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Aspartoacylase Proteins (ASPA)

ASPA encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. Additionally we are shipping ASPA Antibodies (73) and ASPA Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ASPA 443 P45381
ASPA 11484 Q8R3P0
ASPA 79251 Q9R1T5
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Top ASPA Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,834.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,836.17
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,836.17
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,836.17
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,836.17
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,843.50
Details

ASPA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced ASPA Proteins

  1. Human ASPA Protein expressed in Escherichia coli (E. coli) - ABIN668026 : Le Coq, An, Lebrilla, Viola: Characterization of human aspartoacylase: the brain enzyme responsible for Canavan disease. in Biochemistry 2006 (PubMed)
    Show all 2 references for ABIN668026

More Proteins for Aspartoacylase (ASPA) Interaction Partners

Human Aspartoacylase (ASPA) interaction partners

  1. report of 2 Egyptian sibling patients suspected of Canavan disease (CD); study revealed homozygosity for substitution T530C (Ile177Thr) in exon 4 of the ASPA gene in both sibs; substitution T530C (Ile177Thr) results in a novel missense mutation causing a CD phenotype with severe clinical characteristics

  2. Four ASPA missense mutations associated with Canavan disease are structurally characterized.

  3. Definitive evidence is presented to show that the recombinantly-expressed human aspartoacylase is not a glycoprotein.

  4. This is the first case report of ASPA mutation studies in Canavan disease from Indian subcontinent.

  5. a novel mutation Y88X within the aspartoacylase gene in a consanguineous family with an affected child diagnosed as Canavan disease.

  6. Human aspartoacylase gene expression was high not only in brain and kidney, but also in lung and liver.

  7. Gene ASPA (NM_000049) was undertaken to sequence for mutation analysis.

  8. We report on an Italian female patient with Canavan disease due to a missense mutation of the aspartoacylase gene and a 17p13.3 chromosomal microdeletion

  9. the ASPA gene was analysed in 22 unrelated non-Jewish patients with Canavan disease, and 24 different mutations were found

  10. Mild-onset presentation of Canavan's disease associated with novel G212A point mutation in aspartoacylase gene

Mouse (Murine) Aspartoacylase (ASPA) interaction partners

  1. Gata6 (show GATA6 Proteins) regulates differentiation, metabolism, and survival of resident peritoneal macrophages through aspartoacylase.

  2. aspartoacylase is proposed here to support lipid synthesis and energy metabolism via the provision of substrate for both cellular processes during early postnatal development

  3. Intracellular vacuolisation in astrocytes coincides with axonal swellings in cerebellum and brain stem of aspa(lacZ/lacZ (show GLB1 Proteins)) mutants indicating that astroglia may act as an osmolyte buffer in the aspa-deficient CNS

  4. Aspa defects were associated with increased levels of acetylated histone H3 (show HIST3H3 Proteins), decreased chromatin compaction and increased GFAP (show GFAP Proteins) protein, a marker for astrogliosis. Early in postnatal development ASPA defic affects oligodendrocyte maturation and myelination

  5. Death of OLs, neurons, and astrocytes was identified in every region of the aspartoacylase KO brain. These findings support involvement of ASPA in CNS development and function.

  6. ASPA gene defect in the mouse leads to spinal cord pathology; these changes may be involved in the cause of the physiological/behavioral abnormalities seen in the knockout mouse.

  7. normal hydrolysis of N-acetylaspartic acid is affected by aspartoacylase activity seen in the type 2 diabetes model mouse

  8. we now present immunoblot, proteomic, and biochemical evidence that the membrane-bound form of ASPA is intrinsic to purified myelin membranes.

  9. Nur7( Q193X) is a nonsense mutation in the mouse aspartoacylase gene that causes spongy degeneration of the CNS.

ASPA Protein Profile

Protein Summary

This gene encodes an enzyme that catalyzes the conversion of N-acetyl_L-aspartic acid (NAA) to aspartate and acetate. NAA is abundant in the brain where hydrolysis by aspartoacylase is thought to help maintain white matter. This protein is an NAA scavenger in other tissues. Mutations in this gene cause Canavan disease. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with Aspartoacylase Proteins (ASPA)

  • aspartoacylase (ASPA)
  • aspartoacylase (aspa)
  • Aspartoacylase (Fbal_2465)
  • aspartoacylase (Aspa)
  • Acy-2 protein
  • Acy2 protein
  • ASP protein
  • nur7 protein
  • zgc:171507 protein

Protein level used designations for Aspartoacylase Proteins (ASPA)

aspartoacylase (Canavan disease) , Aminoacylase-2 , aspartoacylase (aminoacylase 2, Canavan disease) , Aspartoacylase , ACY-2 , aminoacylase 2 , aminoacylase-2 , aspartoacylase (aminoacylase) 2

GENE ID SPECIES
454430 Pan troglodytes
706170 Macaca mulatta
733935 Xenopus (Silurana) tropicalis
9771274 Ferrimonas balearica DSM 9799
509432 Bos taurus
100142661 Sus scrofa
443 Homo sapiens
100173374 Pongo abelii
11484 Mus musculus
79251 Rattus norvegicus
557232 Danio rerio
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