC (show XRCC1 Proteins) tumors had a high 15-LOX2 expression and secreted substantial amounts of 15(S)-hydroxyeicosatetraenoic acid.

  10. In summary, we observed associations between high ALOX15B expression in carotid lesions and a history of cerebrovascular symptoms.

Mouse (Murine) Arachidonate 15-Lipoxygenase B (ALOX15B) interaction partners

  1. Knockdown of mouse Alox15b in vivo decreased plaque lipid content and markers of inflammation.

  2. 15-LOX2 expression in mouse prostate leads to hyperplasia and also induces cell senescence.

  3. 8S-LOX plays a role as a prodifferentiating, antitumorigenic, and tumor suppressing gene in mouse skin carcinogenesis.

  4. Purified recombinant 8S-lipoxygenase can function as a potential 15-LOX (show ALOX15 Proteins) by converting arachidonic acid exclusively to 8S-HPETE and then to (8S,15S)-dihydroperoxy-5Z,9E,11Z,13E-eicosatetraenoic acid (8S,15S-diHPETE).

  5. Expression of 8S-LOX and 15S-LOX-2 (show ALOX5 Proteins) suppresses CRD-BP/IMP-1 (show IGF2BP1 Proteins) expression, resulting in inhibition of human prostate carcinoma PC-3 (show PCSK1 Proteins) cell proliferation.

Arachidonate 15-Lipoxygenase B (ALOX15B) Protein Profile

Protein Summary

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with ALOX15B

  • arachidonate 15-lipoxygenase, type B (ALOX15B)
  • arachidonate 15-lipoxygenase, type B (Alox15b)
  • arachidonate 8-lipoxygenase (Alox8)
  • 8-LOX protein
  • 8S-LOX protein
  • 15-LOX-2 protein
  • 15-LOX-B protein
  • Alox15b protein

Protein level used designations for ALOX15B

arachidonate 15-lipoxygenase, type B , arachidonate 15-lipoxygenase, second type , 15-LOX-B , 15S-lipoxygenase , arachidonate 15-lipoxygenase 2 , arachidonate 15-lipoxygenase B , arachidonate 15-lipoxygenase type II , arachidonate omega(6) lipoxygenase , 15-LOX-2 , 15-lipoxygenase 2 , 8S-lipoxygenase

GENE ID SPECIES
716764 Macaca mulatta
100073039 Equus caballus
455104 Pan troglodytes
247 Homo sapiens
489485 Canis lupus familiaris
286820 Bos taurus
266604 Rattus norvegicus
100525835 Sus scrofa
11688 Mus musculus
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