You are viewing an incomplete version of our website. Please click to reload the website as full version.

Arachidonate 5-Lipoxygenase Proteins (ALOX5)

ALOX5 encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. Additionally we are shipping ALOX5 Antibodies (170) and ALOX5 Kits (70) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALOX5 240 P09917
ALOX5 25290 P12527
ALOX5 11689 P48999
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top ALOX5 Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$693.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,956.33
Details
HOST_Escherichia coli (E. coli) Mouse His tag   100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$704.00
Details
HOST_Baculovirus Human Un-conjugated   500 units Log in to see 7 to 9 Days
$595.36
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$920.54
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ALOX5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Rat (Rattus) ,

Mouse (Murine)

More Proteins for Arachidonate 5-Lipoxygenase (ALOX5) Interaction Partners

Human Arachidonate 5-Lipoxygenase (ALOX5) interaction partners

  1. our data suggest that the inhibition of both COX-2/5-LOX may be an effective therapeutic approach for colon cancer management, particularly for those patients with high expression of COX-2/5-LOX

  2. we identified differences in the frequency distribution in the Tibetan population located in the ALOX5 , VKORC1 (show VKORC1 Proteins) and PTGS2 (show PTGS2 Proteins) genes

  3. AF4 and AF4-MLL (show MLL Proteins) mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D3.

  4. the Alox-5 gene (show GPD1 Proteins) might play a role in the differentiation of multiple drug resistant and non-resistant erythroleukemic cell lines

  5. These results suggest that COX-2 and 5-LO play roles in tumorigenesis and the progression of primary glioblastoma and that the co-expression pattern of COX-2/5-LO may be used as an independent prognostic factor in this disease.

  6. Increased PUFA Content and 5-lipoxygenase pathway expression are associated with subcutaneous adipose tissue inflammation in obese women with type 2 diabetes.

  7. The study shows that 5-lipoxygenase (5-LO) in B cells is phosphorylated on Ser523 and demonstrates for the first time a chemical difference between 5-LO in myeloid cells and B cells.

  8. Study identified a novel splice variant of 5-LO consisting of 139 amino acids due to premature stop. It was found to be expressed in HepG2 cells only, raising the possibility for putative role in liver cancer development.

  9. GSAP (show PION Proteins) cleavage via caspase-3 (show CASP3 Proteins) is regulated and depend upon the availability of 5-Lipoxygenase in Alzheimer's disease.

  10. investigated potential mechanisms by which 5-LO13 interferes with 5-LO product biosynthesis in transfected HEK293 cells

Mouse (Murine) Arachidonate 5-Lipoxygenase (ALOX5) interaction partners

  1. Results establish a key role of 5-Lipoxygenase in the development of the tau pathology phenotype and demonstrate it to be a novel viable therapeutic target for the pharmacologic treatment of human tauopathy.

  2. GSAP (show PION Proteins) cleavage via caspase-3 (show CASP3 Proteins) is regulated and depend upon the availability of 5-Lipoxygenase in Alzheimer's disease.

  3. SHH (show SHH Proteins)-responsive 5-lipoxygenase, 15-lipoxygenase and COX-2 modulate Dectin-1 (show CLEC7A Proteins)-induced inflammatory cytokines.

  4. involvement of lipoxygenase pathways in TNF-alpha (show TNF Proteins)-induced production of cytokines and chemokines

  5. explored the relationship between 5-LO and central and peripheral eosinophilia in an asthma model using PAS (show PASK Proteins) or BALB/c mice and 5-LO-deficient mutants

  6. ALOX5 deficiency prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease.

  7. 5-LO activation coordinates the inflammatory immune response involved in the control of visceral leishmaniasis.

  8. 5-LO(-/-) mice subjected to kidney insult presented lower macrophage infiltration and higher levels of IL-10 (show IL10 Proteins) than wild-type mice.

  9. Alox5 affects the osteogenic and adipogenic abilities of iPSCs in vivo and the effect of Cox2 inhibition in this system.

  10. Data show that resolvin D1 decrease nuclear 5-lipoxygenase (5-LOX) and the leukotrienes LTB4:LXA4 ratio by macrophages lacking calcium-sensitive kinase calcium-calmodulin-dependent protein kinase II (CaMKII).

ALOX5 Protein Profile

Protein Summary

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ALOX5

  • arachidonate 5-lipoxygenase (alox5)
  • arachidonate 5-lipoxygenase (AFUA_4G02770)
  • arachidonate 5-lipoxygenase (AOR_1_1362014)
  • Arachidonate 5-lipoxygenase (lox5)
  • arachidonate 5-lipoxygenase (ALOX5)
  • arachidonate 5-lipoxygenase (Alox5)
  • arachidonate 5-lipoxygenase (LOC100341714)
  • 5-LO protein
  • 5-LOX protein
  • 5LO protein
  • 5LPG protein
  • 5LX protein
  • AI850497 protein
  • F730011J02 protein
  • LOG5 protein
  • lox5 protein
  • LOX5A protein
  • si:dkey-194n13.2 protein

Protein level used designations for ALOX5

LOX2 , arachidonate 5-lipoxygenase , Arachidonate 5-lipoxygenase , LOX-5 , arachidonic 5-lipoxygenase alpha-10 isoform , arachidonic 5-lipoxygenase delta-10-13 isoform , arachidonic 5-lipoxygenase delta-13 isoform , arachidonic 5-lipoxygenase delta-p10 isoform , arachidonic acid 5-lipoxygenase , leukotriene A4 synthase , 5 - Lipoxygenase , 5-LO , 5-lipoxygenase

GENE ID SPECIES
567204 Danio rerio
3503886 Aspergillus fumigatus Af293
5994193 Aspergillus oryzae RIB40
100194803 Salmo salar
240 Homo sapiens
25290 Rattus norvegicus
477753 Canis lupus familiaris
11689 Mus musculus
100341714 Oryctolagus cuniculus
100718093 Cavia porcellus
100156205 Sus scrofa
404074 Bos taurus
423769 Gallus gallus
101117390 Ovis aries
101839970 Mesocricetus auratus
Selected quality suppliers for ALOX5 Proteins (ALOX5)
Did you look for something else?