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ALOX15B encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. Additionally we are shipping Arachidonate 15-Lipoxygenase B Antibodies (70) and Arachidonate 15-Lipoxygenase B Kits (10) and many more products for this protein.
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Ca(2 (show CA2 Proteins)+) binding induces major structural changes in the 15-lipoxygenase-2 PLAT (show PLAT Proteins) domain.
15-LOX-2 is distributed at the plasma membrane when cells are stimulated by the addition Ca(2 (show CA2 Proteins)+) ionophore and that cellular localization is dependent upon the presence of a putative membrane insertion loop.
these results demonstrate the strict regiospecificity of h15-LOX-2 (show ALOX5 Proteins) that circumscribes its role in transcellular synthesis.
This study combined molecular dynamics simulations, QM/MM calculations, and umbrella sampling free energy simulations to study the hydrogen atom abstraction from arachidonic acid catalyzed by the human enzyme 15-lipoxygenase-2.
The ALOX15B gene may be associated with coronary artery disease.
ALOX15 (show ALOX15 Proteins) rs11568070 polymorphisms did not discriminate for the disease or its severity.
15-LOX2 expression inhibits Myc (show MYC Proteins)-induced prostate cancer development, such that in the 3-month- and 6-month-old double transgenic mice, there is a significant reduction in prostate intraneoplasia.
activated ALOX15B in macrophages may play a role in the induction of atherothrombotic events by increasing platelet aggregation and thrombin (show F2 Proteins) generation
Positive feedback-loop of TERT (show TERT Proteins) and 15-lipoxygenase-2 promotes pulmonary hypertension.
Presented is the crystal structure of 15-LOX-2 in complex with an inhibitor that appears to bind as a substrate mimic. 15-LOX-2 contains a long loop, composed of hydrophobic amino acids, which projects from the amino-terminal membrane-binding domain.
Knockdown of mouse Alox15b in vivo decreased plaque lipid content and markers of inflammation.
15-LOX2 expression in mouse prostate leads to hyperplasia and also induces cell senescence.
8S-LOX plays a role as a prodifferentiating, antitumorigenic, and tumor suppressing gene in mouse skin carcinogenesis.
Purified recombinant 8S-lipoxygenase can function as a potential 15-LOX (show ALOX15 Proteins) by converting arachidonic acid exclusively to 8S-HPETE and then to (8S,15S)-dihydroperoxy-5Z,9E,11Z,13E-eicosatetraenoic acid (8S,15S-diHPETE).
Expression of 8S-LOX and 15S-LOX-2 (show ALOX5 Proteins) suppresses CRD-BP/IMP-1 (show IGF2BP1 Proteins) expression, resulting in inhibition of human prostate carcinoma PC-3 (show PCSK1 Proteins) cell proliferation.
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.
arachidonate 15-lipoxygenase, type B
, arachidonate 15-lipoxygenase, second type
, arachidonate 15-lipoxygenase 2
, arachidonate 15-lipoxygenase B
, arachidonate 15-lipoxygenase type II
, arachidonate omega(6) lipoxygenase
, 15-lipoxygenase 2