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Arylsulfatase A Proteins (ARSA)

The protein encoded by ARSA hydrolyzes cerebroside sulfate to cerebroside and sulfate. Additionally we are shipping Arylsulfatase A Antibodies (112) and Arylsulfatase A Kits (38) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ARSA 11883 P50428
ARSA 410 P15289
Rat ARSA ARSA 315222  
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Top Arylsulfatase A Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 50 μg Log in to see 2 to 3 Days
$286.00
Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Mouse His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK-293 Human His tag   0.05 mg Log in to see 2 to 3 Days
$515.63
Details
HOST_HEK293 Human His tag   50 μg Log in to see 5 Days
$423.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$382.86
Details
HOST_Human Human Un-conjugated   10 μg Log in to see 11 to 14 Days
$460.85
Details

ARSA Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , , , , , ,
,

Top referenced Arylsulfatase A Proteins

  1. Human Arylsulfatase A Protein expressed in Human Cells - ABIN2002869 : Schmidt, Selmer, Ingendoh, von Figura: A novel amino acid modification in sulfatases that is defective in multiple sulfatase deficiency. in Cell 1995 (PubMed)
    Show all 4 references for ABIN2002869

  2. Mouse (Murine) Arylsulfatase A Protein expressed in Human Cells - ABIN2007159 : Lukatela, Krauss, Theis, Selmer, Gieselmann, von Figura, Saenger: Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis. in Biochemistry 1998 (PubMed)
    Show all 4 references for ABIN2007159

  3. Human Arylsulfatase A Protein expressed in HEK-293 Cells - ABIN2180601 : Fujii, Kobayashi, Honke, Gasa, Ishikawa, Shimizu, Makita: Proteolytic processing of human lysosomal arylsulfatase A. in Biochimica et biophysica acta 1992 (PubMed)
    Show all 3 references for ABIN2180601

More Proteins for Arylsulfatase A (ARSA) Interaction Partners

Mouse (Murine) Arylsulfatase A (ARSA) interaction partners

  1. Multipotential Neural precursors deficient in arylsulfatase A show a higher ratio of long versus short fatty acid sulfatides, reduction in PDGFRa (show PDGFRA Proteins), decreased AKT (show AKT1 Proteins) phosphorylation, and increased exosomal shedding of PDGFRa (show PDGFRA Proteins).

  2. Sperm arylsulfatase A binds to mZP2 and mZP3 glycoproteins in a nonenzymatic manner.

  3. Sulfogalactosylglycerolipid was a physiological substrate of Sertoli lysosomal arylsulfatase A

  4. study provides the first proof of cognitive deficit and impaired synaptic plasticity in an MLD (show MBP Proteins) mouse model.

  5. ArsA plays a role as a novel component of the extracellular matrix which could be very useful for clarifying the mechanisms underlying some of the syndromes caused by functional deficiency of the Ars (show SLURP1 Proteins) genes.

  6. Data demonstrate a delay in myelin formation in ASA-deficient mice at 2 weeks of age, as a consequence of inability to degrade sulfatide.

  7. Since high cholesterol levels are important for myelination, and various cellular processes, like vesicular trafficking and signal transduction, reduced cholesterol levels might be an important factor in the molecular pathology of MLD (show MBP Proteins).

  8. ASA-deficient [ASA(-/-)] mice overexpressing the sulfatide synthesizing enzymes causes hyperexcitability and axonal degeneration in a mouse model of metachromatic leukodystrophy

  9. The increasing sulfatide storage in ASA(-/-) mice leads to neurological symptoms and morphological alterations that are reminiscent of human MLD (show MBP Proteins).

  10. Safety of Arsa overexpression for gene therapy of metachromatic leukodystrophy was evaluated.

Human Arylsulfatase A (ARSA) interaction partners

  1. Data indicate a significant correlation between the mutation of c.622delC(p.His208Metfs*46) in the arylsulfatase A (ARSA) gene and the phenotype OF metachromatic leukodystrophy.

  2. Sixteen novel mutations that cause metachromatic leukodystrophy have been identified in the arylsulfatase A gene.

  3. Studied brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor (show INSR Proteins).

  4. HSPA2 (show HSPA2 Proteins) regulates the expression of sperm surface receptors involved in human sperm-oocyte recognition, such as arylsulfatase A and SPAM1 (show SPAM1 Proteins).

  5. The interaction between SPAM1 (show SPAM1 Proteins), ARSA and HSPA2 (show HSPA2 Proteins) in a multimeric complex mediating sperm-egg interaction.

  6. This is the first report that human adipocytes express functional DAR (show ATP2A2 Proteins) and ARSA, suggesting a regulatory role for peripheral DA in adipose functions.

  7. The purpose was to estimate the birth prevalence of Metachromatic leukodystrophy in Poland by determining population frequency of the common pathogenic ARSA gene mutations and to compare this estimate with epidemiological data.

  8. The presence of two most common mutations associated with Arylsulfatase A pseudodeficiency was analyzed in 56 patients with diagnosis of relapsing-remitting multiple sclerosis, by polymerase chain reaction restriction fragment length polymorphism method.

  9. cationization of ASA and an increase of the mannose 6-phosphate content of the enzyme may promote blood-to-brain transfer of ASA, thus leading to an improved therapeutic efficacy of enzyme replacement therapy behind the BBB.

  10. ARSA mutations in the Indian population were characterized. 4 new variant & 5 pseudodeficiency alleles were found. Protein modeling showed loss of interactions leading to conformation change.

Pig (Porcine) Arylsulfatase A (ARSA) interaction partners

Arylsulfatase A (ARSA) Protein Profile

Protein Summary

The protein encoded by this gene hydrolyzes cerebroside sulfate to cerebroside and sulfate. Defects in this gene lead to metachromatic leucodystrophy (MLD), a progressive demyelination disease which results in a variety of neurological symptoms and ultimately death. Alternatively spliced transcript variants have been described for this gene.

Gene names and symbols associated with Arylsulfatase A Proteins (ARSA)

  • arylsulfatase A (ARSA)
  • arylsulfatase A (arsa)
  • arylsulfatase A (arsA)
  • arylsulfatase A (RB6599)
  • Arylsulfatase A (arsa)
  • arylsulfatase A (Arsa)
  • arylsulfatase A (AS-A)
  • arylsulfatase A, gene 1 (arsa.1)
  • arsa protein
  • As-2 protein
  • AS-A protein
  • As2 protein
  • ASA protein
  • AW212749 protein
  • mld protein
  • TISP73 protein
  • zgc:101575 protein

Protein level used designations for Arylsulfatase A Proteins (ARSA)

arylsulfatase A , Arylsulfatase A , cerebroside-sulfatase , ASA

GENE ID SPECIES
458946 Pan troglodytes
541416 Danio rerio
716500 Macaca mulatta
1791590 Rhodopirellula baltica SH 1
1791953 Rhodopirellula baltica SH 1
1795188 Rhodopirellula baltica SH 1
1796341 Rhodopirellula baltica SH 1
1796692 Rhodopirellula baltica SH 1
1797062 Rhodopirellula baltica SH 1
100012344 Monodelphis domestica
100195737 Salmo salar
11883 Mus musculus
410 Homo sapiens
315222 Rattus norvegicus
474457 Canis lupus familiaris
396973 Sus scrofa
505514 Bos taurus
426863 Gallus gallus
100351118 Oryctolagus cuniculus
447252 Xenopus laevis
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